DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pcf11 and pcf11

DIOPT Version :9

Sequence 1:	NP_610999.4	Gene:	Pcf11 / 36658	FlyBaseID:	FBgn0264962	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	NP_001007308.1	Gene:	pcf11 / 492341	ZFINID:	ZDB-GENE-041114-175	Length:	1457	Species:	Danio rerio

Alignment Length:	1806	Identity:	454/1806 - (25%)
Similarity:	671/1806 - (37%)	Gaps:	562/1806 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RDDERRIGEEYLSSLQDLNCNSKPLINMLTMLAEENINYAHIIVKVVEYYISQVAPEFKLPILYL 73
            |:|..|   ||.|||:||..||||.|||||:||||||.:...||.::|..|::..|..|||:|||
Zfish     7 REDACR---EYQSSLEDLTFNSKPHINMLTILAEENIQFTKDIVAIIEAQIAKAPPVEKLPVLYL 68

  Fly    74 IDSIVKNVKSSYVQLFGQCIVNIFLHAFESVQHSQSQVLEKVRERMYALRQTWNEVFPPSKMYAL 138
            :|||||||..:|:::|.:.:||.|:..||.|.       |..|:.::.||.||:|:||..|:|||
Zfish    69 VDSIVKNVGGAYLEVFAKNLVNSFICVFEKVD-------EGTRKSLFKLRSTWDEIFPLKKLYAL 126

  Fly   139 DVKVKRLDNNWPITAKQPTNKIHVNPAIHVNPDFLKP-------GLVPGMPGNPTITSD--MEEI 194
            ||:|..:|..|||....|    :||.:|||||.||||       ...|  |..|::|.:  :.:.
Zfish   127 DVRVNSVDPAWPIKPLPP----NVNASIHVNPKFLKPTEETPPKPTPP--PPTPSLTQEQLIRQQ 185

  Fly   195 LQAKTRELLELKKRKLELELEQTKKHLEEQERQLTQTTDAMVGAPIIMPAPTPAAICPPITDPGI 259
            |.||.::||||:::|:||||||||..|                                ...|.:
Zfish   186 LLAKQKQLLELQQKKIELELEQTKAQL--------------------------------AASPSL 218

  Fly   260 AVHNQRAPGVMGNVGPVMHNMPVAPQLFANKPKVHPVNPALLNSVRQRDPRLAR----------Q 314
            |:::..:..|..|..|.::  |..|     .|:.....||....:..|||||.|          |
Zfish   219 ALNHHASAPVRFNASPKVN--PTVP-----VPQTKSWPPAPSEKLSTRDPRLNRSGTTAVNPKEQ 276

  Fly   315 MHAASSHPAAPA-RNDPRLEAKSSSSQKSSRSRSKSPVRNSSSRSGKSGSSSHSSSSSRKRSESK 378
            :......||||: :|.|....::||.:.:...:.:.|.:::|:...|                ||
Zfish   277 VTHKKESPAAPSFQNAPEKRGQASSERPAKLDKLRIPKKDNSAVEEK----------------SK 325

  Fly   379 SSTTSSSSSSSDVRHKGVTASSSNQPTVKRSG---------KITSKDSDRYVRNGSPLGSAKRKS 434
            |.:...|.....||.:|:.:..|....|.:..         ::.|||.|  ||.       |::|
Zfish   326 SKSMLPSGKVMPVRPRGLESEQSKSAEVNKKDPRLHKQMHERMDSKDED--VRE-------KKRS 381

  Fly   435 SSPSSSPSKSKRSTSHKSSSSRGKTSS-------------------------LRSRSRSPVFMDV 474
            |........||.....|.||:|||..:                         .|||||||.....
Zfish   382 SEKKDRDEGSKNLDHQKLSSNRGKLINGSVNKHEKLETFLKQEIKVNKANVRKRSRSRSPPVHSP 446

  Fly   475 DLRTGVRSKSPESRAVAPSSLPLAGASLPASAKAPKDLEKPTFQILEPGHPPAPPSPPIIDVSSM 539
            ..:....|...::|:::|.         |.|.|:         ::.:..|..|.|.|...|..:.
Zfish   447 KRKERRSSPKRKTRSISPP---------PKSGKS---------RLSKHPHDDAFPQPSARDERTK 493

