DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp6a23 and CYP3A4

DIOPT Version :9

Sequence 1:NP_611000.2 Gene:Cyp6a23 / 36661 FlyBaseID:FBgn0033978 Length:502 Species:Drosophila melanogaster
Sequence 2:NP_059488.2 Gene:CYP3A4 / 1576 HGNCID:2637 Length:503 Species:Homo sapiens


Alignment Length:507 Identity:178/507 - (35%)
Similarity:274/507 - (54%) Gaps:41/507 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKRSVYPFA 71
            |:|:.:.||.......||.:::.|||...|.|..||:..:.|  ...|...:.:.||.: |:   
Human    14 LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHK--GFCMFDMECHKKYGK-VW--- 72

  Fly    72 GFYFFFTRSAVITDLELVKRVLIKD-FNHFENRGIFYNEIDDP---LSATLFSIEGQKWRHLRHK 132
            |||........|||.:::|.||:|: ::.|.||..|     .|   :.:.:...|.::|:.||..
Human    73 GFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKSAISIAEDEEWKRLRSL 132

  Fly   133 LTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLNCNS 197
            |:|||||||:|.|.|||.:.|:.:.:....:..||:...|:  |:...|:.|||.:.:||:|.:|
Human   133 LSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLK--DVFGAYSMDVITSTSFGVNIDS 195

  Fly   198 LQNPNAEFVTIGKRAIIERRYGGLLDFL------IFGFPKLSRRLRLKLNV----QDVEDFYTSI 252
            |.||...||...|:.:   |:    |||      |..||.|...|.: ||:    ::|.:|....
Human   196 LNNPQDPFVENTKKLL---RF----DFLDPFFLSITVFPFLIPILEV-LNICVFPREVTNFLRKS 252

  Fly   253 VRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMGF 316
            |:...:.||...:| |.||:..:|:....::. .:...||..|::||:.||..||:||:|:.:.|
Human   253 VKRMKESRLEDTQKHRVDFLQLMIDSQNSKET-ESHKALSDLELVAQSIIFIFAGYETTSSVLSF 316

  Fly   317 ALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQTD 381
            .:||||...|:|.:|:.||:.|| .:....||:.:.:|:||:.||.||||.:|:...|.|:.:.|
Human   317 IMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD 380

  Fly   382 FSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCI 446
            .  |....||.||..|:||:..:|.||:.:.|||||.||||:.:.........:.|||.||||||
Human   381 V--EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCI 443

  Fly   447 GLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVE 498
            |:||.||...:.|..:::.:.|....|||||:|..:.. ||..|..:.||||
Human   444 GMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG-LLQPEKPVVLKVE 494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp6a23NP_611000.2 p450 36..495 CDD:278495 165/473 (35%)
CYP3A4NP_059488.2 p450 39..493 CDD:365848 167/479 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D264519at33208
OrthoFinder 1 1.000 - - FOG0000037
OrthoInspector 1 1.000 - - mtm8447
orthoMCL 1 0.900 - - OOG6_100014
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2429
SonicParanoid 1 1.000 - - X40
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.850

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