Protein Alignment HPS1 and Hps1

DIOPT Version :10

• Sequence 1: NP_610997.1
• Gene: HPS1 / 36656
• FlyBaseID: FBgn0033973
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_001333632.1
• Gene: Hps1 / 192236
• MGIID: 2177763
• Length: 712
• Species: Mus musculus
• Alignment Length: 766
• Identity: 184/766 - (24%)
• Similarity: 297/766 - (38%)
• Gaps: 238/766 - (31%)

  Fly     1 MNGLIVFNSANDVVYQKLNEPLAQKIRSVATTQGLLQSGGSLDSNI------LLQIFSPIVGSQR 59
            |..::|.....:|::...:|..|:.:|.      .||.....:..:      |..:.:|::.|..
Mouse     1 MKCVLVATEGAEVLFYWTDEEFAESLRL------KLQQSEDEEEELPVLEDQLSTLLAPVIISSM 59

  Fly    60 IMQCQFDNAYSSLQCEQGFNL----VFGELLGFTFLKIGQIPVELLG---RQMGVAITLTRYCYG 117
            .|..:..:.|:....|...:|    :|||.|   |:.|.....|..|   |::.|...|....:|
Mouse    60 TMMEKLSDTYTCFSTENDNHLYVLHLFGEYL---FVAINGDHSESEGDLRRKLCVLKYLFEVHFG 121

  Fly   118 ANLFAAQAGAMQQEL--------------LTQCLDCYETLLWEEDQTYLLEAMPRLL-------- 160
              |.......:::||              ..:.|..| :.|.:.:|::.:||:.||:
Mouse   122 --LVTVDGQLIRKELRPPDLEERARVWKHFQRLLGTY-SYLRDREQSFAVEAVERLIHPQLCEQS 183

  Fly   161 INTELKRTVHLTLDATLEHLRQLGLPRAHALLLVSNKLVAANSTRQALPLAAADLLFLSLMSRAL 225
            |.| |:|.|...::|:.|   :.|....||.|||..||:|..|...|..|..||||.|.|:.:.|
Mouse   184 IET-LERHVVQAINASPE---RGGEEVLHAFLLVHCKLLAFYSGHGASTLRPADLLALILLVQDL 244

  Fly   226 Q----------------------------APKS----PSQRAVA--------------------- 237
            |                            .|||    |.|:|.:
Mouse   245 QPSPGTTEEEEEEEDSDSPQVPEHKGNRRRPKSSQNIPVQQARSQSTSVPTRSSRETDTDSISLP 309

  Fly   238 ------------------VFLQG---------VSYDVNSG------------------------- 250
                              |:|.|         ::.|...|
Mouse   310 EEYFTPAPSPGDQSSGSLVWLDGGTPPSDALQMAEDTPEGLASHSPELPSPRRIFLDANIKENYC 374

  Fly   251 --------CVPSIVHISRLHGNQVLLQVIEYAHMPLTSCIY---DSFFVLQKIVAVQHQGDSDAL 304
                    |:|....|     |.|||  .:....||...:|   |.|.:|:|.:. :.|....||
Mouse   375 PLVPHTMYCLPLWPGI-----NMVLL--TKSPSTPLALILYQLLDGFSLLEKKLK-EGQEAGSAL 431

  Fly   305 KPAFENLESFIVQALTALKRYLKQRSETDDLENCTKKFAAK----------WENLRKMYTEYFKN 359
            :.     :.|:......:.:::|.| ...:::|...:|.:|          ||.|     :....
Mouse   432 RS-----QPFVADLRQKMDKFIKNR-VGQEIQNTWLEFKSKAFSRSEPGSSWELL-----QVCGK 485

  Fly   360 FERELLV--RIESNLPSFGEELKQIFTLACCDSSSVHELDQLSDTAAN-VEAKLLEFAEFLAVKA 421
            .:|:|.|  |:.             |.:........|....|.|.|.. ::.:||::.:||.||:
Mouse   486 LKRQLCVIYRLS-------------FLVTAPSRGGPHLPQHLQDRAQKLMKERLLDWKDFLLVKS 537

  Fly   422 TRNISIDAYLEDFPGLVHFMYVNRSRGQMLAPDLRPNQLVP------------KTKLWSMVEIAR 474
            .||:::.:|||||||||||:||:|:.|||:||.|.||:.:.            |.|:|::|.:||
Mouse   538 RRNVTMVSYLEDFPGLVHFIYVDRTTGQMVAPSLSPNEKMSSELGKGPLAAFVKAKVWALVRLAR 602

  Fly   475 NYLKKGQTTVMWKDKAFHYSYFLWFEDMSGGVLSTVVDLQHHFLSTGAASGNGSKSPTEPGALTM 539
            .||:||.||:::::..|..|||||||:..|..|..:   :...||..:.       |.  |.|..
Mouse   603 RYLQKGCTTLLFQEGDFRCSYFLWFENDMGYKLQMI---EVPVLSDDSV-------PI--GVLGG 655

  Fly   540 DYYHDLAELCFPKLSPAK-VRVYELYCIHLGLVTATCAVEHARRLVATISD 589
            |||..|... :.|..|:: ||.|||..:||.::.....|:.|.:|...:.:
Mouse   656 DYYRKLLRY-YSKSHPSEPVRCYELLTLHLSVIPTDLLVQQASQLARRLGE 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPS1	NP_610997.1	Fuz_longin_1	2..143	CDD:465953	31/167 (19%)
		Fuzzy	186..289	CDD:477403	42/218 (19%)
		Fuz_longin_3	436..587	CDD:465955	59/163 (36%)
Hps1	NP_001333632.1	Fuz_longin_1	2..159	CDD:465953	31/168 (18%)
		[DE]-X(4)-L-L 1	45..51		1/5 (20%)
		Fuz_longin_2	204..>249	CDD:465954	19/44 (43%)
		[DE]-X(4)-L-L 2	528..534		1/5 (20%)
		Fuz_longin_3	552..707	CDD:465955	59/167 (35%)
		[DE]-X(4)-L-L 3	656..662		3/5 (60%)