Protein Alignment Cyp6a23 and Cyp3a62

DIOPT Version :10

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001019403.1
• Gene: Cyp3a62 / 170509
• RGDID: 1595919
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 490
• Identity: 168/490 - (34%)
• Similarity: 258/490 - (52%)
• Gaps: 44/490 - (8%)

  Fly     7 LIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKD-----WPKKRHIAMIFRDYYTKYKRS 66
            |:|.::.||.......||.:::.||....|.|..||:..     |...||....:.|.:
  Rat    14 LLATILVLLYLYGTSTHGNFKKLGISGPKPLPFVGNILAYRHGFWEFDRHCHKKYGDIW------ 72

  Fly    67 VYPFAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENRGIFYNEIDDP---LSATLFSIEGQKWR 127
                 |||........|||.:::|.||:|: ::.|.||..|     .|   |...:...|.::|:
  Rat    73 -----GFYEGRQPILAITDPDIIKTVLVKECYSTFTNRRSF-----GPAGILKKAITLSEDEEWK 127

  Fly   128 HLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFG 192
            .||..|:|||||||:|.|||||.:..:.:.|  :.|....:|..:.:.|:...|:.|||...:||
  Rat   128 RLRTLLSPTFTSGKLKEMFPIINQYADLLVK--NVKHEAEKGNPITMKDIFGAYSMDVITGTSFG 190

  Fly   193 LNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFL--IFGFPKLS---RRLRLKLNVQDVEDFYTSI 252
            :|.:||.||...||...|:.:   ::..|..|.  :..||.|:   ....:.:..:||..|:.:.
  Rat   191 VNVDSLNNPQNPFVQKVKKLL---KFNFLDPFFLSVILFPFLTPVFEAFDITVFPKDVMKFFRTS 252

  Fly   253 VRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTE--DGLSFNEILAQAFIFFVAGFETSSTTM 314
            |....:.|::...| |.||:..:|   ..:.:|:.|  .||:..||:||:..|..||:||:|:.:
  Rat   253 VERMKENRMQEKVKQRLDFLQLMI---NSQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSSAL 314

  Fly   315 GFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQ 379
            .||||.||...|:|.:|:.||:..| .:....||:.:.||:||:.|:.||||.:||...|.|:.:
  Rat   315 SFALYLLATHPDLQKKLQDEIDAAL-PNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCK 378

  Fly   380 TDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRN 444
            .|.  |....||.|||.|::|...:|.||:.:||||:|.||||..:...:.....:||||.||||
  Rat   379 KDV--EINGVFIPKGTVVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPFGNGPRN 441

  Fly   445 CIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMK 479
            |||:||.||...:.|..:::.:.|.:..|||||:|
  Rat   442 CIGMRFALMNMKIALVRVLQNFSFGLCKETQIPLK 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	152/424 (36%)
Cyp3a62	NP_001019403.1	CYP3A	67..492	CDD:410743	153/437 (35%)