Protein Alignment Cyp6a23 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 130/538 - (24%)
• Similarity: 237/538 - (44%)
• Gaps: 90/538 - (16%)

  Fly     2 SLLLTLIALLVSLLLFMARRRHGYWQRRGI---PHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKY 63
            |||:.|:.|:.::.|::    |..|..:.:   |....|.::|::::..:.:.:..|.:...|
Human    23 SLLILLLLLIKAVQLYL----HRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVET-- 81

  Fly    64 KRSVYPFAGFYFFFTRSAVIT--DLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQKW 126
                :|.|..::.:.....:.  |.:.:|.:|.:  :..::.| .|..:...:...|..:.||.|
Human    82 ----FPSACPHWLWGGKVRVQLYDPDYMKVILGR--SDPKSHG-SYRFLAPWIGYGLLLLNGQTW 139

  Fly   127 RHLRHKLTPTF-------TSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTAD 184
            ...|..|||.|       ..|.|.:...:::...||:         .|:...||:...|:..|.|
Human   140 FQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEEL---------LGQDSPLEVFQHVSLMTLD 195

  Fly   185 VIGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRLRLKLNVQDVEDFY 249
            .|..|||....:...:.|::...   :||.:      |:.|:|.      |:|...:..|.....
Human   196 TIMKCAFSHQGSIQVDRNSQSYI---QAISD------LNNLVFS------RVRNAFHQNDTIYSL 245

  Fly   250 TSIVRNT--------------IDYRL----------RTNEKRH-DFMDSLIEMYEKEQAGNTEDG 289
            ||..|.|              |..|.          :...||| ||:|.|:       ....|:|
Human   246 TSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILL-------LAKMENG 303

  Fly   290 --LSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIK 352
              ||..::.|:...|...|.:|:::.:.:.||.||.....|::.|.||:::|. .....|:..:.
Human   304 SILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLG-DGASITWNHLD 367

  Fly   353 EMKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKF 417
            :|.|....:.|.||.||.:..:.|...|..:..|.: .:.||..|::...|:|::|:::|.||.|
Human   368 QMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNPEVF 431

  Fly   418 KPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVV 482
            .|.||...  :|:.|..:|||..|.|||||.:|.:.:..|..|..:..::. :...|:||:.  :
Human   432 DPFRFAPG--SAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL-LPDPTRIPIP--I 491

  Fly   483 KSILLSAENGIHLKVEKL 500
            ..::|.::|||||::.:|
Human   492 ARLVLKSKNGIHLRLRRL 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	113/461 (25%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	117/477 (25%)