DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp6a23 and Tbxas1

DIOPT Version :9

Sequence 1:NP_611000.2 Gene:Cyp6a23 / 36661 FlyBaseID:FBgn0033978 Length:502 Species:Drosophila melanogaster
Sequence 2:NP_035669.3 Gene:Tbxas1 / 21391 MGIID:98497 Length:533 Species:Mus musculus


Alignment Length:538 Identity:157/538 - (29%)
Similarity:256/538 - (47%) Gaps:70/538 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 LTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYK---RS 66
            :||:..|::||.:.:.......::.||.|..|.|..||:          |.||..:.:.:   |.
Mouse    18 VTLLVALLALLKWYSMSAFSRLEKLGIRHPKPSPFVGNL----------MFFRQGFWESQLELRE 72

  Fly    67 VY-PFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENR---GIFYNEIDDPLSATLFSIEGQKWR 127
            .| |..|:|.......||::.:::|:||:::|::|.||   |:....:.|    ::..:..::|.
Mouse    73 RYGPLCGYYLGRRMHVVISEPDMIKQVLVENFSNFSNRMASGLEPKMVAD----SVLLLRDRRWE 133

  Fly   128 HLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFG 192
            .:|..|..:|:..|:..|.|:|.:..|.:  :...|..........|......||.||:.:.|||
Mouse   134 EVRGALMSSFSPEKLDEMTPLISQACELL--VAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFG 196

  Fly   193 LNCNSLQNPNAEFVTIGKRA---IIERRYGGLLDFLIFGFPK----LSRRLRLKLNVQDVEDFYT 250
            ...:|..:|...||...:||   .|.|.    |..||..||.    |:|.|..| |..::..|:.
Mouse   197 TQVDSQNSPEDPFVQHCRRASTFCIPRP----LLVLILSFPSIMVPLARILPNK-NRDELNGFFN 256

  Fly   251 SIVRNTIDYR--LRTNEKRHDFMDSLIE-MYEKEQAG---------------------------N 285
            :::||.|..|  ....|:|.||:..::: .:.....|                           :
Mouse   257 TLIRNVIALRDQQAAEERRRDFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQRCHPTS 321

  Fly   286 TEDGLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEG 350
            |....:.:||:.|||:|.:||.|..:.|:.|..|.||...|.|::|..|::..:.||... .|..
Mouse   322 TSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAP-EYHS 385

  Fly   351 IKE-MKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEP 414
            ::| :.||:.|:.||||.||.....||....|......:  |..||.:.|....:|:|||.:|.|
Mouse   386 LQEGLPYLDMVISETLRMYPPAFRFTREAAQDCEVLGQR--IPAGTVLEIAVGALHHDPEHWPNP 448

  Fly   415 EKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMK 479
            |.|.|||||.||...|...|:||||.|||:|:|:|.||:...:.:..::..::|..|.|||:|::
Mouse   449 ETFDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVPLQ 513

  Fly   480 FVVKSILLSAENGIHLKV 497
            ...|| .|..:||:::|:
Mouse   514 LESKS-ALGPKNGVYIKI 530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp6a23NP_611000.2 p450 36..495 CDD:278495 148/503 (29%)
Tbxas1NP_035669.3 p450 47..528 CDD:365848 148/505 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0158
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H130979
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D264519at33208
OrthoFinder 1 1.000 - - FOG0000037
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100014
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2429
SonicParanoid 1 1.000 - - X40
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.750

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