Protein Alignment Cyp6a23 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 142/536 - (26%)
• Similarity: 241/536 - (44%)
• Gaps: 92/536 - (17%)

  Fly     8 IALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMK----DWPKKRHIAMIFRDYYTKYKRSVY 68
            :.||.::.|:: ||:......|..|....|...|:.|    |..:|      ..:...||.|: :
Human    24 LGLLQAIKLYL-RRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEK------LEEIIEKYPRA-F 80

  Fly    69 PF--AGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDP-LSATLFSIEGQKWRHLR 130
            ||  ..|..||    .|.|.:..|.:|    :..:.:..:..:...| |...|.:::|.||...|
Human    81 PFWIGPFQAFF----CIYDPDYAKTLL----SRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHR 137

  Fly   131 HKLTPTFTSGKMKNMFPII---VKVG-EEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAF 191
            ..|||.|....:|....::   ||:. ::.|||.|.:.|:     :|:.:.:...:.|:|..|||
Human   138 RLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTS-----VEVYEHINSMSLDIIMKCAF 197

  Fly   192 G--LNC--NSLQNPNAEFVTIGKRAIIERRYGGLL--DFLI------FGFPKLSRRLRLKLNVQD 244
            .  .||  ||..:|.|:.:....:.|..|.|..|.  |.:.      :.|.||||
Human   198 SKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSR---------- 252

  Fly   245 VEDFYTSIVRNTIDYRLRT-----------NEKRHDFMDSLIEMYEKEQAGNTEDGLSFNEI--L 296
            |.:.||..:   |..|.::           ..|..||:|.::       :...|.|.||::|  .
Human   253 VLNQYTDTI---IQERKKSLQAGVKQDNTPKRKYQDFLDIVL-------SAKDESGSSFSDIDVH 307

  Fly   297 AQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVV 361
            ::...|.:||.:|.:.::.:.||.|||:.:.|::.|.|:..:|. ..:..|::.:.||.|....:
Human   308 SEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILG-DGSSITWDQLGEMSYTTMCI 371

  Fly   362 METLRKYPVLAHLTRMTQTDFSPEDPKYF-----IAKGTTVVIPALGIHYDPEIYPEPEKFKPER 421
            .||.|..|.:..::|    |.|  .|..|     :..|.|||:...|:|::|.::..|:.|.|.|
Human   372 KETCRLIPAVPSISR----DLS--KPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLR 430

  Fly   422 FTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSIL 486
            |:.|....|....:|||..|.|||||..|.:::..|.:|.::  ..|.|:.:...|:.| ....:
Human   431 FSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALIL--LHFRVTPDPTRPLTF-PNHFI 492

  Fly   487 LSAENGIHLKVEKLSK 502
            |..:||::|.::|||:
Human   493 LKPKNGMYLHLKKLSE 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	123/462 (27%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	127/485 (26%)
		heme binding region	447..460		7/12 (58%)