Protein Alignment Pcf11 and pcf11

DIOPT Version :9

• Sequence 1: NP_610999.4
• Gene: Pcf11 / 36658
• FlyBaseID: FBgn0264962
• Length: 1953
• Species: Drosophila melanogaster
• Sequence 2: NP_001123416.1
• Gene: pcf11 / 100170197
• XenbaseID: XB-GENE-5846364
• Length: 1698
• Species: Xenopus tropicalis
• Alignment Length: 1925
• Identity: 476/1925 - (24%)
• Similarity: 695/1925 - (36%)
• Gaps: 580/1925 - (30%)

  Fly     9 RDDERRIGEEYLSSLQDLNCNSKPLINMLTMLAEENINYAHIIVKVVEYYISQVAPEFKLPILYL 73
            |:|.||   :|.|||:||..||||.|||||:|||||:.:|..||.::|..|::.....|||::||
 Frog     8 REDARR---DYQSSLEDLTFNSKPHINMLTILAEENVQFAKDIVILIEAQIAKARATEKLPVMYL 69

  Fly    74 IDSIVKNVKSSYVQLFGQCIVNIFLHAFESVQHSQSQVLEKVRERMYALRQTWNEVFPPSKMYAL 138
            :|||||||...|:..|.:.:|..|:..||.|.       |..|:.:|.||.||:|:||..|:|||
 Frog    70 MDSIVKNVGRDYLAAFAKNLVTTFICVFEKVD-------ENTRKSLYKLRSTWDELFPSKKLYAL 127

  Fly   139 DVKVKRLDNNWPITAKQPTNKIHVN-PAIHVNPDFL-KPGLVP------GMPGNPTITS------ 189
            ||:|.::|..||:....|    :|| .:|||||.|| ||...|      ..|..|...:
 Frog   128 DVRVSQIDPAWPVKPLPP----NVNTSSIHVNPKFLNKPEESPPAKASAPSPAPPRAANSEAQKH 188

  Fly   190 -DMEEILQ----AKTRELLELKKRKLELELEQTKKHLEEQERQLTQTTDAMVGAPII------MP 243
             ..|::::    .|.::||||:::|||||||||::.|         .|......|::      ||
 Frog   189 LSQEQLIRQQLLVKQKQLLELQQKKLELELEQTREQL---------ATSLSSSKPVVSPKIPHMP 244

  Fly   244 APTPAAICPPITDPGIAVHNQRAPGVMGNVGPVMHNMPVAPQLFANKPKVHPVNPALLNSVRQRD 308
            ...|    ||:::      ..:.|.....:......|||.                      .||
 Frog   245 VKAP----PPVSE------KSKVPAPTQRIEKSHEKMPVP----------------------TRD 277

  Fly   309 PRLAR-QMHAA----SSH---------------PAAPARNDPRLEAKSSSSQKSSRSRSKSPVRN 353
            |||.: ..|:|    ..|               |..|..||   :|.:|:.|:.::|..|.|.|.
 Frog   278 PRLVKGNQHSAHGKDQGHKKEMKSNMACMPDLKPIKPLLND---KANASAKQEKAKSNEKLPKRE 339

  Fly   354 SSSRSGKSGSSSHSS-----SSSRKRSESKSSTTSSSSSSSDVR-HKGVTASSSN---QPTVKR- 408
            ......|..|.|.|.     |..|.:|:...:......|..|.| ||.:...|.:   :|..||
 Frog   340 LVQSELKDRSKSPSPLKAKLSHMRDKSQGTENVRDLDISRRDPRLHKHLRNKSDDKDAEPKEKRK 404

  Fly   409 -SGKITSKDSDRYVRN-GSPLGSAKRKSSSPSSSPSKSKRSTSHKSSSSRGKTSSLRSRSRSPVF 471
             ..|...|...|...| ..|:.....|:.:.::.|.|:|.........||...|  ||.:.||..
 Frog   405 CDKKEEHKSEHRVAGNRNKPVNGIVPKNETSTNYPDKTKPGRIGNRKRSRSPKS--RSPAHSPKG 467

  Fly   472 MDVDLRTGVRSKSPESRAVAP-SSLPLAGASLPASAKAPKDLEKPTFQILEPGHPPAPPSPPIID 535
            .|      .||.....|:::| .|||..|                  ::.:||...:....  .:
 Frog   468 RD------RRSPKARPRSISPVHSLPKIG------------------RLRQPGSKQSHTED--FN 506

  Fly   536 VSSMDIDLRR-PKTPPPPTFDSVDSLDQKDTTSGHISSTIIQASGASNASPSGASTSKLPAKVSF 599
            .||.:..::| .||      |:.|...||..:.......:...|..||..|
 Frog   507 ASSREERIKRNAKT------DARDGRRQKRLSEERPQDPVSLISNKSNTEP-------------- 551

