DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pcf11 and Pcf11

DIOPT Version :9

Sequence 1:	NP_610999.4	Gene:	Pcf11 / 36658	FlyBaseID:	FBgn0264962	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_006508335.1	Gene:	Pcf11 / 74737	MGIID:	1919579	Length:	1684	Species:	Mus musculus

Alignment Length:	1923	Identity:	468/1923 - (24%)
Similarity:	698/1923 - (36%)	Gaps:	578/1923 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RDDERRIGEEYLSSLQDLNCNSKPLINMLTMLAEENINYAHIIVKVVEYYISQVAPEFKLPILYL 73
            |:|..|   :|.|||:||..||||.|||||:|||||:.:|..||.::|...::.....|||::||
Mouse    15 REDACR---DYQSSLEDLTFNSKPHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYL 76

  Fly    74 IDSIVKNVKSSYVQLFGQCIVNIFLHAFESVQHSQSQVLEKVRERMYALRQTWNEVFPPSKMYAL 138
            :|||||||...|:..|.:.:|..|:..||.|.       |..|:.::.||.||:|:||..|:|||
Mouse    77 MDSIVKNVGREYLTAFTKNLVATFICVFEKVD-------ENTRKSLFKLRSTWDEIFPLKKLYAL 134

  Fly   139 DVKVKRLDNNWPITAKQPTNKIHVN-PAIHVNPDFLK--------PGLVPGMP--GNPTITSDME 192
            ||:|..||..|||....|    :|| .:|||||.||.        ||.|...|  ..|.|..|::
Mouse   135 DVRVNSLDPAWPIKPLPP----NVNTSSIHVNPKFLNKSPDEPSTPGTVVSSPSISTPPIVPDIQ 195

  Fly   193 ----------EILQAKTRELLELKKRKLELELEQTKKHLEEQERQLTQTTDAMVGAPIIMPAPTP 247
                      :.|.||.::||||:::||||||||.|..|........:|.:       :.|...|
Mouse   196 KNLTQEQLIRQQLLAKQKQLLELQQKKLELELEQAKAQLAVSLSVQQETAN-------LGPGSVP 253

  Fly   248 AAI-CPPITDPGIAVHNQRAPGVMGNVGPVMHNMPVAPQLFANKPKVHPVNPALLNSVRQRDPRL 311
            :.: .|.|  |.:||   :.|          |.:||.|......|.:...:....|    |||||
Mouse   254 SKLHVPQI--PTMAV---KTP----------HQVPVQPDKSRAGPSLQMQDLKGTN----RDPRL 299

  Fly   312 ARQMHAASSHPAAPARNDPRLEAKSSSSQKSSRSRSKSPVRNSSSRSGKSGSS------SHSSSS 370
            .|....:|.......|.:..:...:.|..|:|::.....:.:|.....|||..      ....|.
Mouse   300 NRMSQHSSHGKEQSHRKEFVMNTINQSDIKTSKNVPSEKLNSSKQEKSKSGERITKKELDQLDSK 364

  Fly   371 SRKRSESKSSTTSSSSSSSDVRHKG-----VTASSSNQPTVKR--SGKITSKDSDRYVRNGSPLG 428
            |:.:|:|.|...:..|.:.|::::.     ::..|...|.:|:  ..|...||.|  |:......
Mouse   365 SKSKSKSPSPLKNKLSHTKDLKNQDSESMRLSDMSKRDPRLKKHLQDKAEGKDED--VKEKRKTA 427

  Fly   429 SAKRKSSSPSSSPSK-----------------------SKRSTSHKSSSSRGKTSSLRSRSRSPV 470
            ..|.|.....||..:                       .|:.|....||:|.::.|...:||||:
Mouse   428 EKKEKDEHMKSSEHRVIGSRSKIINGIVQKQDMVTEELEKQGTKPGRSSTRKRSRSRSPKSRSPI 492

  Fly   471 FMDVDLRTGVRSKSPESRAVAPSSLPLAGASLPASAKAPKDLEKPTFQILEPGHPPAPPSPPIID 535
             :....|...||.....|:::|:..|.||....:..|.....|.|         ||:.....|..
Mouse   493 -IHSPKRRDRRSPKRRQRSMSPNLAPKAGKMRQSGLKQSHMEEFP---------PPSREERNIKR 547

  Fly   536 VSSMDI-DLRRPK----TPPPPTF---------DSVDSLDQ-------KDTTSGHISSTIIQASG 579
            .:..|: |.||.|    ..|..|.         |..::::.       |...||...:..:| .|
Mouse   548 SAKQDVRDPRRLKKMDEDRPQETAGQHSMKSGGDPKENIENWQSSKSAKRWKSGWEENKSLQ-QG 611

