DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and CYP19A1

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_000094.2	Gene:	CYP19A1 / 1588	HGNCID:	2594	Length:	503	Species:	Homo sapiens

Alignment Length:	503	Identity:	109/503 - (21%)
Similarity:	200/503 - (39%)	Gaps:	102/503 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLLTLIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFR------DYYT 61
            ||||.:.|||             |...| ...:|.|.| .|...|...|...::.      :||.
Human    29 LLLTGLFLLV-------------WNYEG-TSSIPGPGY-CMGIGPLISHGRFLWMGIGSACNYYN 78

  Fly    62 KYKRSVY-PFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENR---------------GIFYNEI 110
            :    || .|...:.....:.:|:....:..::  ..||:.:|               ||.:|
Human    79 R----VYGEFMRVWISGEETLIISKSSSMFHIM--KHNHYSSRFGSKLGLQCIGMHEKGIIFN-- 135

  Fly   111 DDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKT-------TTGE 168
            ::|          :.|:..|.......:...:..|..:..:         |.||       .|.|
Human   136 NNP----------ELWKTTRPFFMKALSGPGLVRMVTVCAE---------SLKTHLDRLEEVTNE 181

  Fly   169 GQVLEIVDLVARYTADVIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFG--FPK 231
            ...::::.|:.|...|. .|..|      |:.|..|...:.|   |:..:......||..  |.|
Human   182 SGYVDVLTLLRRVMLDT-SNTLF------LRIPLDESAIVVK---IQGYFDAWQALLIKPDIFFK 236

  Fly   232 LS-RRLRLKLNVQDVEDFYTSIVRNTIDYRLRTNEKRHDFMDSLIEMYEKEQAGN-TEDGLSFNE 294
            :| ...:.:.:|:|::|....::... ..|:.|.||..:.||...|:...|:.|: |.:.:  |:
Human   237 ISWLYKKYEKSVKDLKDAIEVLIAEK-RRRISTEEKLEECMDFATELILAEKRGDLTRENV--NQ 298

  Fly   295 ILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQ 359
            .:.:   ..:|..:|.|.::.|.|:.:|...::::.:..||..|:.:  .:...:.|:::|.:|.
Human   299 CILE---MLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE--RDIKIDDIQKLKVMEN 358

  Fly   360 VVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTD 424
            .:.|::|..||:..:.|....|...:.  |.:.|||.::: .:|..:..|.:|:|.:|..|.|..
Human   359 FIYESMRYQPVVDLVMRKALEDDVIDG--YPVKKGTNIIL-NIGRMHRLEFFPKPNEFTLENFAK 420

  Fly   425 EAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVST 472
            ..    |...:.|||.|||.|.|....::.....|..|:|  :|.|.|
Human   421 NV----PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLR--RFHVKT 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	100/470 (21%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	94/445 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010