  Fly   600 KIQKQFNKLEKSTANLSTVSMLNSNPTTSGTPAASLVRQSSPSPSSSSISSQGNVSDALQLSINK 664
              ::.....:...||....|....|..:....     .|.:..|.....|.|.:
 Frog   552 --KEDIENWQGPKANKRWKSGWEDNKNSQNDD-----HQGNRPPYQRHNSWQNS----------- 598

  Fly   665 LLQVQGGAGEKRPADALPPHIDGEEQPPQQKRSKS-----AKLDALFGSEDVDLRREILVVKPGV 724
               .:|.|..:.|.......:|.:.:.|::..|.|     .|.:..|...:: ...|:|||...:
 Frog   599 ---TKGVASPRAPKQQHWLSVDADLKIPKELTSASKAELLKKANERFSLGEI-THDELLVVVHQI 659

  Fly   725 ---IVVEDDSMDECDVDKPTKKS-GSPPKK-------ATLEELRAKL------------------ 760
               ...:::.......|.||::: |:..||       .|..|.:|||
 Frog   660 RQLFQYQEEKQRGSVWDSPTEENKGALRKKPLLSNPETTYYEHKAKLKRTQVQHAFADREYMDPE 724

  Fly   761 ---------ANSARIQNKQGKS-DK--SRDQAVSQRLKQLAELKVNDDSQEAHD-----EKVRTI 808
                     |:|.|.....|:: ||  .|::...:|.:....|......::|||     |..|.:
 Frog   725 YLDMELDEMAHSGRDGELSGRAEDKMPERNEQFPERQRLSPLLGTRHPDEDAHDGYRRHEDQREL 789

  Fly   809 LSQAQEMYENNGMNQEQYKDLVQKVVAINENSKIKESRRRDNDLERNAARDAVLRKRIPKLKGNE 873
            ....:|  |...:..|::.   :.|...:|:.:.......|:.:..|.|.        |||...|
 Frog   790 SKGLRE--EPRPLFPERFP---RSVPMYDESEEAPYEENADSRMSGNKAN--------PKLPLME 841

  Fly   874 NHSAGSPHTDGSPRYDDQPAAAP-----EKPSNKRDKTKREMK------------------RRKP 915
            ..   .|..|..|........||     |:|||..:  .||..                  :|..
 Frog   842 ER---RPLLDIPPLIPVNRGDAPILKSFEEPSNVAN--VRESSPVNACMPFDGASGNQVGPQRFE 901

  Fly   916 TKWGEQVDAGAAQRTAWQLANV----------NNNNNNNNNKRGGIQ---------LPVQPQAGF 961
            ...|:.|||......|.|:.|.          |:.......|..|.|         :.|:...|.
 Frog   902 AVSGQPVDAHFDSMGANQVENTRFDGMMGQPKNHQGPQGMQKYDGAQNQPIVSSQPVGVKRLEGP 966

  Fly   962 RGMP-----WQQPPAMVLG----QSAVPPPPQPPSMISMPPVPP-----VTMTKAINSLDNPMAD 1012
            .|.|     ::.||:..||    :.|...|..|.....|..:.|     |...:..:....|:..
 Frog   967 PGQPMNAARFEGPPSQQLGAPRFEGAAGQPVGPQRFEGMQQLGPQRFEGVAGPQRFDGSPRPLMQ 1031

  Fly  1013 VVRSITIDG------------------GSK--EIRFYNQVAIIFMDGDQPHEIGFQPGQRVIFID 1057
            .    ..||                  |.:  .:||...|...| :.:||......||
 Frog  1032 Q----RFDGIPCQPMRFEQPMRFEASQGQQLGPVRFEGPVGPRF-EVNQPQRFDSGPG------- 1084

  Fly  1058 HNEPLPLCFND----DYKPFHLDG---------QLHRIRFGFPSRELYIDEHWYEIYFGGPAVSV 1109
               |.||...|    ..:| ..||         :.|..||..|.:...        .|.||
 Frog  1085 ---PQPLMRFDGPMGQMRP-RFDGTPGNRFDNQRPHMQRFDMPGQPCQ--------RFEGP---- 1133

  Fly  1110 PIGNKLHIIKAEGP----PPNVDIGRVRRDLVVGKINMIADAHTIVPLFLDA--RQQTFQLG--- 1165
                        ||    ||..|          |.:.:.......:|...|.  :|..|:|.
 Frog  1134 ------------GPGHQTPPRFD----------GPMQVQPRFDGPLPQRFDGPNQQPRFELSMNH 1176

