DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ciao1 and CIA1

DIOPT Version :9

Sequence 1:	NP_610996.1	Gene:	Ciao1 / 36655	FlyBaseID:	FBgn0033972	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_010553.3	Gene:	CIA1 / 851860	SGDID:	S000002675	Length:	330	Species:	Saccharomyces cerevisiae

Alignment Length:	343	Identity:	125/343 - (36%)
Similarity:	194/343 - (56%)	Gaps:	27/343 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRLILEHTLQGHKGRIWGVAWHPKGNVFASCGEDKAIRIWSLTGNTWSTKTILSD-GHKRTIRE 64
            |..:.|..:|:.:|.:||...:  ...:.|:...|:.|::.|:..:.::...:|.: .||:.||.
Yeast     1 MASINLIKSLKLYKEKIWSFDF--SQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRS 63

  Fly    65 IRWSPCGQYLASASFDATTAIWSKSSG-----EFECNATLEGHENEVKSVSWSRSGGLLATCSRD 124
            :.|.|....||:.|||:|.:||:|...     |.:..|.:||||||||.|:||..|..|||||||
Yeast    64 VAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRD 128

  Fly   125 KSVWIWEV-AGDDEFECAAVLNPHTQDVKRVVWHPTKDILASASYDNTIKMFAEEPIDNDWDCTA 188
            |||||||. ...:|:||.:||..|:||||.|:|||::.:|||:|||:|::::.:  .|:||:|.|
Yeast   129 KSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKD--YDDDWECVA 191

  Fly   189 TLTSHTSTVWGIDFD-ADGE-RLVSCSDDTTIKIWRAYHPGNTAGVATPDQQTVWKCVCTVSGQH 251
            .|..|..|||..||| .:|. ||.|.|||:|:::|:  :.|:     ..|.|..|.|...:...|
Yeast   192 VLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWK--YMGD-----DEDDQQEWVCEAILPDVH 249

  Fly   252 SRAIYDVSWCKLTGLIATACGDDGIRIFKESSDSKPDEPTFEQITAEEGAHDQDVNSVQWNPVVA 316
            .|.:|:|:| ...||||:. |.||:....|..|.  :...|.:.....|.:  ::|.|:|..:..
Yeast   250 KRQVYNVAW-GFNGLIASV-GADGVLAVYEEVDG--EWKVFAKRALCHGVY--EINVVKWLELNG 308

  Fly   317 GQLISC-SDDGTIKIWKV 333
            ..:::. .|||.:..|.:
Yeast   309 KTILATGGDDGIVNFWSL 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ciao1	NP_610996.1	WD40	6..332	CDD:238121	123/335 (37%)
		WD40	9..>333	CDD:225201	123/333 (37%)
		WD40 repeat	17..57	CDD:293791	7/40 (18%)
		WD40 repeat	63..101	CDD:293791	14/42 (33%)
		WD40 repeat	106..145	CDD:293791	24/39 (62%)
		WD40 repeat	152..191	CDD:293791	17/38 (45%)
		WD40 repeat	197..248	CDD:293791	19/52 (37%)
		WD40 repeat	255..299	CDD:293791	13/43 (30%)
		WD40 repeat	306..331	CDD:293791	6/25 (24%)
CIA1	NP_010553.3	WD40	6..325	CDD:238121	123/335 (37%)
		WD40 repeat	17..54	CDD:293791	7/38 (18%)
		WD40 repeat	63..105	CDD:293791	13/41 (32%)
		WD40 repeat	111..151	CDD:293791	24/39 (62%)
		WD40 repeat	156..194	CDD:293791	18/39 (46%)
		WD40 repeat	201..246	CDD:293791	18/51 (35%)
		WD40 repeat	253..289	CDD:293791	13/39 (33%)
		WD40 repeat	298..326	CDD:293791	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0645
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55850
Inparanoid	1	1.050	216	1.000	Inparanoid score	I791
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54160
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto99373
orthoMCL	1	0.900	-	-		OOG6_102166
Panther	1	1.100	-	-	LDO	PTHR19920
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2069
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790