Protein Alignment HPS1 and hps1

DIOPT Version :10

• Sequence 1: NP_610997.1
• Gene: HPS1 / 36656
• FlyBaseID: FBgn0033973
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_001032777.2
• Gene: hps1 / 563067
• ZFINID: ZDB-GENE-051113-152
• Length: 668
• Species: Danio rerio
• Alignment Length: 696
• Identity: 187/696 - (26%)
• Similarity: 288/696 - (41%)
• Gaps: 154/696 - (22%)

  Fly     1 MNGLIVFNSANDVVYQKLNEPLAQKIR-----SVATTQGLLQSGGSLDSNILLQIFSPIVGSQRI 60
            |..|:|.|.:.:|::...:....|:::     |....:||.....|:::     :|:||:.|...
Zfish     1 MKCLLVANESAEVLFYWTDSEFEQRLQEQYGVSQEEGEGLPAFEDSINT-----LFAPIIISCST 60

  Fly    61 MQCQFDNAYSSLQCEQGFNLV---FGELLGFTFLKIGQIPVELLGRQMGVAITLTRYCYGANLFA 122
            |..:..:.|:|...|.....|   |.|.|.......|:...|.|.|::.|...||...:|  :..
Zfish    61 MVDRLGDNYTSFSTENNHIYVLHQFDECLYIAVNGDGEETEEDLKRKIYVMKKLTEILFG--MVT 123

  Fly   123 AQAGAMQQEL--------------LTQCLDCYETLLWEEDQTYLLEAMPRLLINTELKRTVHLTL 173
            .....:::||              |...|:.|..|. |.||::|:||:.||:..|..::.:.. |
Zfish   124 LSGPLLRKELRPQDTEQRNRLWKKLRSLLETYSRLR-ENDQSFLVEAVERLIHPTLCEQCIEF-L 186

  Fly   174 DATLEHLRQLGLPRA-----HALLLVSNKLVAANSTRQALPLAAADLLFLSLMSRALQAPK---- 229
            :..|.......:.||     ||.:||..|.:|..|:|.|..|..:|||.|.::.:.|...|
Zfish   187 ERRLVQQINSSMDRAGEEVLHAFILVHTKQLAFYSSRNASNLNPSDLLALIILVQDLYPSKIDLD 251

  Fly   230 --------------------SPSQR--------AVAVFLQGVSYDVNSG---------------- 250
                                ||.:|        :..|| |.|..|:...
Zfish   252 DTPEELENSTVPDVFYTPEPSPPERESVTPRKDSPPVF-QFVDPDIQMAEDSLQTLEVSTPDPSS 315

  Fly   251 ----------CVPSIVH----ISRLHG-NQVLLQVIEYAHMPLTSCIY---DSFFVLQKIVAVQH 297
                      | |.:.|    :|...| ..|||..|..:||.::  :|   ::|..|:|.:...|
Zfish   316 PSRVFLEAKEC-PMMPHSMYCLSLWPGITLVLLTKIPNSHMAVS--VYYFLEAFVKLEKRLGEGH 377

  Fly   298 QGDS-----DALKPAFENLESFIVQALTALKRYLKQRSETDDLENCTKKFAAKWENLR-KMYTEY 356
            :|.|     .:::.....||.||       |.:.....:|..|:|.       |.:.: |.::..
Zfish   378 EGASAMRGQSSVQEQRSKLEKFI-------KAWSSMEIQTLQLQNA-------WTDFKNKAFSRS 428

  Fly   357 FKNFERELLVRIESNLPSFGEELKQIFTLACCDSSSVHELDQLSDTAAN-VEAKLLEFAEFLAVK 420
            ...|.|:||....:.........:|.|...|..||. .....|.:.|.| |:.||:::.:||.||
Zfish   429 GTGFTRDLLPSCRNMKTQLCGVYRQFFAAECMGSSQ-RLAPHLQERALNMVQEKLMDWKDFLLVK 492

  Fly   421 ATRNISIDAYLEDFPGLVHFMYVNRSRGQMLAPDLR------------PNQLVPKTKLWSMVEIA 473
            :.|||::.:|||:||||:||:||:||.|||:||.|.            |.....|.|:||:|..|
Zfish   493 SKRNITMVSYLEEFPGLIHFIYVDRSSGQMIAPSLNVTDRTVSELGKGPLADFIKKKVWSLVATA 557

  Fly   474 RNYLKKGQTTVMWKDKAFHYSYFLWFEDMSGGVLSTVVDLQHHFLSTGAASGNGSKSPTEP-GAL 537
            |.||.||..||..:|..:.|.||||||:.:|..|. |.|:.            .....|.| |.|
Zfish   558 RRYLHKGYATVTLRDGDYFYCYFLWFENETGYKLE-VTDIP------------SCPDDTAPIGML 609

  Fly   538 TMDYYHDLAELCFPKLSPAKVRVYELYCIHLGLVTATCAVEHARRL 583
            |.|||..|......|.....|:.|||..:|||::.....::|..:|
Zfish   610 TFDYYRKLLRYYSKKHQNEVVKCYELLTVHLGVIPNEYILQHCSQL 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPS1	NP_610997.1	Fuz_longin_1	2..143	CDD:465953	34/162 (21%)
		Fuzzy	186..289	CDD:477403	39/173 (23%)
		Fuz_longin_3	436..587	CDD:465955	59/161 (37%)
hps1	NP_001032777.2	Fuz_longin_1	2..158	CDD:465953	34/162 (21%)
		Fuz_longin_2	203..>255	CDD:465954	16/51 (31%)
		Fuz_longin_3	508..661	CDD:465955	59/161 (37%)