Protein Alignment Cyp6a23 and cyp-13A12

DIOPT Version :10

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_499705.1
• Gene: cyp-13A12 / 184473
• WormBaseID: WBGene00008810
• Length: 518
• Species: Caenorhabditis elegans
• Alignment Length: 543
• Identity: 147/543 - (27%)
• Similarity: 258/543 - (47%)
• Gaps: 112/543 - (20%)

  Fly     3 LLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGN--------------MKDWPKKRHIA 53
            :.|.::..::.:|.|.. ....||:||||.....:||.|:              :|:|.|:
 Worm     4 IFLAILTSIIGVLSFYL-WTWSYWKRRGIAGPSGYPILGSALEMLSSENPPYLQLKEWTKQ---- 63

  Fly    54 MIFRDYYTKYKRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEID-DP---L 114
                  |.|    ||   |.....:|:.||:|.:||:.|.:|.:::|..|.:  |.|. ||   .
 Worm    64 ------YGK----VY---GITEGLSRTLVISDPDLVQEVFVKQYDNFFGRKL--NPIQGDPNKDK 113

  Fly   115 SATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVA 179
            ...|||.:|.:|:.||...:|||::..::.:...:.:...|:  :...:..|..||.::::|...
 Worm   114 RVNLFSSQGHRWKRLRTISSPTFSNNSLRKLKTTVEECAVEL--LRHIEQHTDGGQPIDLLDFYQ 176

  Fly   180 RYTADVIGNCAFG-LNCNSLQNPNAEFVTIGKRAII-ERR------------YGGLLDFLIFGFP 230
            .:|.||||..|.| .:....:||...:|    ||:. |.|            .|.:|..::|..|
 Worm   177 EFTLDVIGRIAMGQTDSQMFKNPLLPYV----RAVFGEPRKGLFLSGSLAPWIGPILRMVMFSLP 237

  Fly   231 KLSRRLRLKLNVQDVEDFYTSIVR---NTIDYRLR---TNEKR-------HDFMDSLIEMYEKE- 281
            .:            |::....::|   |.::.|::   .:||.       .||:|..::....:
 Worm   238 NI------------VKNPAVHVIRHTSNAVEQRVKLRMADEKAGIDPGEPQDFIDLFLDAKSDDV 290

  Fly   282 QAGNTED----------GLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEIN 336
            :..|.||          .|:..||:.|.|:|.:|||:|::.::.::.:.||....:|.:|:.||:
 Worm   291 ELENNEDFTKAGVKVTRQLTTEEIVGQCFVFLIAGFDTTALSLSYSSFLLATHPKVQKKLQEEID 355

  Fly   337 NVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPV--LAH---LTRMTQTDFSPEDPKYFIAKGTT 396
            ...:  :.|.|::.:.::||:|.|:.||||.||:  ||:   ..|.|:..      .|.|.:||.
 Worm   356 RECA--DPEVTFDQLSKLKYMECVIKETLRMYPLGALANSRCCMRATKIG------NYEIDEGTN 412

  Fly   397 VVIPALGIHYDPEIYPE-PEKFKPERFT--DEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVG 458
            ::.....:|.|..|:.| .|:|||||:.  ||....:..  ::|||.|||.|||:|...|:..:.
 Worm   413 ILCDTWTLHSDKSIWGEDAEEFKPERWESGDEHFYQKGG--YIPFGLGPRQCIGMRLAYMEEKLL 475

  Fly   459 LAYLIRGYKFSVSTETQIPMKFV 481
            |::::|.|...|..:||||:|.:
 Worm   476 LSHILRKYTLEVCNKTQIPLKLI 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	129/464 (28%)
cyp-13A12	NP_499705.1	CYP3A-like	63..507	CDD:410678	132/483 (27%)