Protein Alignment HPS1 and hps1

DIOPT Version :10

• Sequence 1: NP_610997.1
• Gene: HPS1 / 36656
• FlyBaseID: FBgn0033973
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_001006903.1
• Gene: hps1 / 448750
• XenbaseID: XB-GENE-977903
• Length: 669
• Species: Xenopus tropicalis
• Alignment Length: 725
• Identity: 168/725 - (23%)
• Similarity: 296/725 - (40%)
• Gaps: 207/725 - (28%)

  Fly     1 MNGLIVFNSANDVVYQKLNEPLAQKIRS---VATTQGLLQSGGSLDSNILLQIFSPIVGSQRIMQ 62
            |..:::.:...:|::...:|...:.::|   ....|.....|.|:::     :|:|::.|...:.
 Frog     1 MKCVLIASEGAEVLFYWADEEFEKNLQSKYDYTEEQQPPNYGDSINT-----LFAPLIISCVTIM 60

  Fly    63 CQFDNAYSSLQCEQGFNLV---FGELLGFTFLKIGQIPVEL---LGRQMGVAITLTRYCYGANLF 121
            .:.::.|:....|:|...|   |||.|   ::.:.....|.   |.|::.|...|....:|...|
 Frog    61 EKINDTYTCFTTEKGHLCVLHMFGECL---YIAVNGDETENEDDLRRKLYVLKRLCEVHFGLVTF 122

  Fly   122 AAQ--------AGAMQQELLTQCLDCYETLLW------EEDQTYLLEAMPRLLINTEL------- 165
            .:.        |.:.|:.|:.:   .:::||.      .|||::.:||:.| ||:.:|
 Frog   123 DSHLIKKELRPADSEQRNLVWK---TFQSLLLTYSRLRNEDQSFAVEAVER-LIHPKLCEQCIEF 183

  Fly   166 --KRTVHLTLDATLEHLRQLGLPRAHALLLVSNKLVAANSTRQALPLAAADLLFLSLMSRAL--- 225
              |:.||....::.....::    .||.:||:.||:|..|:|.|..|..||||.|.|:.:.|
 Frog   184 LEKQIVHFINSSSERGAEEV----LHAFVLVNTKLLALFSSRNASSLRPADLLSLILIVQDLYPN 244

  Fly   226 -------------QAPK--------SPSQRAVA-------------------------------- 237
                         .||.        ||:.|:::
 Frog   245 FSTQERNVEENEDNAPSEEYYTPDPSPNNRSLSGGSWVDDDSPALSYVDPEIQIAEDSLKTLVGD 309

  Fly   238 ---------VFLQGVSYDVNSG----------CVP-----SIVHISRLHGNQVLLQVIEYAHMPL 278
                     |||...   :..|          |:|     |:|.:::|.|:.:.|.:.:
 Frog   310 IPESTNTRRVFLDAT---LKEGYCPMMPHSMYCLPLWPGISLVLLTKLSGSHIALSLYQ------ 365

  Fly   279 TSCIYDSFFVLQKIVAVQHQGDSDALKPAFENLESFIVQALTALKRYLKQRSE---------TDD 334
               :.|.|.:|:|  .:...||...:      |.|..:.|      .||||::         ...
 Frog   366 ---LLDGFSMLEK--KLTEGGDIHQI------LRSHPIAA------DLKQRTDRFVKSLGGRDSQ 413

  Fly   335 LENCTKKFAAKWENLRKMYT-----EYFKNFERELLVRIESNLPSFGEELKQIFTLACCDSSSVH 394
            |:||..:|.:|..:.:...|     ...:|..|:|.           ...:|:|.::....:...
 Frog   414 LQNCWLEFKSKAFSRQDTGTVPELLHACRNMNRQLC-----------SVYRQLFLVSLMSGTHSL 467

  Fly   395 ELDQLSDTAANVEAKLLEFAEFLAVKATRNISIDAYLEDFPGLVHFMYVNRSRGQMLAPDLRPNQ 459
            .|:..|.....|:.||.::.|||.||:.||.::..||||||||:||:||:|:.|||:||.:..:.
 Frog   468 SLNMQSKVRKLVQGKLTDWQEFLLVKSKRNTTMVNYLEDFPGLIHFIYVDRTVGQMVAPSINTDS 532

  Fly   460 LVP------------KTKLWSMVEIARNYLKKGQTTVMWKDKAFHYSYFLWFEDMSGGVLSTVVD 512
            ...            |.|:||.:.::|.||:||.||:..:|..::..||||||:.:|..|. :::
 Frog   533 KTSSELGTGLLASFIKNKVWSFIGLSRRYLQKGYTTLTLRDGDYYCCYFLWFENEAGDKLE-IIE 596

  Fly   513 LQHHFLSTGAASGNGSKSPTEPGALTMDYYHDLAELCFPKLSPAKVRVYELYCIHLGLVTATCAV 577
            :        ...|:.| :|.  |.|..:||..|............|:.|||..:|||::.....:
 Frog   597 V--------PVLGDDS-API--GMLAGEYYRKLLRYYSKNHQTELVKCYELLTLHLGIIPPEFVI 650

  Fly   578 EH----ARRL 583
            :.    ||:|
 Frog   651 QQCHDLARKL 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPS1	NP_610997.1	Fuz_longin_1	2..143	CDD:465953	27/157 (17%)
		Fuzzy	186..289	CDD:477403	36/182 (20%)
		Fuz_longin_3	436..587	CDD:465955	50/164 (30%)
hps1	NP_001006903.1	Fuz_longin_1	2..156	CDD:465953	29/164 (18%)
		Fuz_longin_2	201..>252	CDD:465954	18/54 (33%)
		Fuz_longin_3	509..662	CDD:465955	50/164 (30%)