DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pcf11 and PCF11

DIOPT Version :9

Sequence 1:	NP_610999.4	Gene:	Pcf11 / 36658	FlyBaseID:	FBgn0264962	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_001333342.1	Gene:	PCF11 / 51585	HGNCID:	30097	Length:	1686	Species:	Homo sapiens

Alignment Length:	1922	Identity:	459/1922 - (23%)
Similarity:	695/1922 - (36%)	Gaps:	574/1922 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RDDERRIGEEYLSSLQDLNCNSKPLINMLTMLAEENINYAHIIVKVVEYYISQVAPEFKLPILYL 73
            |:|..|   :|.|||:||..||||.|||||:|||||:.:|..||.::|...::.....|||::||
Human    15 REDACR---DYQSSLEDLTFNSKPHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYL 76

  Fly    74 IDSIVKNVKSSYVQLFGQCIVNIFLHAFESVQHSQSQVLEKVRERMYALRQTWNEVFPPSKMYAL 138
            :|||||||...|:..|.:.:|..|:..||.|.       |..|:.::.||.||:|:||..|:|||
Human    77 MDSIVKNVGREYLTAFTKNLVATFICVFEKVD-------ENTRKSLFKLRSTWDEIFPLKKLYAL 134

  Fly   139 DVKVKRLDNNWPITAKQPTNKIHVN-PAIHVNPDFLK--------PGLVPGMP--GNPTITSDME 192
            ||:|..||..|||....|    :|| .:|||||.||.        ||.|...|  ..|.|..|::
Human   135 DVRVNSLDPAWPIKPLPP----NVNTSSIHVNPKFLNKSPEEPSTPGTVVSSPSISTPPIVPDIQ 195

  Fly   193 ----------EILQAKTRELLELKKRKLELELEQTKKHLEEQERQLTQTTDAMVGA--------- 238
                      :.|.||.::||||:::||||||||.|..|........:|::...|:
Human   196 KNLTQEQLIRQQLLAKQKQLLELQQKKLELELEQAKAQLAVSLSVQQETSNLGPGSAPSKLHVSQ 260

  Fly   239 --PIIMPAPTPAAICPPITDPGIAVHNQRAPGVMGNVGPVMHNMPVAPQLFANKPKVHPVNPALL 301
              |:.:.||....:....:.||.::..|...|.  |..|.::.:   .|....|.:.|. ...|:
Human   261 IPPMAVKAPHQVPVQSEKSRPGPSLQIQDLKGT--NRDPRLNRI---SQHSHGKDQSHR-KEFLM 319

  Fly   302 NSVRQRDPRLAR-----QMHAASSHPAAPARNDPRLEAKSSSSQKSSRSRSKSPVRNSSS----- 356
            |::.|.|.:.::     :::::....:.......:.|.....|:..|:|:|.||::|..|
Human   320 NTLNQSDTKTSKTIPSEKLNSSKQEKSKSGEKITKKELDQLDSKSKSKSKSPSPLKNKLSHTKDL 384

  Fly   357 RSGKSGSSSHSSSSSRKRSESKSSTTSSSSSSSDVRHKGVTASSSNQPTVKRSGKITSKDSDRYV 421
            ::.:|.|...|..:.|.....|.....:.....||:.|..||.              .||.|.::
Human   385 KNQESESMRLSDMNKRDPRLKKHLQDKTDGKDDDVKEKRKTAE--------------KKDKDEHM 435

  Fly   422 RNGS-PLGSAKRK------SSSPSSSPSKSKRSTSHKSSSSRGKTSSLRSRSRSPVFMDVDLRTG 479
            ::.. .|..::.|      ....:.:....|:.|....||:|.::.|...:||||: :....|..
Human   436 KSSEHRLAGSRNKIINGIVQKQDTITEESEKQGTKPGRSSTRKRSRSRSPKSRSPI-IHSPKRRD 499

  Fly   480 VRSKSPESRAVAPSSLPLAGASLPASAKAPKDLEKPTFQILEPGHPPAPPSPPIIDVSSMDIDLR 544
            .||.....|:::|:|.|.||....:.|| ...:|:.|           |||
Human   500 RRSPKRRQRSMSPTSTPKAGKIRQSGAK-QSHMEEFT-----------PPS-------------- 538

  Fly   545 RPKTPPPPTFDSVDSLDQKDTTSGHISSTIIQASGASNASPSGASTSKLPAKVSFKIQKQFNKLE 609
                             ::|                        ..:|...|...:..::..|.|
Human   539 -----------------RED------------------------RNAKRSTKQDIRDPRRMKKTE 562