  Fly   540 DI--DLRRPKTP----PPPTFDS----VDSLDQKDTTSGHISSTIIQASGASNASPSGASTSKLP 594
            ..  |.||||.|    |....|.    :.:.:.||...|    ...::....|..|..:.|....
Zfish   494 KSVPDSRRPKRPLEDRPAEKKDGSLQRISAAEHKDLKDG----KRWRSGWEENKHPKHSDTDLSH 554

  Fly   595 AKVSFKIQKQFNKLEKSTANLSTVSMLNSNPTTSGTP------------------AAS---LVRQ 638
            .::..:..|.:|              .|..|.|..||                  :||   |:|:
Zfish   555 GRMGIQKHKTWN--------------TNQRPPTPRTPKQHRLSVDSNIQIPEALHSASKRDLLRK 605

  Fly   639 SSPSPSSSSISSQGNVSDALQLSINKLLQVQGGAGEKRPADALPPHIDGEEQPPQQKRSKSAKLD 703
            :|...:...||:...:|.|.|  ||:|.|.|   .|::.:|:.....|....|   .|.|...:.
Zfish   606 ASKRRADGEISNDEFLSVAHQ--INQLFQYQ---EERQRSDSWDESCDEGVYP---SRKKQETIS 662

  Fly   704 ALFGSEDVDLRREILVVKPGVIVVEDDSMDECDVDKPTKKSGS---------PPKKATLEELRAK 759
            ..:....:.|||                   ..:.:|.::.|.         ||.    .|:..:
Zfish   663 DAYLEHKLKLRR-------------------TQLHRPVQRGGHLPLHEMYHYPPH----HEVSEQ 704

  Fly   760 LANSARIQNKQGKSDKSRDQAVSQRLKQLAELKVNDDSQEAHDEKVRTILSQAQEMYENN----G 820
            .:.|..:....|           ..:|.|::       .|.| .::....|.....:.|:    |
Zfish   705 YSESLDVHKMSG-----------DPIKPLSD-------HEDH-RRIDRPPSCTGSTFRNSPSPVG 750

  Fly   821 MNQEQYKDLVQKVVAINENSKIKESRRRDNDLERNAARDAVLRKRIPKLKGNENHSAGSP----- 880
            ::            .|...|.:....|..:..|.:...:..:..|..  ..|..||...|
Zfish   751 LD------------GICGKSTVLPFERPSSPSEMDQQPEGDISPRFE--SPNSVHSGTGPDDGPI 801

  Fly   881 HTDGSPRYD---DQPAAA---PEKPSNKRDKTKREMKRRKPTKWGEQVDAGAAQRTAWQLANVNN 939
            ..:|.||:|   :|..:.   .|.|.|....::      .||   .||:|........|..:...
Zfish   802 SVEGLPRHDHFLEQGRSGRIHGESPGNTPSHSE------GPT---TQVNAARHDGPIHQRFDRYK 857

  Fly   940 NNNNNNNKRGGIQLPVQPQAGFRGMPWQQPPAMVLGQSAVPPPPQPPSMISMPPVPPVTMTKAIN 1004
            |                |||.|.|      |:..:.:..:..||:       |.|||........
Zfish   858 N----------------PQAPFDG------PSSHMREPRLDGPPR-------PFVPPSRYESNTG 893

  Fly  1005 SLDNPMADVVRSITIDGGSKEIRFYNQVAIIFMDG---DQPHEIGFQ-----PGQRVIF----ID 1057
            .             .||....:||         .|   |.||.  |:     |.:.|.|    :.
Zfish   894 G-------------FDGSGGPVRF---------SGHRFDTPHH--FEQFPKAPERPVRFNNPQVS 934

  Fly  1058 HN-----EPLPLCFNDDYKPFHLDGQLHRIRF---------------------GFPSRELYIDEH 1096
            |.     ||..:.| |...|.|.|..:.:.||                     .||:|.:..||.
Zfish   935 HRPMRFVEPHNVRF-DSPTPVHYDHSMPQNRFVNPPRFDNPQMQQGPPGYEEPHFPARIINYDEQ 998

  Fly  1097 WYEIYFGGPAVSVPIGNKLH-------------IIKAEGPP----PNVDIGRVR------RDLVV 1138
            ...:.|..|...:...|.:.             ....:|||    ||:. .::|      .|...
Zfish   999 QGPVRFDNPTCGIRFENPVQPEPLRFDAPPVMPRYDPQGPPRYCGPNIP-NQLRPQEPTMYDQTQ 1062

