Protein Alignment Cyp6a23 and CYP3A7

DIOPT Version :9

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 181/515 - (35%)
• Similarity: 274/515 - (53%)
• Gaps: 57/515 - (11%)

  Fly     7 LIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFR--------DYYTKY 63
            |:|:.:.||.....|.||.:::.|||...|.|..||          |:.||        :.|.||
Human    14 LLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGN----------ALSFRKGYWTFDMECYKKY 68

  Fly    64 KRSVYPFAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENR------GIFYNEIDDPLSATLFSI 121
             |.|:   |.|........|||.:::|.||:|: ::.|.||      |...|.|         ||
Human    69 -RKVW---GIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAI---------SI 120

  Fly   122 -EGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADV 185
             |.::|:.:|..|:|||||||:|.|.|||.:.|:.:.:....:..||:...|:.|  ...|:.||
Human   121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHV--FGAYSMDV 183

  Fly   186 IGNCAFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFL--IFGFPKLSRRLRLKLNV----QD 244
            |.:.:||::.:||.||...||...|:.:   |:..|..|:  |..||.|:..|. .||:    :.
Human   184 ITSTSFGVSIDSLNNPQDPFVENTKKLL---RFNPLDPFVLSIKVFPFLTPILE-ALNITVFPRK 244

  Fly   245 VEDFYTSIVRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFE 308
            |..|.|..|:...:.||:..:| |.||:..:|:. :..:...|...||..|::||:.||..||:|
Human   245 VISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDS-QNSKDSETHKALSDLELMAQSIIFIFAGYE 308

  Fly   309 TSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAH 373
            |:|:.:.|.:||||...|:|.:::.||:.|| .:....||:.:.:::||:.||.||||.:||...
Human   309 TTSSVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMR 372

  Fly   374 LTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPF 438
            |.|:.:.|.  |....||.||..|:||:..:|:||:.:.|||||.||||:.:.........:.||
Human   373 LERVCKKDV--EINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPF 435

  Fly   439 GEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVE 498
            |.|||||||:||.|:...:.|..:::.:.|....|||||:|.....:||: |..|.||.|
Human   436 GSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLT-EKPIVLKAE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	168/481 (35%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	169/486 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820