Protein Alignment Cyp6a23 and CYP4F8

DIOPT Version :9

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 447
• Identity: 123/447 - (27%)
• Similarity: 203/447 - (45%)
• Gaps: 67/447 - (14%)

  Fly    80 SAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKN 144
            |..|||.::|                ||..:...|...|....|.||||.|..|||.|..    |
Human   114 SDAITDKDIV----------------FYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHF----N 158

  Fly   145 MFPIIVKVGEEMEKIFSAK--TTTGEGQV-LEIVDLVARYTADVIGNCAFGLNCNSLQNPNAEFV 206
            :....:|:..:...|..||  ....||.. |::.:.::..|.|.:..|.|..:.|..:.| :|::
Human   159 ILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKP-SEYI 222

  Fly   207 TIGKRAIIE---------RRYGGLLDFLIFGFP---KLSRRLRLKLNVQDVEDFYTSIV---RNT 256
            |    ||:|         .::....|||.|..|   :..|..||      |.||..:::   |.|
Human   223 T----AIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRL------VHDFTDAVIQERRRT 277

  Fly   257 I------DY-RLRTNEKRHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTM 314
            :      |: :.:...|..||:|.|:...:|    |.:: ||..:|.|:|..|...|.:|:::.:
Human   278 LTSQGVDDFLQAKAKSKTLDFIDVLLLSEDK----NGKE-LSDEDIRAEADTFMFGGHDTTASGL 337

  Fly   315 GFALYELALDQDIQDQLRAEINNVL-SKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMT 378
            .:.||.||...:.|::.|.|:..:| .:...|..::.:.::.:|...:.|:||.:|.:....|..
Human   338 SWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGC 402

  Fly   379 QTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPR 443
            ..|....|.: .|.||....|....||::|.::|:||.:.|.||..|....|....::||..|||
Human   403 TQDVVLPDSR-VIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPR 466

  Fly   444 NCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEKL 500
            ||||.:|.:.:..|.||..:  .:|.:..:.:.|.:  ...|:|.||:|:.|:||.|
Human   467 NCIGQKFAMAEMKVVLALTL--LRFRILPDHREPRR--TPEIVLRAEDGLWLRVEPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	119/440 (27%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	114/430 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820