Protein Alignment Cyp6a23 and CYP4Z1

DIOPT Version :9

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 139/534 - (26%)
• Similarity: 241/534 - (45%)
• Gaps: 82/534 - (15%)

  Fly     5 LTLIALLVSLLLFMA-----RRRHGYWQRRGI---PHDVPHPIYGNMKDWPKKRHIAMIFRDYYT 61
            |.||.|.:|||||..     |||   |..|.:   |....|..||:.:.:|.|..  .::.....
Human    15 LLLILLCMSLLLFQVIRLYQRRR---WMIRALHLFPAPPAHWFYGHKEFYPVKEF--EVYHKLME 74

  Fly    62 KYKRSVYPFAG-FYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSAT-------- 117
            ||..:|..:.| |..||:    :.|.:..| :|:|.              .||.||.
Human    75 KYPCAVPLWVGPFTMFFS----VHDPDYAK-ILLKR--------------QDPKSAVSHKILESW 120

  Fly   118 ----LFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAK--TTTGEGQVLEIVD 176
                |.:::|.||:..|..:.|.|....:|    |.:.:..|..::...|  ....:...||:..
Human   121 VGRGLVTLDGSKWKKHRQIVKPGFNISILK----IFITMMSESVRMMLNKWEEHIAQNSRLELFQ 181

  Fly   177 LVARYTADVIGNCAF----GLNCNSLQNPNAEFV-TIGKRAIIERRYGGLL--DFLIFGFPKLSR 234
            .|:..|.|.|..|||    .:..:|..:...:.| .:.|  |..:|....|  :.|:|.|.. ..
Human   182 HVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSK--ISNQRMNNFLHHNDLVFKFSS-QG 243

  Fly   235 RLRLKLNVQDVEDFYTSIV---RNTIDYRLR---TNEKRHDFMDSLIEMYEKEQAGNTEDGLSFN 293
            ::..|.| |::..|...::   :.::..:|:   |.::|.||:|.|:    ..::.||:|   |:
Human   244 QIFSKFN-QELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILL----SAKSENTKD---FS 300

  Fly   294 EILAQAFI--FFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKY 356
            |...||.:  |..||.:|:|:.:.:.||.||...:.|.:.|.||..:|. ..:..|:|.:.:|.|
Human   301 EADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLG-DGSSITWEHLSQMPY 364

  Fly   357 LEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPER 421
            ....:.|.||.|..:.:::|:.....:..|.:...| |.||.|....:|::|..:.:|:.|.|.|
Human   365 TTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPA-GITVFINIWALHHNPYFWEDPQVFNPLR 428

  Fly   422 FTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSIL 486
            |:.|.........::||..|.|||||..|.:::..|.:|..:  .:|.::.:...|.: .|:.::
Human   429 FSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTL--LRFKLAPDHSRPPQ-PVRQVV 490

  Fly   487 LSAENGIHLKVEKL 500
            |.::||||:..:|:
Human   491 LKSKNGIHVFAKKV 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	122/488 (25%)
CYP4Z1	NP_835235.1	p450	47..500	CDD:278495	124/493 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810