  Fly   610 KSTANLSTVSMLNSNPTTSGTPAASLVRQSSPSPSSSSISSQGNVSDALQLSINKLLQVQGGAGE 674
            :.....:|    |.:.|.|||.....|.....|.|:....|....:.:||       ||.
Human   563 EERPQETT----NQHSTKSGTEPKENVENWQSSKSAKRWKSGWEENKSLQ-------QVD----- 611

  Fly   675 KRPADALPPHIDGEEQ------------PPQQKRSKSAKLDALFGSE-DVDLRREILV-----VK 721
               ..:.|||:...|.            |.||:...|...:.....| .:..:||:|.     :.
Human   612 ---EHSKPPHLRHRESWSSTKGILSPRAPKQQQHRLSVDANLQIPKELTLASKRELLQKTSERLA 673

  Fly   722 PGVIVVED---------------DSMDECDV-DKPTKKS-GSPPKKATLE-------ELRAKLAN 762
            .|.|..:|               :....|:| |.||::: |...||..|.       |.:|||..
Human   674 SGEITQDDFLVVVHQIRQLFQYQEGKHRCNVRDSPTEENKGGLKKKPLLSDAELTYYEHKAKLKR 738

  Fly   763 S--------------------------ARIQNKQGKSDKS---------RDQAVSQRLKQL---- 788
            :                          :.|:.:..||..:         |.:..|:|.::|
Human   739 TQVQHSFPRLDLLDPDIFDYPLTDALLSGIECEPSKSKHASRNSGAQFDRKEQFSERARRLSPIS 803

  Fly   789 -----AELKVNDDSQEAHDEKVRTILSQAQEMYENNGMNQEQYKDLVQKVVAINENSKIKESRRR 848
                 ||.....:.:..|||:|..           .|:.:||..       ..|:...:|..|..
Human   804 GSRTYAENLSPHEGRRRHDEQVSA-----------KGVREEQRS-------PFNDRFPLKRPRYE 850

  Fly   849 DND-------------LERNAARDAVLRKRIPKLKGNENHSAG---------------SPHTDGS 885
            |:|             |:.|....|:...| |...|....|..               ||..||.
Human   851 DSDKPFVDSPASRFAGLDTNQRLTALAEDR-PLFDGPSRPSVARDGPTKMIFEGPNKLSPRIDGP 914

  Fly   886 P-----RYDDQPAAAPEKPSNKRDKTKREMKRRKPTKW-GEQVDAGAAQRTAWQLANVNNNNNNN 944
            |     |:|..|.........:.:..:.::....|.:: |.....|...|....:.....
Human   915 PTPASLRFDGSPGQMGGGGPLRFEGPQGQLGGGCPLRFEGPPGPVGTPLRFEGPIGQAGG----- 974

  Fly   945 NNKRGGIQLPVQPQAGFRGMPWQQPPAMVLGQSAVPPPPQPPSMISM---------------PPV 994
                ||.:....|...|.|.|.        |.....|..||...:..               |..
Human   975 ----GGFRFEGSPGLRFEGSPG--------GLRFEGPGGQPVGGLRFEGHRGQPVGGLRFEGPHG 1027

  Fly   995 PPVTMTKAINSLDNPMADVVRSITIDGG----SKEIRFYNQVAIIFMDGDQPHEIGFQPGQRVIF 1055
            .||...:    .|||....|..:..:||    ...|||           |.||.   |||..:.|
Human  1028 QPVGGLR----FDNPRGQPVGGLRFEGGHGPSGAAIRF-----------DGPHG---QPGGGIRF 1074

  Fly  1056 I--------------DHNEPLP-LCFNDDYKPFHLDGQLHRIRFGFPSRELYIDEHWYEIYFGGP 1105
            .              .|.:.:. |.|...:.  .|.|.|   ||..|..:..:.     |.|.||
Human  1075 EGPLLQQGVGMRFEGPHGQSVAGLRFEGQHN--QLGGNL---RFEGPHGQPGVG-----IRFEGP 1129

  Fly  1106 AV-----------SVPIG---------------NKLHIIKAEGPP------PNVD---------- 1128
            .|           |||.|               ...|.::.:|.|      |..|
Human  1130 LVQQGGGMRFEGPSVPGGGLRIEGPLGQGGPRFEGCHALRFDGQPGQPSLLPRFDGLHGQPGPRF 1194

