DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ciao1 and ciao1

DIOPT Version :9

Sequence 1:	NP_610996.1	Gene:	Ciao1 / 36655	FlyBaseID:	FBgn0033972	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_956441.2	Gene:	ciao1 / 795104	ZFINID:	ZDB-GENE-040426-839	Length:	330	Species:	Danio rerio

Alignment Length:	332	Identity:	192/332 - (57%)
Similarity:	241/332 - (72%)	Gaps:	9/332 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GRLILEHTLQGH-KGRIWGVAWHPKGNVFASCGEDKAIRIWSLTGNTWSTKTILSDGHKRTIREI 65
            |.|.|:|.:..| ..|.|.|||:|.|...|:||.|:|||||...|::|..|.:|||||:||:|::
Zfish     3 GALELQHRVSAHPDSRCWYVAWNPAGTTLATCGGDRAIRIWGKEGDSWECKCVLSDGHQRTVRKV 67

  Fly    66 RWSPCGQYLASASFDATTAIWSKSSGEFECNATLEGHENEVKSVSWSRSGGLLATCSRDKSVWIW 130
            .|||||:|||||||||||.||.|:..:|||...|||||||||.|:|:.||.||||||||||||||
Zfish    68 AWSPCGKYLASASFDATTCIWKKTDEDFECLTVLEGHENEVKCVAWAPSGSLLATCSRDKSVWIW 132

  Fly   131 EVAGDDEFECAAVLNPHTQDVKRVVWHPTKDILASASYDNTIKMFAEEPIDNDWDCTATLTSHTS 195
            ||..:||:||.:|:|.||||||.||||||:::||||||||.|.::.||  |:||:|.|||..|.|
Zfish   133 EVDEEDEYECLSVVNSHTQDVKHVVWHPTQELLASASYDNKICIYKEE--DDDWECRATLEGHES 195

  Fly   196 TVWGIDFDADGERLVSCSDDTTIKIWRAYHPGNTAGVATPDQQTVWKCVCTVSGQHSRAIYDVSW 260
            |||.:.||.:|.||.|||||.|:|||:.    :|.|..:.|:.  |||:||:||.|.|.|||::|
Zfish   196 TVWSLTFDPEGRRLASCSDDRTVKIWKE----STTGDGSSDES--WKCICTLSGFHGRTIYDIAW 254

  Fly   261 CKLTGLIATACGDDGIRIFKESSDSKPDEPTFEQITAEEGAHDQDVNSVQWNPVVAGQLISCSDD 325
            |:|||.:||||||||:|:|.|...:.|::|.|........||:||||.|.|||..||.|.:|||:
Zfish   255 CRLTGALATACGDDGVRVFSEDPTADPEQPIFALSAHVPKAHNQDVNCVSWNPKEAGLLATCSDN 319

  Fly   326 GTIKIWK 332
            |...|||
Zfish   320 GEFAIWK 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ciao1	NP_610996.1	WD40	6..332	CDD:238121	188/326 (58%)
		WD40	9..>333	CDD:225201	188/325 (58%)
		WD40 repeat	17..57	CDD:293791	20/39 (51%)
		WD40 repeat	63..101	CDD:293791	24/37 (65%)
		WD40 repeat	106..145	CDD:293791	27/38 (71%)
		WD40 repeat	152..191	CDD:293791	24/38 (63%)
		WD40 repeat	197..248	CDD:293791	24/50 (48%)
		WD40 repeat	255..299	CDD:293791	22/43 (51%)
		WD40 repeat	306..331	CDD:293791	13/24 (54%)
ciao1	NP_956441.2	WD 1	14..53		19/38 (50%)
		WD40 repeat	19..59	CDD:293791	20/39 (51%)
		WD40	22..>329	CDD:225201	185/313 (59%)
		WD40	22..326	CDD:238121	183/311 (59%)
		WD 2	59..98		26/38 (68%)
		WD40 repeat	65..103	CDD:293791	24/37 (65%)
		WD 3	103..142		29/38 (76%)
		WD40 repeat	108..147	CDD:293791	27/38 (71%)
		WD 4	148..187		26/40 (65%)
		WD40 repeat	154..191	CDD:293791	24/38 (63%)
		WD 5	192..231		21/42 (50%)
		WD40 repeat	197..242	CDD:293791	24/50 (48%)
		WD 6	244..283		22/38 (58%)
		WD40 repeat	249..289	CDD:293791	22/39 (56%)
		WD 7	295..330		20/32 (63%)
		WD40 repeat	300..325	CDD:293791	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578370
Domainoid	1	1.000	87	1.000	Domainoid score	I8015
eggNOG	1	0.900	-	-		E1_KOG0645
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55850
Inparanoid	1	1.050	424	1.000	Inparanoid score	I1745
OMA	1	1.010	-	-		QHG54160
OrthoDB	1	1.010	-	-		D365323at33208
OrthoFinder	1	1.000	-	-		FOG0005834
OrthoInspector	1	1.000	-	-		oto39904
orthoMCL	1	0.900	-	-		OOG6_102166
Panther	1	1.100	-	-	LDO	PTHR19920
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2069
SonicParanoid	1	1.000	-	-		X4225
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800