DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a23 and cyp4f3

DIOPT Version :9

Sequence 1:	NP_611000.2	Gene:	Cyp6a23 / 36661	FlyBaseID:	FBgn0033978	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001083010.1	Gene:	cyp4f3 / 100037390	ZFINID:	ZDB-GENE-070410-108	Length:	511	Species:	Danio rerio

Alignment Length:	491	Identity:	130/491 - (26%)
Similarity:	219/491 - (44%)	Gaps:	77/491 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 YGNMKDWPKKRHIAMIFRDYYTKYKRSVYPFAGFYFFFTRSAVITDLELVKRVLIKDFNHFENRG 104
            ||:...|.......|: |.::..|.||:         .|.||.||         :||       .
Zfish    69 YGHSCSWFLGPFYNMV-RLFHPDYIRSL---------LTASASIT---------LKD-------R 107

  Fly   105 IFYNEIDDPLSATLFSIEGQKWRHLRHKLTPTFTSGKMKNMFPIIVKVGEEMEKIFSAKTTTGEG 169
            |||..:...|...|....||:|...|..|||.|....:|....|..:....|...:......||.
Zfish   108 IFYGFMKPWLGNCLLLQSGQEWSRHRRLLTPAFHFDILKKYVHIFNQSTNIMHDEWRRLLAKGEH 172

  Fly   170 QVLEIVDLVARYTADVIGNCAFGLNCNSLQNPNAEFVTI--GKRAIIERRYGGLLDFLIFGFPKL 232
            .| ::.:.::..|.|.:..|.|..:.:|.:.|......|  ..|.:::|::     :|.:.:..|
Zfish   173 SV-DMFEQISSLTLDSLLKCTFSCDTHSQEKPRQYISAILDLSRLLVQRQH-----YLPYHWDWL 231

  Fly   233 ------SRRLRLKLNVQDVEDFYTSIVR-----------------NTIDYRLRTNEKRHDFMDSL 274
                  .||.:....|  |..|...||:                 ||..||.|.|.   |.:|.|
Zfish   232 YWRSAQGRRFQQACAV--VHQFTADIVQERRTQLDQQSDPESHPENTGRYRKRKNT---DLIDLL 291

  Fly   275 IEMYEKEQAGNTEDGLSFNEILAQAFIFFVAGFETSSTTMGFALYELALDQDIQDQLRAEINNVL 339
              :..|:..|   :||:..||.|.|.:|..||.:|:::.:.:..|.||::||.|::.|||:.::|
Zfish   292 --LLAKDDKG---EGLTNEEIKAHADMFMFAGHDTTASALSWIFYNLAMNQDYQERCRAEVRDLL 351

  Fly   340 S-KHNNEFTYEGIKEMKYLEQVVMETLRKY-PVLAHLTR-MTQTDFSPEDPKYFIAKGTTVVIPA 401
            : :..:...:|.:.::.:....:.|:||.: |||| ||| .:|...:|.|  ..|..|...:|..
Zfish   352 ADRDTHTIGWEDLSQLTFTTMCIKESLRLHSPVLA-LTRYYSQNMKTPGD--CVIPHGCLCLISI 413

  Fly   402 LGIHYDPEIYPEPEKFKPERFTDEAIAARPSCTWLPFGEGPRNCIGLRFGLMQACVGLAYLIRGY 466
            .|:|.:|:::|:|..|.|.||......:|....::||..|||||||..|.:.:..|.:|..:..:
Zfish   414 YGVHRNPQVWPDPLVFDPTRFDPHNSDSRSPHAFIPFSAGPRNCIGQNFAMAEMKVVVALTLARF 478

  Fly   467 KFSVSTETQIPMKFVVKSILLSAENGIHLKVEKLSK 502
            |.....:   |::.:.: ::|.||.|:.|..::|::
Zfish   479 KILPGPK---PVRRLYQ-LVLRAEGGMILHFQELNE 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a23	NP_611000.2	p450	36..495	CDD:278495	128/482 (27%)
cyp4f3	NP_001083010.1	p450	38..503	CDD:278495	128/482 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010