DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pcf11 and Pcf11

DIOPT Version :9

Sequence 1:	NP_610999.4	Gene:	Pcf11 / 36658	FlyBaseID:	FBgn0264962	Length:	1953	Species:	Drosophila melanogaster
Sequence 2:	XP_008757879.2	Gene:	Pcf11 / 361605	RGDID:	1563397	Length:	1867	Species:	Rattus norvegicus

Alignment Length:	1917	Identity:	467/1917 - (24%)
Similarity:	703/1917 - (36%)	Gaps:	568/1917 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RDDERRIGEEYLSSLQDLNCNSKPLINMLTMLAEENINYAHIIVKVVEYYISQVAPEFKLPILYL 73
            |:|..|   :|.|||:||..||||.|||||:|||||:.:|..||.::|...::.....|||::||
  Rat   200 REDACR---DYQSSLEDLTFNSKPHINMLTILAEENLPFAKEIVSLIEAQTAKAPSSEKLPVMYL 261

  Fly    74 IDSIVKNVKSSYVQLFGQCIVNIFLHAFESVQHSQSQVLEKVRERMYALRQTWNEVFPPSKMYAL 138
            :|||||||...|:..|.:.:|..|:..||.|.       |..|:.::.||.||:|:||..|:|||
  Rat   262 MDSIVKNVGREYLTAFTKNLVATFICVFEKVD-------ENTRKSLFKLRSTWDEIFPLKKLYAL 319

  Fly   139 DVKVKRLDNNWPITAKQP---TNKIHVNP--------------AIHVNPDFLKPGLVPGMPGNPT 186
            ||:|..||..|||....|   |:.|||||              .:..:|:...|.:||.:..|.|
  Rat   320 DVRVNSLDPAWPIKPLPPNVNTSSIHVNPKFLNKSPDEPSTPGTVVSSPNISTPPIVPDIQKNLT 384

  Fly   187 ITSDMEEILQAKTRELLELKKRKLELELEQTKKHLEEQERQLTQTTDAMVGAPIIMPAPTPAAI- 250
            ....:.:.|.||.::||||:::||||||||.|..|........:|.:       :.|...|:.:
  Rat   385 QEQLIRQQLLAKQKQLLELQQKKLELELEQAKAQLAVSLSVQQETAN-------LGPGSAPSKLH 442

  Fly   251 CPPITDPGIAVHNQRAPGVMGNVGPVMHNMPVAPQLFANKPKVHPVNPAL-LNSVR--QRDPRLA 312
            .|.|  |.:||   :.|          |.:||.|    :|.:   |.|:| :..::  .|||||.
  Rat   443 VPQI--PTMAV---KTP----------HQVPVQP----DKSR---VGPSLQMQDLKGTNRDPRLN 485

  Fly   313 RQMHAASSHPAAPARNDPRLEAKSSSSQKSSRSRSKSPVRNSSSRSGKSGSS------SHSSSSS 371
            |....:|.......|.:..:...:.|..|:|::.....:.:|.....|||..      ....|.|
  Rat   486 RMSQHSSHGKEQSHRKEFVMNTINQSDIKTSKTVPSEKLNSSKQEKSKSGERITKKELDQLDSKS 550

  Fly   372 RKRSESKSSTTSSSSSSSDVRH---KGVTASSSNQ--PTVKR--SGKITSKDSDRYVRNGSPLGS 429
            :.:|:|.|...:..|.:.|:::   :.:..|..|:  |.:|:  ..|...||.|  |:.......
  Rat   551 KSKSKSPSPLKNKLSHTKDLKNQESESMRLSDMNKRDPRLKKHLQDKAEGKDED--VKEKRKTAE 613

  Fly   430 AKRKSSSPSSSPSK-----------------------SKRSTSHKSSSSRGKTSSLRSRSRSPVF 471
            .|.|.....||..:                       .|:.|....||:|.::.|...:||||:
  Rat   614 KKDKDEHMKSSEHRLIGSRSKIINGVVQKQDMVTEELEKQGTKPGRSSTRKRSRSRSPKSRSPI- 677

  Fly   472 MDVDLRTGVRSKSPESRAVAPSSLPLAGASLPASAKAPKDLEKPTFQILEPGHPPAPPSPPIIDV 536
            :....|...||.....|:::|:..|.||....:..|.....|.|         ||:.....|...
  Rat   678 VHSPKRRDRRSPKRRQRSMSPTLAPKAGKMRQSGLKQSHMDEFP---------PPSREERNIKRS 733