  Fly   580 ASNASP-------SGASTSKLPAKVSFKIQKQFNKLEKSTANLSTVSMLNSNPTTSGTPAA--SL 635
            ..::.|       |.:||..:   :|.:..||.::|... |||.....|        |.|:  .|
Mouse   612 DEHSKPPHLRHRESWSSTKGI---LSPRAPKQQHRLSVD-ANLQIPKEL--------TLASKREL 664

  Fly   636 VRQSSPSPSSSSISSQGNVSDALQLSINKLLQVQGGAGEKRPADALPPHIDGEEQPPQQKRSKSA 700
            ::::|...:|..|:....:....|  |.:|.|.|.|           .|.......|:::.....
Mouse   665 LQKTSERLASGEITQDEFLVVVHQ--IRQLFQYQEG-----------KHRCNVRDSPKEENKGGL 716

  Fly   701 KLDALFGSEDVDL----------RREILVVKPGVIVVEDDSMD-----------ECDVDKPTKKS 744
            |...|.  .|.:|          |.::....|.:.:::.|..|           ||:   |:|..
Mouse   717 KKKPLL--SDAELTYYEHKAKLKRTQVQHSFPRLDLLDPDIFDYPLTDALLSGIECE---PSKSK 776

  Fly   745 GSPPKKATLEELRAKLANSARIQNKQGKSDKSRDQAVSQRLKQLAELKVNDDSQEAHDEKVRTIL 809
                        .|...:.|:...|:..|:::|..:.....:..||.....:.:..|||:|..
Mouse   777 ------------HASRNSGAQFDRKEQFSERARRPSPISGSRTYAENLSPHEGRRRHDEQVSA-- 827

  Fly   810 SQAQEMYENNGMNQEQYKDLVQKVVAINENSKIKESRRRDND-------------LERN------ 855
                     .|:.:||..       ..|:...:|..|..|:|             |:.|
Mouse   828 ---------KGVREEQRS-------PFNDRFPLKRPRYEDSDKPFVDGPASRFAGLDTNQRLTAL 876

  Fly   856 ---------AARDAVLR------------KRIPKLKGNENHSAGSPHTDGSPRYDDQPAAAPEKP 899
                     ..|.:|.|            |..|::.|        |.|.||.|:|..|.......
Mouse   877 AEDRPLFDGPGRPSVTRDGPAKMIFEGPNKLSPRIDG--------PPTPGSLRFDGSPGQMGGGG 933

  Fly   900 SNKRDKTKREMKRRKPTKW-GEQVDAGAAQRTAWQLANVNNNNNNNNNKRGGIQLPVQPQAGFRG 963
            ..:.:..:.::....|.:: |.....|...|....:.....         ||.:....|...|.|
Mouse   934 PMRFEGPQGQLGGGCPLRFEGPPGPVGTPLRFEGPIGQGGG---------GGFRFEGSPSLRFEG 989

  Fly   964 M--------PWQQPPAMVL--GQSAVP--------PPPQPPSMISMPPVPPVTMTKAINSL--DN 1008
            .        |..||...:.  |....|        |..||                 :.||  ||
Mouse   990 STGGLRFEGPGGQPVGGLRFEGHRGQPVGGLRFEGPHGQP-----------------VGSLRFDN 1037

  Fly  1009 PMADVVRSITIDGG----SKEIRFYNQVAIIFMDGDQPHEIGFQP-------------------- 1049
            |....|..:..:||    ...|||           |.||.   ||
Mouse  1038 PRGQPVGGLRFEGGHGPSGAAIRF-----------DGPHG---QPGGGGGIRFEGPLLQQGVGMR 1088

  Fly  1050 -----GQRVI---FIDHNEPLPLCFNDDYKPFHLDGQLH----------RIRFGFPSRELYIDEH 1096
                 ||.|.   |..||:              |.|.|.          .|||..|     |.:.
Mouse  1089 FEGPHGQSVAGLRFEGHNQ--------------LGGNLRFEGPHGQPGVGIRFEGP-----IVQQ 1134

  Fly  1097 WYEIYFGGPA------VSVPIG------NKLHIIKAEGPP------PNVD--------------- 1128
            ...:.|.||.      :..|:|      ...|.::.:|.|      |..|
Mouse  1135 GGGMRFEGPVPGGGLRIEGPLGQGGPRFEGCHSLRFDGQPGQPSLLPRFDGLHGQPGPRFERTGQ 1199

