Protein Alignment Cyp6a23 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 125/491 - (25%)
• Similarity: 219/491 - (44%)
• Gaps: 60/491 - (12%)

  Fly     3 LLLTLIALLVSLLL---FMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHI-AMIFRDYYTKY 63
            |||...|:|::..|   |:.|.|..|....|.|.  |..:.|::..:.||..: ..:.:|.:..:
Human     5 LLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPR--PSFLLGHLPCFWKKDEVGGRVLQDVFLDW 67

  Fly    64 KRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDPLSATLFSIEG----- 123
            .:...|......|...|.::|..|.||:.|:.  ..:......|..:.......||. :|
Human    68 AKKYGPVVRVNVFHKTSVIVTSPESVKKFLMS--TKYNKDSKMYRALQTVFGERLFG-QGLVSEC 129

  Fly   124 --QKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTA-DV 185
              ::|...|..:...|:...:.::.....:..|::.:|..||   .:||....:..:..||| |:
Human   130 NYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK---ADGQTPVSMQDMLTYTAMDI 191

  Fly   186 IGNCAFGLNCNSL---QNPNAEFVTIGKRAIIERRYGGLLDFLIFGFPKLSRRLRLKLNVQDVED 247
            :...|||:..:.|   |.|.::.|.:....|...| ..|..||    |...::||   .|::...
Human   192 LAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASR-NTLAKFL----PGKRKQLR---EVRESIR 248

  Fly   248 FYTSIVRNTIDYRLRTNEKRHDFM--DSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETS 310
            |...:.|:.:. |.|...||.:.:  |.|.::.:.|:....::||..|.:     .||:||.|||
Human   249 FLRQVGRDWVQ-RRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFV-----TFFIAGHETS 307

  Fly   311 STTMGFALYELALDQDIQDQLRAEINNVL-SKHNNEFTYEGIKEMKYLEQVVMETLRKYP----- 369
            :..:.|.:.||:...:|..:|:||::.|: ||...:|  |.:..::||.||:.|:||.||
Human   308 ANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDF--EDLGRLQYLSQVLKESLRLYPPAWGT 370

  Fly   370 --VLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPS 432
              :|...|.:.........|..|    :|.|:..:..:::     :|..|.|:||...  |.:|.
Human   371 FRLLEEETLIDGVRVPGNTPLLF----STYVMGRMDTYFE-----DPLTFNPDRFGPG--APKPR 424

  Fly   433 CTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKF 468
            .|:.||..|.|:|||.:|..|:..|.:|.|::..:|
Human   425 FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	108/422 (26%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	109/433 (25%)