Protein Alignment Cyp6a23 and Cyp3a18

DIOPT Version :10

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_665725.2
• Gene: Cyp3a18 / 252931
• RGDID: 628709
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 520
• Identity: 168/520 - (32%)
• Similarity: 265/520 - (50%)
• Gaps: 65/520 - (12%)

  Fly     6 TLIALLVSLLLF--MARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFR----------D 58
            |.:.|..||:||  .....||.:::.|||...|.|::|.            ||.          |
  Rat    11 TWVLLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGT------------IFNYGDGMWKFDDD 63

  Fly    59 YYTKYKRSVYPFAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENRGIFYNEIDDPLSATLFSI- 121
            .|.||.:    ..|||........|.|.|::|.||:|: ::.|.||..|     .|:.....:|
  Rat    64 CYKKYGK----IWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCF-----GPMGFMKKAIT 119

  Fly   122 --EGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTAD 184
              |.::|:.||..|:|||||||:|.|||::.:.|:.:.|  :.:....:|:.:.:.|:...|:.|
  Rat   120 MSEDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLK--NLRREEAKGEPINMKDIFGAYSMD 182

  Fly   185 VIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFG--------FPKLS---RRLRL 238
            ||...:||:|.:||.||...||...|:         :|.|.||.        ||.|:   ..|..
  Rat   183 VITGTSFGVNVDSLNNPQDPFVQKAKK---------ILKFQIFDPFLLSVVLFPFLTPIYEMLNF 238

  Fly   239 KLNVQDVEDFYTSIVRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIF 302
            .:..:...:|:...|:.....||.:|:| |.||:..::.. :..:...::..||..|:.|||.||
  Rat   239 SIFPRQSMNFFKKFVKTMKKNRLDSNQKSRVDFLQLMMNT-QNSKGQESQKALSDLEMAAQAIIF 302

  Fly   303 FVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRK 367
            ...|::.:||::.|.:||||...::|.:|:.||:..| .:....||:.:.||:||:.||.|:||.
  Rat   303 IFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRAL-PNKAPVTYDALMEMEYLDMVVNESLRL 366

  Fly   368 YPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPS 432
            ||:...|.|:::.|.  |....||.|||.|.||...:|.:||.:.|||:|.||||:.|...:...
  Rat   367 YPIATRLDRVSKKDV--EINGVFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDP 429

  Fly   433 CTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKV 497
            ..:||||.|||||||:||.|:...:.:..:::.:......:||||:| :.:..:...|..|.||:
  Rat   430 YVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLK-ISRQPIFQPEGPIILKL 493

  Fly   498  497
              Rat   494  493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	145/441 (33%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	148/449 (33%)