DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and CYP4B1

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001093242.1	Gene:	CYP4B1 / 1580	HGNCID:	2644	Length:	512	Species:	Homo sapiens

Alignment Length:	402	Identity:	100/402 - (24%)
Similarity:	179/402 - (44%)	Gaps:	40/402 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 LFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAK--TTTGEGQVLEIVDLVAR 180
            |..:||.||...|..|||.|....:|.    .|.|..|..:|...|  ....||:..:|...|..
Human   126 LLVLEGPKWLQHRKLLTPGFHYDVLKP----YVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGH 186

  Fly   181 YTADVIGNCAFGLNCNSLQNPN--------AEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRLR 237
            ...:.:..|.||.....|.:..        ::...:.::.::..:|..  ||:.:..|...|.||
Human   187 MALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSFQYHN--DFIYWLTPHGRRFLR 249

  Fly   238 LKLNVQDVEDFYTSIVR------NTIDYRLRTNEKRH-DFMDSLIEMYEKEQAGNTEDG--LSFN 293
            .   .|...|....::|      .....|.:...:|| ||:|.|:       ....||.  ||..
Human   250 A---CQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILL-------GARDEDDIKLSDA 304

  Fly   294 EILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLE 358
            ::.|:...|...|.:|:::.:.:.||.:||..:.|.:.|.|:..:|. ..:.|.::.:.:|.||.
Human   305 DLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILG-DQDFFQWDDLGKMTYLT 368

  Fly   359 QVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFT 423
            ..:.|:.|.||.:..:.|......:..|.:...| |:.:.:....:|.:..::|:||.|...||:
Human   369 MCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA-GSLISMHIYALHRNSAVWPDPEVFDSLRFS 432

  Fly   424 DEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLS 488
            .|..:.|....::||..|||||||.:|.:.:..|..|..:..::||:. .:::|:|  :..::|.
Human   433 TENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLD-PSRLPIK--MPQLVLR 494

  Fly   489 AENGIHLKVEKL 500
            ::||.||.::.|
Human   495 SKNGFHLHLKPL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	97/395 (25%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	97/395 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910