Protein Alignment Cyp6a23 and Cyp3a59

DIOPT Version :10

• Sequence 1: NP_611000.2
• Gene: Cyp6a23 / 36661
• FlyBaseID: FBgn0033978
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001098630.1
• Gene: Cyp3a59 / 100041449
• MGIID: 3769707
• Length: 503
• Species: Mus musculus
• Alignment Length: 520
• Identity: 165/520 - (31%)
• Similarity: 264/520 - (50%)
• Gaps: 55/520 - (10%)

  Fly     6 TLIALLVSLLLF--MARRRHGYWQRRGIPHDVPHPIYGNMKD-----WPKKRHIAMIFRDYYTKY 63
            |.:.|:.||:.|  .....||.:::.|||...|.|::|.:.:     |       ....|.|.||
Mouse    11 TWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFDGMW-------KFDEDCYKKY 68

  Fly    64 KRSVYPFAGFYFFFTRSAVITDLELVKRVLIKD-FNHFENRGIFYNEIDDPLSATLFSI---EGQ 124
            .:    ..|||........|.|.|::|.||:|: ::.|.||...     .|:.....||   |.:
Mouse    69 GK----IWGFYVGPKPILAIMDPEIIKIVLVKECYSVFTNRPTL-----GPVGFLKKSITISEDE 124

  Fly   125 KWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNC 189
            :|:.||..|:|||||||:|.||||:.:.|:.:  :.:.:....:|:.:.:.|:...|:.|||...
Mouse   125 EWKRLRTLLSPTFTSGKLKEMFPIMRQYGDIL--VRNLRREEEKGEPINMKDIFGAYSMDVITGT 187

  Fly   190 AFGLNCNSLQNPNAEFVTIGKRAIIERRYGGLLDFLIFG--------FPKLS---RRLRLKLNVQ 243
            :||:|.:||.||...||...|:         :|.|.||.        ||.|:   ..|.|.:..:
Mouse   188 SFGVNIDSLNNPQNPFVQKTKK---------ILKFKIFDPFLLSTILFPFLTPIYEMLNLSIFPR 243

  Fly   244 DVEDFYTSIVRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGF 307
            |..:|:...|:.....||.:.:| |.||:..::.. :..:...::..||..|:.|||.||...|:
Mouse   244 DSMNFFKKFVKRMKKERLASKQKNRVDFLQLMMNT-QNSKGQESQKALSDLEMAAQAVIFIFGGY 307

  Fly   308 ETSSTTMGFALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLA 372
            :.:||::...:||||...|:|.:|:.||:..| .:....||:.:.:|:||:.||.|:||.||...
Mouse   308 DATSTSISLIMYELATHPDVQKKLQDEIDRTL-PNKAPVTYDALMDMEYLDMVVNESLRLYPTAI 371

  Fly   373 HLTRMTQTDFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLP 437
            .|.|:::.|.  |....||.|||.|:||...:|.:||.:|||::|.|.||:.|.........::|
Mouse   372 RLERVSKKDV--EINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDPYIYMP 434

  Fly   438 FGEGPRNCIGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKVEKLSK 502
            ||.|||||:.:||.|:...:.:..:::.:......|||||:| :.:..:...|..|.|||....|
Mouse   435 FGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQIPLK-ISREPVFQPEKPIILKVVSRDK 498

  Fly   503  502
            Mouse   499  498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	CYP6-like	68..494	CDD:410679	142/441 (32%)
Cyp3a59	NP_001098630.1	CYP3A	67..492	CDD:410743	145/449 (32%)