  Fly   537 SSMDI-DLRRPK----TPPPPTF---------DSVDSLDQ-------KDTTSGHISSTIIQASGA 580
            :..|: |.||.|    ..|..|.         |..::::.       |...||...:..:| .|.
  Rat   734 AKQDVRDPRRLKKMDEDRPQETAGQHSMKSGGDPKENIENWQSSKSAKRWKSGWEENKSLQ-QGD 797

  Fly   581 SNASP-------SGASTSKLPAKVSFKIQKQFNKLEKSTANLSTVSMLNSNPTTSGTPAA--SLV 636
            .::.|       |.:||..:   :|.:..||.::|... |||.....|        |.|:  .|:
  Rat   798 EHSKPPHLRHRESWSSTKGI---LSPRAPKQQHRLSVD-ANLQIPKEL--------TLASKRELL 850

  Fly   637 RQSSPSPSSSSISSQGNVSDALQLSINKLLQVQGGAGEKRPADALPPHIDGEEQPPQQKRSKSAK 701
            :::|...:|..|:....:....|  |.:|.|.|.|           .|.......|:::.....|
  Rat   851 QKTSERLASGEITQDEFLVVVHQ--IRQLFQYQEG-----------KHRCNVRDSPKEENKGGLK 902

  Fly   702 LDALFGSEDVDL----------RREILVVKPGVIVVEDDSMD-----------ECDVDKPTKKSG 745
            ...|.  .|.:|          |.::....|.:.:::.|..|           ||:   |:|..
  Rat   903 KKPLL--SDAELTYYEHKAKLKRTQVQHSFPRLDLLDPDIFDYPLTDALLSGIECE---PSKSK- 961

  Fly   746 SPPKKATLEELRAKLANSARIQNKQGKSDKSRDQAVSQRLKQLAELKVNDDSQEAHDEKVRTILS 810
                       .|...:.|:...|:..|:::|..:.....:..||.....:.:..|||:|..
  Rat   962 -----------HASRNSGAQFDRKEQFSERARRLSPISGSRTYAENLSPHEGRRRHDEQVSA--- 1012

  Fly   811 QAQEMYENNGMNQEQYKDLVQKVVAINENSKIKESRRRDND-------------LERN------- 855
                    .|:.:||..       ..|:...:|..|..|:|             |:.|
  Rat  1013 --------KGVREEQRS-------PFNDRFPLKRPRYEDSDKPFVDGPASRFAGLDTNQRLTALA 1062

  Fly   856 --------AARDAVLR------------KRIPKLKGNENHSAGSPHTDGSPRYDDQPAAAPEKPS 900
                    ..|.:|.|            |..|::.|        |.|.||.|:|..|........
  Rat  1063 EDRPLFDGPGRPSVTRDGPTKMIFEGPNKLSPRIDG--------PPTPGSLRFDGSPGQIGGGGP 1119

  Fly   901 NKRDKTKREMKRRKPTKW-GEQVDAGAAQRTAWQLANVNNNNNNNNNKRGGIQLPVQPQAGFRGM 964
            .:.:..:.::....|.:: |.....|...|....:.....         ||.:....|...|.|.
  Rat  1120 MRFEGPQGQLGGGCPLRFEGPPGPVGTPLRFEGPIGQGGG---------GGFRFEGSPSLRFEGS 1175

  Fly   965 --------PWQQPPAMVL--GQSAVP--------PPPQPPSMISMPPVPPVTMTKAINSL--DNP 1009
                    |..||...:.  |....|        |..||                 :.||  |||
  Rat  1176 AGGLRFEGPGGQPVGGLRFEGHRGQPVGGLRFEGPHGQP-----------------VGSLRFDNP 1223

  Fly  1010 MADVVRSITIDGG----SKEIRFYNQVAIIFMDGDQPHEIGFQP--------------------- 1049
            ....|..:..:||    ...|||           |.||.   ||
  Rat  1224 RGQPVGGLRFEGGHGPSGAAIRF-----------DGPHG---QPGGGIRFEGPLLQQGVGMRFEG 1274

  Fly  1050 --GQRVI---FIDHNEPLPLCFNDDYKPFHLDGQLH----------RIRFGFPSRELYIDEHWYE 1099
              ||.|.   |..||:              |.|.|.          .|||..|     :.:....
  Rat  1275 PHGQSVAGLRFEGHNQ--------------LGGNLRFEGPHGQPGVGIRFEGP-----LVQQGGG 1320

  Fly  1100 IYFGGPA------VSVPIG------NKLHIIKAEGPP------PNVD---------------IGR 1131
            :.|.||.      :..|:|      ...|.::.:|.|      |..|               .|.
  Rat  1321 MRFEGPVPGGGLRIEGPLGQGGPRFEGCHSLRFDGQPGQPSLLPRFDGLHGQPGPRFERTGQPGP 1385