  Fly  1139 GKINMIADAHTIVPLFLDARQQTFQLGAEQHSLQ------------------FVDSFQYALLDGQ 1185
            |:..|| :.....|.|......:|...|:|.|:|                  |..||:     ..
Zfish  1063 GQGPMI-NPTVPPPNFNMPPINSFGGPAQQFSMQQNVSQTSNFSVPVPTSSDFQGSFR-----PP 1121

  Fly  1186 LQKMEYGGLPKGMMLNGGRSCFIRFGTLPKGVIAGKTHVADMVYIKTDAPAEPPKPPPIIVKPPP 1250
            ......||:|:.||   |...|:                             |..|.|.  :|..
Zfish  1122 FPGPGVGGVPQPMM---GAQNFM-----------------------------PQNPMPF--QPVS 1152

  Fly  1251 VVEQPKPAPVAVAPISLPAAAAALESLNINDLFQKLVSSGIIGGATAAPTLPAADSSAAKEPTAS 1315
            ...||:|.|              |..:::|||..||:|:|||        .||...|.|..|:||
Zfish  1153 QFPQPEPEP--------------LRQIDVNDLMSKLISTGII--------KPAPTDSTADSPSAS 1195

  Fly  1316 ATEPSTASATVAPATLPAGPPAEPIKRIDLRKPE-------------SIKTRQAAVVAVLYLGMQ 1367
            .|               ...|.|..:..:..:.|             .:|.|..:::..||.|:|
Zfish  1196 QT---------------ISVPEEEEEEEEQEQEEDDSVPDLTGFILDDMKQRHESIITKLYTGIQ 1245

  Fly  1368 CSSCGVRFPPEQTIKYSQHLDWHFRQNRRERDSTRKATSRKWYYDLNDWRQYEEIEDVEEREKNF 1432
            |.|||:||...||..|:.|||||:||||.|:|.::|.|.|:|||.|.||.::|||.|:|||.|:.
Zfish  1246 CYSCGMRFTASQTDVYADHLDWHYRQNRSEKDISKKVTHRRWYYSLTDWIEFEEIADLEERAKSQ 1310

  Fly  1433 LEAQGQPGGVEALDELSQQRSLDSPVPTCAAGRDDVDHCCDMCHEKFEQFYNEELEEWHLRSAIR 1497
            ...:.....|:...|.:::|...|    ..|..|.|...|::|.|:||.::.||.|||||::|||
Zfish  1311 FFEKVHEEVVQKTQEAAKEREFQS----VKAAADVVHELCEICQEQFEMYWEEEEEEWHLKNAIR 1371

  Fly  1498 VEDKIYHPLCYEDYKASLNPPTEVKSDQDVDMNN-TDDNAMDTLIKVEDDEDEGTPNSSQPIFED 1561
            |::|.|||.||||||     .|....|.....|. ..:|.:...:|.|.|::....:..:   |.
Zfish  1372 VDEKTYHPSCYEDYK-----NTSSFMDTTPSPNKMLTENPLTAFLKQEQDDETSCSSIKE---EP 1428

  Fly  1562 DDDDVIVLPNEEPSVTEIVDDDDEDEYVPGNVTRADMGNESQDKTESNSET 1612
            .|||:     |.|.|.|                      |.|.|.|..|:|
Zfish  1429 ADDDM-----EAPMVKE----------------------EVQVKLEGESQT 1452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcf11	NP_610999.4	CID	17..134	CDD:239621	57/116 (49%)
		Siah-Interact_N	187..255	CDD:286164	18/69 (26%)
		Stathmin	736..>839	CDD:279209	15/115 (13%)
pcf11	NP_001007308.1	CID	11..122	CDD:239621	58/120 (48%)
pcf11	NP_001007308.1	SWIRM-assoc_2	<441..554	CDD:293105	26/134 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582730
Domainoid	1	1.000	404	1.000	Domainoid score	I681
eggNOG	1	0.900	-	-		E1_KOG2071
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	405	1.000	Inparanoid score	I1868
OMA	1	1.010	-	-		QHG47777
OrthoDB	1	1.010	-	-		D164040at33208
OrthoFinder	1	1.000	-	-		FOG0004735
OrthoInspector	1	1.000	-	-		oto41306
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15921
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1755
SonicParanoid	1	1.000	-	-		X5074
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.990