  Fly  1129 ------IGRVRRDLVVGKINMIADAHTIVPLFLDARQQ------TFQLGA-----EQHSLQFVDS 1176
                  .|..|.|...|:  .:......||...|..|.      ...||.     :.|..|.::|
Human  1195 ERTPGQPGPQRFDGPPGQ--QVQPRFDGVPQRFDGPQHQQASRFDIPLGLQGTRFDNHPSQRLES 1257

  Fly  1177 FQY---------------ALLDG-QLQKME-YGGLPKGMMLNGGR-------------------- 1204
            ..:               |...| |.|:.| ....|:|...||..
Human  1258 VSFNQTGPYNDPPGNAFNAPSQGLQFQRHEQIFDSPQGPNFNGPHGPGNQSFSNPLNRASGHYFD 1322

  Fly  1205 ------SCFIRFGTLPKGVIAGKTHVADMVYIKTDAP---AEPPKPPPIIVKPPPVVEQPKPAPV 1260
                  |.|..||.:|..:..|....:..|......|   .:..:..|:..:.|..|:.|..|
Human  1323 EKNLQSSQFGNFGNIPAPMTVGNIQASQQVLSGVAQPVAFGQGQQFLPVHPQNPGFVQNPSGA-- 1385

  Fly  1261 AVAPISLPAAAA--ALESLNINDLFQKLVSSGIIGGATAAPTLPAADSSAAKEPTASATEPSTAS 1323
                  ||.|..  .|..:::|:||.||:.:||:                      ..::..:|:
Human  1386 ------LPKAYPDNHLSQVDVNELFSKLLKTGIL----------------------KLSQTDSAT 1422

  Fly  1324 ATVAPATLPAGPPAEPIKRIDLRKP-------ESIKTRQAAVVAVLYLGMQCSSCGVRFPPEQTI 1381
            ..|:..|....|..|..:..|...|       |.:|.|..:|:..||.|:||.|||:||...||.
Human  1423 TQVSEVTAQPPPEEEEDQNEDQDVPDLTNFTVEELKQRYDSVINRLYTGIQCYSCGMRFTTSQTD 1487

  Fly  1382 KYSQHLDWHFRQNRRERDSTRKATSRKWYYDLNDWRQYEEIEDVEEREKNFLEAQGQPGGVEALD 1446
            .|:.|||||:||||.|:|.:||.|.|:|||.|.||.::|||.|:|||.|:....:.....|....
Human  1488 VYADHLDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFFEKVHEEVVLKTQ 1552

  Fly  1447 ELSQQRSLDSPVPTCAAGRDDVDHCCDMCHEKFEQFYNEELEEWHLRSAIRVEDKIYHPLCYEDY 1511
            |.::::...| ||...||..:   .|::|.|:|||:::||.|||||::||||:.|||||.|||||
Human  1553 EAAKEKEFQS-VPAGPAGAVE---SCEICQEQFEQYWDEEEEEWHLKNAIRVDGKIYHPSCYEDY 1613

  Fly  1512 KASLN---PPTEVKSDQDVDMNNTDDNAMDTLIKVEDDEDEGTPNSSQPIFEDDDDDVIVLPNEE 1573
            :.:.:   .|:..|:..:..:     |.|..::|.|..|                      |.:.
Human  1614 QNTSSFDCTPSPSKTPVENPL-----NIMLNIVKNELQE----------------------PCDS 1651

  Fly  1574 PSVTEIVDDDDEDEYVPGNVTRADMGNESQDKTESNS 1610
            |.|.|      |....|...|...:...|:.|||:::
Human  1652 PKVKE------ERIDTPPACTEESIATPSEIKTENDT 1682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcf11	NP_610999.4	CID	17..134	CDD:239621	52/116 (45%)
		Siah-Interact_N	187..255	CDD:286164	24/88 (27%)
		Stathmin	736..>839	CDD:279209	29/155 (19%)
PCF11	NP_001333342.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148800
Domainoid	1	1.000	288	1.000	Domainoid score	I1578
eggNOG	1	0.900	-	-		E1_KOG2071
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2087
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47777
OrthoDB	1	1.010	-	-		D164040at33208
OrthoFinder	1	1.000	-	-		FOG0004735
OrthoInspector	1	1.000	-	-		oto90882
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15921
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1755
SonicParanoid	1	1.000	-	-		X5074
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.990