DRSC/TRiP Functional Genomics Resources

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Protein Alignment HPS1 and HPS1

DIOPT Version :10

Sequence 1:NP_610997.1 Gene:HPS1 / 36656 FlyBaseID:FBgn0033973 Length:596 Species:Drosophila melanogaster
Sequence 2:NP_000186.2 Gene:HPS1 / 3257 HGNCID:5163 Length:700 Species:Homo sapiens


Alignment Length:697 Identity:181/697 - (25%)
Similarity:275/697 - (39%) Gaps:216/697 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 LLQIFSPIVGSQRIMQCQFDNAYSSLQCEQGFNL----VFGELLGFTFLKIGQIPVELLG---RQ 104
            |..:.:|::.|...|..:..:.|:....|.|..|    :|||.|   |:.|.....|..|   |:
Human    47 LSTLLAPVIISSMTMLEKLSDTYTCFSTENGNFLYVLHLFGECL---FIAINGDHTESEGDLRRK 108

  Fly   105 MGVAITLTRYCYGANLFAAQAGAMQQEL-------LTQCLDCYETLLW------EEDQTYLLEAM 156
            :.|...|....:|  |.......:::||       ..|..:.:::|||      |::|.:.:||:
Human   109 LYVLKYLFEVHFG--LVTVDGHLIRKELRPPDLAQRVQLWEHFQSLLWTYSRLREQEQCFAVEAL 171

  Fly   157 PRLLINTELKRTVHLTLDATLEHLRQL--------GLPRAHALLLVSNKLVAANSTRQALPLAAA 213
            .| ||:.:|   ..|.::|...|:.|.        |....||.|||.:||:|..|:..|..|..|
Human   172 ER-LIHPQL---CELCIEALERHVIQAVNTSPERGGEEALHAFLLVHSKLLAFYSSHSASSLRPA 232

  Fly   214 DLLFLSLM-------------------SRALQAPKSPSQRA------------------------ 235
            |||.|.|:                   .||..:...|.|:|                        
Human   233 DLLALILLVQDLYPSESTAEDDIQPSPRRARSSQNIPVQQAWSPHSTGPTGGSSAETETDSFSLP 297

  Fly   236 ----------------VAVFLQG------------------------------VSYDVN---SGC 251
                            ..::|:|                              :..|.|   |.|
Human   298 EEYFTPAPSPGDQSSGSTIWLEGGTPPMDALQIAEDTLQTLVPHCPVPSGPRRIFLDANVKESYC 362

  Fly   252 --VPSIVHISRL-HG-NQVLLQVIEYAHMPLT-SCIYDSFFVLQKIVAVQHQGDSDALKPAFENL 311
              ||..::...| .| |.|||.....|.:.|. |.:.|.|.:|:|           .||...|..
Human   363 PLVPHTMYCLPLWQGINLVLLTRSPSAPLALVLSQLMDGFSMLEK-----------KLKEGPEPG 416

  Fly   312 ESFIVQALTA-----LKRYLKQRSETDDLENCTKKFAAK----------WENL-------RKMYT 354
            .|...|.|..     :.:::|.|. ..::::...:|.||          ||.|       |::..
Human   417 ASLRSQPLVGDLRQRMDKFVKNRG-AQEIQSTWLEFKAKAFSKSEPGSSWELLQACGKLKRQLCA 480

  Fly   355 EYFKNFERELLVRIESNLPSFGEELKQIFTLACCDSSSVHELDQLSDTAANVEAKLLEFAEFLAV 419
            .|..||......|...:||.                   |..||:...   :..||.::.:||.|
Human   481 IYRLNFLTTAPSRGGPHLPQ-------------------HLQDQVQRL---MREKLTDWKDFLLV 523

  Fly   420 KATRNISIDAYLEDFPGLVHFMYVNRSRGQMLAPDLRPNQLVP------------KTKLWSMVEI 472
            |:.|||::.:|||||||||||:||:|:.|||:||.|..:|...            |||:||::::
Human   524 KSRRNITMVSYLEDFPGLVHFIYVDRTTGQMVAPSLNCSQKTSSELGKGPLAAFVKTKVWSLIQL 588

  Fly   473 ARNYLKKGQTTVMWKDKAFHYSYFLWFEDMSGGVLSTVVDLQHHFLSTGAASGNGSKSPTEPGAL 537
            ||.||:||.||:::::..|:.|||||||:..|..|..:   :...||..:.       |.  |.|
Human   589 ARRYLQKGYTTLLFQEGDFYCSYFLWFENDMGYKLQMI---EVPVLSDDSV-------PI--GML 641

  Fly   538 TMDYYHDLAELCFPKLSPAK-VRVYELYCIHLGLVTATCAVEHARRL 583
            ..|||..|... :.|..|.: ||.|||..:||.::.....|:.|.:|
Human   642 GGDYYRKLLRY-YSKNRPTEAVRCYELLALHLSVIPTDLLVQQAGQL 687

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HPS1NP_610997.1 Fuz_longin_1 2..143 CDD:465953 24/109 (22%)
Fuzzy 186..289 CDD:477403 41/199 (21%)
Fuz_longin_3 436..587 CDD:465955 59/161 (37%)
HPS1NP_000186.2 Fuz_longin_1 2..159 CDD:465953 31/131 (24%)
[DE]-X(4)-L-L 1 45..51 1/3 (33%)
[DE]-X(4)-L-L 2 147..153 1/5 (20%)
Fuz_longin_2 204..>253 CDD:465954 19/142 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 249..317 21/72 (29%)
[DE]-X(4)-L-L 3 516..522 2/5 (40%)
Fuz_longin_3 540..695 CDD:465955 16/45 (36%)
[DE]-X(4)-L-L 4 644..650
Melanosome targeting signal. /evidence=ECO:0000255 698..700
Blue background indicates that the domain is not in the aligned region.

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