DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and Cyp3a41b

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001098629.1	Gene:	Cyp3a41b / 100041375	MGIID:	3714859	Length:	504	Species:	Mus musculus

Alignment Length:	507	Identity:	178/507 - (35%)
Similarity:	280/507 - (55%)	Gaps:	42/507 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIALLVSLLLFMARRRHGYWQRRGIPHDVPHPIYGNMKDWPKKRHIAMIFRDYYTKYKRSVYPFA 71
            |:|:::.||.....|.||.::::|||...|.|..|.:.::.|  .:.....:.|.||.::...|.
Mouse    14 LLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYK--GLWKFDMECYEKYGKTWGLFD 76

  Fly    72 GFYFFFTRSAVITDLELVKRVLIKD-FNHFENRGIFYNEIDDP---LSATLFSIEGQKWRHLRHK 132
            |....|    ||||.|::|.||:|: |:.|.||..|     .|   :|..:...:.::|:..|..
Mouse    77 GQMPLF----VITDPEMIKNVLVKECFSVFTNRREF-----GPVGIMSKAISISKDEEWKRYRAL 132

  Fly   133 LTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEGQVLEIVDLVARYTADVIGNCAFGLNCNS 197
            |:|||||||:|.|||:|.:.|:.:.|....:..  :|:.:.:.|::..|:.|||.:.:||:|.:|
Mouse   133 LSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAE--KGKPVTMKDVLGAYSIDVITSTSFGVNVDS 195

  Fly   198 LQNPNAEFVTIGKRAIIERRYGGLL--DF---LIFG---FPKLS---RRLRLKLNVQDVEDFYTS 251
            |.||...||...|         |:|  ||   |:|.   ||.|:   ..|.:.:..:|..:|:..
Mouse   196 LNNPEDPFVEKAK---------GILRVDFFDPLVFSVVLFPFLTPVYEMLNICMFPKDSIEFFKK 251

  Fly   252 IVRNTIDYRLRTNEK-RHDFMDSLIEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMG 315
            .|....:.||.:.:| |.||:..::..:...:..::...||..||.||:.:|..||:||:|:|:.
Mouse   252 FVNRMKESRLDSKQKHRVDFLQLMMNAHNNSKDKDSHKALSDMEITAQSIVFIFAGYETTSSTLS 316

  Fly   316 FALYELALDQDIQDQLRAEINNVLSKHNNEFTYEGIKEMKYLEQVVMETLRKYPVLAHLTRMTQT 380
            |.||.||...|||.:|:.||:..| .:....||:.:.||:||:.|:.||||.||:...|.|..:.
Mouse   317 FTLYCLATHPDIQKKLQEEIDETL-PNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKK 380

  Fly   381 DFSPEDPKYFIAKGTTVVIPALGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNC 445
            |.  |....:|.||:||:||:..:|:||:.:||||:|:||||:.|...:.....::|||.|||||
Mouse   381 DV--ELNGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSIDPYLYMPFGIGPRNC 443

  Fly   446 IGLRFGLMQACVGLAYLIRGYKFSVSTETQIPMKFVVKSILLSAENGIHLKV 497
            ||:||..|...:.|..:::.:.|....|||||:| :.:..||..|..|.|||
Mouse   444 IGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLK-LSRQGLLQPEKPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	165/474 (35%)
Cyp3a41b	NP_001098629.1	p450	39..494	CDD:278495	167/480 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.750