DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp3a11

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus

Alignment Length:	507	Identity:	175/507 - (34%)
Similarity:	277/507 - (54%)	Gaps:	34/507 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLTLIALLVSLLLF--MARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKRS 66
            |.|.:.|.:||:|.  ...|:|..::::|||...|.|..|.:.::.|  .:.....:.|.||.::
Mouse     9 LETWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYYK--GLWKFDMECYKKYGKT 71

  Fly    67 VYPFAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENR------GIFYNEIDDPLSATLFSIEGQ 124
            ...|.|    .|....:||.|.:|.||:|: |:.|.||      ||        :|..:...:..
Mouse    72 WGLFDG----QTPLLAVTDPETIKNVLVKECFSVFTNRRDFGPVGI--------MSKAISISKDD 124

  Fly   125 KWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNC 189
            :|:..|..|:|||||||:|.|||:|.:.|:.:.|....|..  :|:.:.:.|::..|:.|||.:.
Mouse   125 EWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKAK--KGKPVTMKDVLGAYSMDVITST 187

  Fly   190 AFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLS---RRLRLKLNVQDVEDFYTS 251
            :||:|.:||.||...||...|:.:....:..|| |.:..||.|:   ..|.:.:..:|..:|:..
Mouse   188 SFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLL-FSVVLFPFLTPVYEMLNICMFPKDSIEFFKK 251

  Fly   252 IVRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMG 315
            .|....:.||.:.:| |.||:..::..:...:...:...||..||.||:.||..||:||:|:|:.
Mouse   252 FVDRMKESRLDSKQKHRVDFLQLMMNSHNNSKDKVSHKALSDMEITAQSIIFIFAGYETTSSTLS 316

  Fly   316 FALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQT 380
            |.|:.||...|||.:|:.||:..| .:....||:.:.||:||:.|:.||||.||:...|.|:.:.
Mouse   317 FTLHSLATHPDIQKKLQDEIDEAL-PNKAPPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKK 380

  Fly   381 DFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNC 445
            |.  |....:|.||:||:||:..:|:||:.:.|||:|:||||:.|...:.....:||||.|||||
Mouse   381 DV--ELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNC 443

  Fly   446 IGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKV 497
            :|:||.||...:.|..:::.:.|....|||||:| :.:..||..|..|.|||
Mouse   444 LGMRFALMNMKLALTKIMQNFSFQPCKETQIPLK-LSRQGLLQPEKPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	161/469 (34%)
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	163/475 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750