Protein Alignment Cyp6a23 and Cyp3a18

DIOPT Version :9

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_665725.2
• Gene: Cyp3a18 / 252931
• RGDID: 628709
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 520
• Identity: 168/520 - (32%)
• Similarity: 265/520 - (50%)
• Gaps: 65/520 - (12%)

  Fly     6 TLIALLVSLLLF--MARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFR----------D 58
            |.:.|..||:||  .....||.:::.|||...|.|::|.            ||.          |
  Rat    11 TWVLLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGT------------IFNYGDGMWKFDDD 63

  Fly    59 YYTKYKRSVYPFAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENRGIFYNEIDDPLSATLFSI- 121
            .|.||.:    ..|||........|.|.|::|.||:|: ::.|.||..|     .|:.....:|
  Rat    64 CYKKYGK----IWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCF-----GPMGFMKKAIT 119

  Fly   122 --EGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTAD 184
              |.::|:.||..|:|||||||:|.|||::.:.|:.:.|  :.:....:|:.:.:.|:...|:.|
  Rat   120 MSEDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLK--NLRREEAKGEPINMKDIFGAYSMD 182

  Fly   185 VIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFG--------FPKLS---RRLRL 238
            ||...:||:|.:||.||...||...|:         :|.|.||.        ||.|:   ..|..
  Rat   183 VITGTSFGVNVDSLNNPQDPFVQKAKK---------ILKFQIFDPFLLSVVLFPFLTPIYEMLNF 238

  Fly   239 KLNVQDVEDFYTSIVRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIF 302
            .:..:...:|:...|:.....||.:|:| |.||:..::.. :..:...::..||..|:.|||.||
  Rat   239 SIFPRQSMNFFKKFVKTMKKNRLDSNQKSRVDFLQLMMNT-QNSKGQESQKALSDLEMAAQAIIF 302

  Fly   303 FVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRK 367
            ...|::.:||::.|.:||||...::|.:|:.||:..| .:....||:.:.||:||:.||.|:||.
  Rat   303 IFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRAL-PNKAPVTYDALMEMEYLDMVVNESLRL 366

  Fly   368 YPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPS 432
            ||:...|.|:::.|.  |....||.|||.|.||...:|.:||.:.|||:|.||||:.|...:...
  Rat   367 YPIATRLDRVSKKDV--EINGVFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGSIDP 429

  Fly   433 CTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKV 497
            ..:||||.|||||||:||.|:...:.:..:::.:......:||||:| :.:..:...|..|.||:
  Rat   430 YVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLK-ISRQPIFQPEGPIILKL 493

  Fly   498  497
              Rat   494  493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	155/484 (32%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	148/449 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8924
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.770