DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	536	Identity:	136/536 - (25%)
Similarity:	235/536 - (43%)	Gaps:	82/536 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLLLTLIALLVSLLLFMARRRHGYWQR-RGIPHD------VPHPIYGNMKDWPKKRHIAMIFRD- 58
            ::|:::..:|||    .||:    ||: |.||..      |.|.:|       .|.:.|..|:.
Mouse    28 TILISIFPMLVS----YARK----WQQMRSIPSVARAYPLVGHALY-------MKPNNAEFFQQL 77

  Fly    59 -YYTKYKRSV---------YPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRGIFYNEIDDP 113
             |||:..|.:         .|....|.......::|..:.:            ::...|..:...
Mouse    78 IYYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQI------------DKSFLYKFLQPW 130

  Fly   114 LSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQ-VLEIVDL 177
            |...|.:..|.|||..|..|||||....::|...::    .|...|...|......| .......
Mouse   131 LGLGLLTSTGSKWRTRRKMLTPTFHFTILENFLDVM----NEQANILVNKLEKHVNQEAFNCFFY 191

  Fly   178 VARYTADVIGNCAFGLNCNSLQNPNAEFV-TIGKRA-IIERRYGGL-----LDFLIFGFPKLSRR 235
            :.....|:|...|.|.|..:..|.::|:| |:.:.: :|.||....     |.:|:|...:..:|
Mouse   192 ITLCALDIICETAMGKNIGAQSNNDSEYVRTVYRMSDMIYRRMKMPWLWFDLWYLVFKEGRDHKR 256

  Fly   236 ------------LRLKLNVQDVEDFYTSIVRNTIDYRLRTNEKRHDFMDSLIEMYEKEQAGNTED 288
                        :..::..:..|:.:|...|..|.    :..||..|:|.|:.:.::|  ||.
Mouse   257 GLKCLHTFTNNVIAERVKERKAEEDWTGAGRGPIP----SKNKRKAFLDLLLSVTDEE--GNR-- 313

  Fly   289 GLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKE 353
             ||..:|..:...|...|.:|::..:.::||.|..:.::|.::..|::.|..:.:...|.|.:|:
Mouse   314 -LSQEDIREEVDTFMFEGHDTTAAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRPVTLEDLKK 377

  Fly   354 MKYLEQVVMETLRKYPVLAHLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFK 418
            :|||:.|:.||||.:|.:....|....|.  |...|.:.|||..:|....:|.||..:|:||:|:
Mouse   378 LKYLDCVIKETLRVFPSVPLFARSLSEDC--EVGGYKVTKGTEAIIIPYALHRDPRYFPDPEEFR 440

  Fly   419 PERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVK 483
            ||||..|....|....::||..|||||||.:|.:|:....||.::|  :|.|.:..:.....:..
Mouse   441 PERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILR--QFWVESNQKREELGLAG 503

  Fly   484 SILLSAENGIHLKVEK 499
            .::|...|||.:|:::
Mouse   504 DLILRPNNGIWIKLKR 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	123/489 (25%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	125/501 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820