DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	505	Identity:	172/505 - (34%)
Similarity:	273/505 - (54%)	Gaps:	38/505 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKRSVYPFA 71
            |:|:.:.||.....|.||.::|.|||...|.|:.||:..:  ::.:.....:.|.||.:    ..
Human    14 LLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSY--RQGLWKFDTECYKKYGK----MW 72

  Fly    72 GFYFFFTRSAVITDLELVKRVLIKD-FNHFENR------GIFYNEIDDPLSATLFSIEGQKWRHL 129
            |.|........|||.::::.||:|: ::.|.||      |.        :.:.:...|.::|:.:
Human    73 GTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGF--------MKSAISLAEDEEWKRI 129

  Fly   130 RHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLN 194
            |..|:|||||||:|.|||||.:.|:.:  :.:.:....:|:.:.:.|:...|:.|||...:||:|
Human   130 RSLLSPTFTSGKLKEMFPIIAQYGDVL--VRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVN 192

  Fly   195 CNSLQNPNAEFVTIGKRAIIERRYGGL----LDFLIFGF-PKLSRRLRLKLNVQDVEDFYTSIVR 254
            .:||.||...||...|:.:   ::|.|    |..::|.| ..:...|.:.|..:|..:|.:..|.
Human   193 IDSLNNPQDPFVESTKKFL---KFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVN 254

  Fly   255 NTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMGFAL 318
            .....||...:| |.||:..:|:....::. .:...||..|:.||:.||..||:||:|:.:.|.|
Human   255 RMKKSRLNDKQKHRLDFLQLMIDSQNSKET-ESHKALSDLELAAQSIIFIFAGYETTSSVLSFTL 318

  Fly   319 YELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTDFS 383
            ||||...|:|.:|:.||:.|| .:....||:.:.:|:||:.||.||||.:||...|.|..:.|.
Human   319 YELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDV- 381

  Fly   384 PEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGL 448
             |....||.||:.||||...:|:||:.:.|||:|:||||:.:..:..| ..:.|||.|||||||:
Human   382 -EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDP-YIYTPFGTGPRNCIGM 444

  Fly   449 RFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVE 498
            ||.||...:.|..:::.:.|....|||||:|...:. ||..|..|.|||:
Human   445 RFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG-LLQPEKPIVLKVD 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	158/471 (34%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	160/477 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.720