Protein Alignment Cyp6a23 and CYP26A1

DIOPT Version :9

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 493
• Identity: 107/493 - (21%)
• Similarity: 186/493 - (37%)
• Gaps: 97/493 - (19%)

  Fly     3 LLLTLIALLVSLLLFMARRRHGYWQRRGI------------PHDVPHPIYGNMKDWPKKRHIAMI 55
            |...|...::.||||:|..:  .|....:            |..:..|.:|..        :.|:
Human     7 LASALCTFVLPLLLFLAAIK--LWDLYCVSGRDRSCALPLPPGTMGFPFFGET--------LQMV 61

  Fly    56 F-RDYYTKYKRSVYPFAGFYFFFTRSAV-ITDLELVKRVLIKDFNHFENRGIFYNEIDDPL---- 114
            . |..:.:.||..|.|......|.|..| :...:.|:|:|:.     |:|.:   .:..|.
Human    62 LQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLG-----EHRLV---SVHWPASVRT 118

  Fly   115 ---SATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIV-KVGEEMEKIFSAKTTTGEGQVL--- 172
               |..|.::.....:..:..:...|:...::...|:|. :||..:|:..|.    ||..:|
Human   119 ILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSC----GERGLLVYP 179

  Fly   173 EIVDLVARYTADVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDF---LIFGFPKLSR 234
            |:..|:.|....::..|                         |.:..|..|.   |:..|.:::|
Human   180 EVKRLMFRIAMRILLGC-------------------------EPQLAGDGDSEQQLVEAFEEMTR 219

  Fly   235 RL-RLKLNVQDVEDFYTSI-VRNTIDYR-----------LRTNEKRHDFMDSLIEMYEKEQAGNT 286
            .| .|.::| .....|..: .||.|..|           ||.:|......|:|..:.  |.:...
Human   220 NLFSLPIDV-PFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLI--EHSWER 281

  Fly   287 EDGLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINN--VLSKHN--NEFT 347
            .:.|....:...:......|.||:::.....:..|.|...:..::|.|:.:  :|.|.|  |:..
Human   282 GERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLD 346

  Fly   348 YEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYP 412
            .|.::::||:..|:.||||..|.:....|:....|  |...|.|.||..|:......|...||:.
Human   347 MEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTF--ELNGYQIPKGWNVIYSICDTHDVAEIFT 409

  Fly   413 EPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRF 450
            ..|:|.|:||...........:::|||.|.|:|:|..|
Human   410 NKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEF 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	98/448 (22%)
CYP26A1	NP_000774.2	p450	14..492	CDD:299894	105/486 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030