  Fly  1129 IGRVRRDLVVGKINMIADAHTIVPLFLDARQQ------TFQLGA-----EQHSLQFVDSFQYALL 1182
            .|..|.|...|:  .:......||...|..|.      ...||.     :.|..|.::||.::
Mouse  1200 PGPQRFDGPPGQ--QVQPRFDGVPQRFDGPQHQQASRFDIPLGLQGTRFDNHPSQRIESFNHS-- 1260

  Fly  1183 DG-----------------QLQKME-YGGLPKGMMLNGGR------------------------- 1204
             |                 |.|:.| ....|:|...||..
Mouse  1261 -GPYNDPPGNTFNVPSQGLQFQRHEQIFDTPQGPNFNGPHGPGNQNFPNPINRASGHYFDEKNLQ 1324

  Fly  1205 -SCFIRFGTLPKGVIAGKTHVADMVYI-----------KTDAPAEPPKPPPIIVKPPPVVEQPKP 1257
             |.|..||.||..:..|....:..|..           :...|..|..|...|..|...:  ||.
Mouse  1325 SSQFGNFGNLPTPISVGNIQASQQVLTGVAQPVAFGQGQQFLPVHPQNPGAFIQNPSGGL--PKA 1387

  Fly  1258 APVAVAPISLPAAAAALESLNINDLFQKLVSSGIIGGATAAPTLPAADSSAAKEPTASATEPSTA 1322
            .|           ...|..:::|:||.||:.:||:                      ..::|.:|
Mouse  1388 YP-----------DNHLSQVDVNELFSKLLKTGIL----------------------KLSQPDSA 1419

  Fly  1323 SATVAPATLPAGPPAEPIKRIDLRKP-------ESIKTRQAAVVAVLYLGMQCSSCGVRFPPEQT 1380
            :|.|..|.....|..:..:..|...|       |.:|.|..:|:..||.|:||.|||:||...||
Mouse  1420 TAQVTEAVAQPPPEEDEDQNEDQDVPDLTNFTIEELKQRYDSVINRLYTGIQCYSCGMRFTTSQT 1484

  Fly  1381 IKYSQHLDWHFRQNRRERDSTRKATSRKWYYDLNDWRQYEEIEDVEEREKNFLEAQGQPGGVEAL 1445
            ..|:.|||||:||||.|:|.:||.|.|:|||.|.||.::|||.|:|||.|:....:.....|...
Mouse  1485 DVYADHLDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFFEKVHEEVVLKT 1549

  Fly  1446 DELSQQRSLDSPVPTCAAGRDDVDHCCDMCHEKFEQFYNEELEEWHLRSAIRVEDKIYHPLCYED 1510
            .|.::::...| ||...||..:   .|::|.|:|||:::||.|||||::||||:.|||||.||||
Mouse  1550 QEAAKEKEFQS-VPAGPAGAVE---SCEICQEQFEQYWDEEEEEWHLKNAIRVDGKIYHPSCYED 1610

  Fly  1511 YKASLN---PPTEVKSDQDVDMNNTDDNAMDTLIKVEDDEDEGTPNSSQPIFEDDDDDVIVLPNE 1572
            |:.:.:   .|:..|:..:..:     |.|..::|.|..|                      |.|
Mouse  1611 YQNTSSFDCTPSPSKTPVENPL-----NIMLNIVKNELQE----------------------PCE 1648

  Fly  1573 EPSVTEIVDDDDEDEYVPGNVTRADMGNESQDKTESNS 1610
            .|.|.|      |....|...:...:...::.||||::
Mouse  1649 SPKVKE------EQIDAPPACSEESVATPTEIKTESDT 1680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcf11	NP_610999.4	CID	17..134	CDD:239621	52/116 (45%)
		Siah-Interact_N	187..255	CDD:286164	23/78 (29%)
		Stathmin	736..>839	CDD:279209	17/102 (17%)
Pcf11	XP_006508335.1	CID_Pcf11	19..145	CDD:340779	56/125 (45%)
		PTZ00121	<311..471	CDD:173412	40/195 (21%)
		Med15	<981..>1328	CDD:312941	92/497 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838884
Domainoid	1	1.000	284	1.000	Domainoid score	I1631
eggNOG	1	0.900	-	-		E1_KOG2071
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2089
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47777
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004735
OrthoInspector	1	1.000	-	-		oto94463
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15921
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1755
SonicParanoid	1	1.000	-	-		X5074
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.980