Protein Alignment HPS1 and Hps1

DIOPT Version :10

• Sequence 1: NP_610997.1
• Gene: HPS1 / 36656
• FlyBaseID: FBgn0033973
• Length: 596
• Species: Drosophila melanogaster
• Sequence 2: NP_414541.2
• Gene: Hps1 / 114638
• RGDID: 69193
• Length: 706
• Species: Rattus norvegicus
• Alignment Length: 766
• Identity: 183/766 - (23%)
• Similarity: 298/766 - (38%)
• Gaps: 244/766 - (31%)

  Fly     1 MNGLIVFNSANDVVY----QKLNEPLAQKIRSVATTQGLLQSGGSLDSNILLQ-----IFSPIVG 56
            |..::|.....:|::    ::..|.|.||.|         ||....:...:|:     :.:|::.
  Rat     1 MRCVLVATEGAEVLFYWTDEEFEENLRQKFR---------QSENEEEELPVLEDQLNTLLAPVII 56

  Fly    57 SQRIMQCQFDNAYSSLQCEQGFNL----VFGELLGFTFLKIGQIPVELLG---RQMGVAITLTRY 114
            |...|..:..:.|:....|.|.:|    :|||.|   |:.|.....|..|   |::.|...|...
  Rat    57 SYMTMLEKLSDTYTCFSTENGDHLYVLHLFGECL---FIAINGDHSENEGDLRRKLCVLKYLFEV 118

  Fly   115 CYGANLFAAQAGAMQQEL--------------LTQCLDCYETLLWEEDQTYLLEAMPRLLINTEL 165
            .:|  |....:..:::||              ..:.|..|..|. |::|::.:||:.| ||:.:|
  Rat   119 HFG--LVTVDSQLIRKELRPPDLEQRAQVWKHFQRLLGTYSRLR-EQEQSFAVEAVER-LIHAQL 179

  Fly   166 KRTVHLTLDATLEHLRQL--------GLPRAHALLLVSNKLVAANSTRQALPLAAADLLFLSLMS 222
               ..|:::....|:.|.        |....||.|||..||:|..|:..|..|..||||.|.|:.
  Rat   180 ---CELSIETLERHVVQAVNSSPERGGEEVLHAFLLVHCKLLAFYSSHVASALRPADLLALILLV 241

  Fly   223 RALQ------------------------------------------------------------- 226
            :.||
  Rat   242 QDLQPSQGTTEEEEDGNDGPQPFPHRRPMSSQNIPVQQPRSQSTSVPTRSSKETDTDSISLPEEY 306

  Fly   227 ---APKSPSQRAVA--VFLQG---------VSYDVNSGCVPSIVHISR-----LHGN-------- 264
               || ||.:::..  |:|.|         ::.|..:|..|....:.|     |..|
  Rat   307 FTPAP-SPGEQSSGSLVWLDGGTPPSDVLQMAEDTFNGLAPHSPELPRPRRIFLDANIKENYCPL 370

  Fly   265 ---------------QVLLQVIEYAHMPLTSCIY---DSFFVLQKIVAVQHQGDSDALKPAFENL 311
                           .|||  .:....||...:|   |.|.:|:|.:. :.|....||:.
  Rat   371 VPHTMYCLPLWPGISMVLL--TKSPSTPLALILYQLLDGFSLLEKKLK-EGQEAGSALRS----- 427

  Fly   312 ESFIVQALTALKRYLKQRSETDDLENCTKKFAAK----------WENL-------RKMYTEYFKN 359
            :.|:......:.:::|.| ...:::|...:|.:|          ||.|       |::...|..|
  Rat   428 QPFVGDLRQKMDKFIKNR-VGQEIQNAWLEFKSKAFSRSEPGSSWELLQICGKLKRQLCAIYRLN 491

  Fly   360 FERELLVRIESNLPSFGEELKQIFTLACCDSSSVHELDQLSDTAAN--VEAKLLEFAEFLAVKAT 422
            |                        ||...|.....|.|...:.|.  ::.:|.::.:||.||:.
  Rat   492 F------------------------LATAPSRGGPHLPQHLQSQAQKLMKERLQDWKDFLLVKSW 532

  Fly   423 RNISIDAYLEDFPGLVHFMYVNRSRGQMLAPDLRPNQLVP------------KTKLWSMVEIARN 475
            ||::|.:|||||||||||:||:|:.|||:||.|.|::.:.            |.|:|:::.:||.
  Rat   533 RNVTIVSYLEDFPGLVHFIYVDRTTGQMVAPSLSPSEKMSSELGKGPLAAFVKAKVWALIRLARR 597

  Fly   476 YLKKGQTTVMWKDKAFHYSYFLWFEDMSGGVLSTVVDLQHHFLSTGAASGNGSKSPTEP-GALTM 539
            ||:||.||:::::..|..|||||||:..|..|..:   :...||..:.          | |.|..
  Rat   598 YLQKGCTTLLFQEGDFRCSYFLWFENDMGYKLQMI---EVPVLSDDSV----------PIGVLGG 649

  Fly   540 DYYHDLAELCFPKLSPAK-VRVYELYCIHLGLVTATCAVEHARRLVATISD 589
            |||..|... :.|..|:: ||.|||..:||.::.....|:.|.:|...:.:
  Rat   650 DYYRKLLRY-YSKSRPSEPVRCYELLTLHLSVIPTDLLVQQANQLARRLGE 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPS1	NP_610997.1	Fuz_longin_1	2..143	CDD:465953	34/170 (20%)
		Fuzzy	186..289	CDD:477403	40/208 (19%)
		Fuz_longin_3	436..587	CDD:465955	57/164 (35%)
Hps1	NP_414541.2	Fuz_longin_1	2..159	CDD:465953	34/170 (20%)
		Fuz_longin_2	204..>269	CDD:465954	19/64 (30%)
		Fuz_longin_3	546..701	CDD:465955	57/168 (34%)