  Fly  1132 VRRDLVVGKINMIADAHTIVPLFLDARQQ------TFQLGA-----EQHSLQFVDSFQ----YAL 1181
            .|.|...|:  .:......||...|..|.      ...||.     :.|..|.::||.    |:.
  Rat  1386 QRFDGPPGQ--QVQPRFDGVPQRFDGPQHQQASRFDIPLGLQGTRFDNHPSQRIESFNQTGPYSD 1448

  Fly  1182 LDGQLQKMEYGGL-----------PKGMMLNGGR--------------------------SCFIR 1209
            ..|....:...||           |:|...||..                          |.|..
  Rat  1449 PPGNAFNVPSQGLQFQRHEQIFDTPQGPNFNGPHGPGNQNFPNPINRPSGHYFDEKNLQSSQFGN 1513

  Fly  1210 FGTLPKGVIAGKTHVADMVYI-----------KTDAPAEPPKPPPIIVKPPPVVEQPKPAPVAVA 1263
            ||.||..:..|....:..|..           :...|..|..|...|..|...:  ||..|
  Rat  1514 FGNLPTPMSVGNIQTSQQVLTGVAQPVAFGQGQQFLPVHPQNPGAFIQNPSGGL--PKAYP---- 1572

  Fly  1264 PISLPAAAAALESLNINDLFQKLVSSGIIGGATAAPTLPAADSSAAKEPTASATEPSTASATVAP 1328
                   ...|..:::|:||.||:.:||:                      ..::|.:|:|.|..
  Rat  1573 -------DNHLSQVDVNELFSKLLKTGIL----------------------KLSQPDSATAQVNE 1608

  Fly  1329 ATLPAGPPAEPIKRIDLRKP-------ESIKTRQAAVVAVLYLGMQCSSCGVRFPPEQTIKYSQH 1386
            |.....|..|..:..|...|       |.:|.|..:|:..||.|:||.|||:||...||..|:.|
  Rat  1609 AVAQPPPEEEEDQNEDQDVPDLTNFTIEELKQRYDSVINRLYTGIQCYSCGMRFTTSQTDVYADH 1673

  Fly  1387 LDWHFRQNRRERDSTRKATSRKWYYDLNDWRQYEEIEDVEEREKNFLEAQGQPGGVEALDELSQQ 1451
            ||||:||||.|:|.:||.|.|:|||.|.||.::|||.|:|||.|:....:.....|....|.:::
  Rat  1674 LDWHYRQNRTEKDVSRKVTHRRWYYSLTDWIEFEEIADLEERAKSQFFEKVHEEVVLKTQEAAKE 1738

  Fly  1452 RSLDSPVPTCAAGRDDVDHCCDMCHEKFEQFYNEELEEWHLRSAIRVEDKIYHPLCYEDYKASLN 1516
            :...| ||...||..:   .|::|.|:|||:::||.|||||::||||:.|||||.|||||:.:.:
  Rat  1739 KEFQS-VPAGPAGAVE---SCEICQEQFEQYWDEEEEEWHLKNAIRVDGKIYHPSCYEDYQNTSS 1799

  Fly  1517 ---PPTEVKSDQDVDMNNTDDNAMDTLIKVEDDEDEGTPNSSQPIFEDDDDDVIVLPNEEPSVTE 1578
               .|:..|:..:..:     |.|..::|.|..|                      |.|.|.|.|
  Rat  1800 FDCTPSPSKTPVENPL-----NIMLNIVKNELQE----------------------PCENPKVKE 1837

  Fly  1579 IVDDDDEDEYVPGNVTRADMGNESQDKTESNS 1610
                  |....|...:...:...::.||||::
  Rat  1838 ------EQIDAPPACSEESVATPTEIKTESDT 1863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pcf11	NP_610999.4	CID	17..134	CDD:239621	52/116 (45%)
		Siah-Interact_N	187..255	CDD:286164	21/68 (31%)
		Stathmin	736..>839	CDD:279209	17/102 (17%)
Pcf11	XP_008757879.2	CID_Pcf11	204..330	CDD:340779	56/125 (45%)
		Mplasa_alph_rch	<378..>653	CDD:275316	74/314 (24%)
		Med15	1174..>1497	CDD:312941	87/460 (19%)
		Med15	1434..>1578	CDD:312941	39/150 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342693
Domainoid	1	1.000	283	1.000	Domainoid score	I1562
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2051
OMA	1	1.010	-	-		QHG47777
OrthoDB	1	1.010	-	-		D164040at33208
OrthoFinder	1	1.000	-	-		FOG0004735
OrthoInspector	1	1.000	-	-		oto97976
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15921
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5074
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100