  Fly  1166 -----------AEQHSLQFVDSFQYA----LLDGQLQKM---------------------EYGGL 1194
                       ..|::..|..|..|.    ...||.|.|                     ..|.|
 Frog  1177 QGPRFDNIHPPVRQNAPPFGQSGPYGEPQNHFHGQPQNMPPQGLPPQGMLPQGLPHQGMQPQGLL 1241

  Fly  1195 PKGMMLNG-------------------------------------------------GRSC---- 1206
            |:||:.||                                                 |..|
 Frog  1242 PQGMLPNGMQPQGMLPQGMPPQGIPPQGMQQQGMPLQRPEQRFDLPQGPNFAGPSGPGVQCFPNQ 1306

  Fly  1207 --------------------FIRFGTLPKGVIAGKTHVADMVYIKTDAPAEPPKP-----PPIIV 1246
                                |..|..||.|.:               ||::|..|     .|..:
 Frog  1307 LPRPSGPYFDDKNPKPQGPQFANFNNLPVGNL---------------APSQPFGPLGGMSQPAGI 1356

  Fly  1247 KPPPVVEQP----KPAPVA-----VAPI------------SLPAAAAALESLNINDLFQKLVSSG 1290
            ..|..:.||    :||..:     |.|:            |.|.....|..|::|:||.||:|:|
 Frog  1357 SQPTAISQPSGMSQPAFSSQDQNYVPPLGSAGGVFVQPGGSFPFPENHLGQLDVNELFSKLLSTG 1421

  Fly  1291 IIGGATAAPT--LPAADSSAAKEPTASATEPSTASATVAPATLPAGPPAEPIKRIDLRKPESIKT 1353
            ||...|...|  ..|.:|||   |.|:..|...|...        |...:.:..:...:.|.:|.
 Frog  1422 IIQKVTPNETSSTQATESSA---PAAAEEEEEDADGD--------GDEDQDVPDLTTFQMEDLKQ 1475

  Fly  1354 RQAAVVAVLYLGMQCSSCGVRFPPEQTIKYSQHLDWHFRQNRRERDSTRKATSRKWYYDLNDWRQ 1418
            |..:|:..||.|:||.|||:||...||..|:.|||||:||||.|:|.:||.|.|:|||.|.||.:
 Frog  1476 RYDSVINRLYTGIQCYSCGMRFTKSQTDIYADHLDWHYRQNRTEKDVSRKITHRRWYYSLKDWIE 1540

  Fly  1419 YEEIEDVEEREKN-FLEAQGQPGGVEALDELSQQRSLDSPVPTCAAGRDDVDHCCDMCHEKFEQF 1482
            :|||.|:|||.|: |.|...:...::..:...::..|.  ||...||.|::   |::|.|:|||:
 Frog  1541 FEEIADLEERAKSQFFEKVHEEVILKTQEAAKEKEFLS--VPAGPAGADEI---CEICQEQFEQY 1600

  Fly  1483 YNEELEEWHLRSAIRVEDKIYHPLCYEDYKASLNPPTEVKSDQDVDMNNTDDNAMDTLIKVEDDE 1547
            ::||.|||||::|:|:.||||||.||||||.:.:......|.....:.| ..|||..|:|.|..|
 Frog  1601 WDEEEEEWHLKNAMRMNDKIYHPSCYEDYKNTSSFLDSTPSPSKTLLEN-PLNAMLNLVKEEVTE 1664

  Fly  1548 DEGTPNSSQPIFEDDDDDVIVLPNEEPSVTEIVDDDDEDE 1587
                |..|  :.|:..|.......|.|.:|||..:..|.|
 Frog  1665 ----PTCS--VKEEPADYTASSCCEIPLLTEIKKEPAEPE 1698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pcf11	NP_610999.4	CID	17..134	CDD:239621	54/116 (47%)
		Siah-Interact_N	187..255	CDD:286164	23/84 (27%)
		Stathmin	736..>839	CDD:279209	29/145 (20%)
pcf11	NP_001123416.1	CID_Pcf11	12..138	CDD:340779	64/135 (47%)
		PTZ00121	<319..796	CDD:173412	110/548 (20%)
		Med15	911..>1357	CDD:312941	85/510 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I1637
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	379	1.000	Inparanoid score	I2023
OMA	1	1.010	-	-		QHG47777
OrthoDB	1	1.010	-	-		D164040at33208
OrthoFinder	1	1.000	-	-		FOG0004735
OrthoInspector	1	1.000	-	-		oto104667
Panther	1	1.100	-	-	LDO	PTHR15921
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1755
SonicParanoid	1	1.000	-	-		X5074
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.200