DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ciao1 and SPAC806.02c

DIOPT Version :9

Sequence 1:	NP_610996.1	Gene:	Ciao1 / 36655	FlyBaseID:	FBgn0033972	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_592852.1	Gene:	SPAC806.02c / 2542122	PomBaseID:	SPAC806.02c	Length:	608	Species:	Schizosaccharomyces pombe

Alignment Length:	331	Identity:	129/331 - (38%)
Similarity:	191/331 - (57%)	Gaps:	18/331 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TLQGHKGRIWGVAWHPKGNVFASCGEDKAIRIWSLTGNTWSTKTILSDGHKRTIREIRWSPCGQ- 72
            |:.||.||:|.||.||...:||:..:||::||::  .||::...::...|.|:||.:.|.|..:
pombe   285 TISGHTGRLWSVAAHPMLPLFATSSQDKSVRIYN--SNTYNLVHVIDGFHTRSIRRVAWRPIERP 347

  Fly    73 YLASASFDATTAIWSKSSGEFECNATLEGHENEVKSVSWSRSGGLLATCSRDKSVWIWEVAGDDE 137
            .||.||||:..:|..|...::||.|.|||||||||.::||.:|..||||||||||||||...|||
pombe   348 VLAVASFDSVVSINEKIDDDWECTAALEGHENEVKCIAWSCNGNYLATCSRDKSVWIWEATEDDE 412

  Fly   138 FECAAVLNPHTQDVKRVVWHPTKDILASASYDNTIKMFAEEPIDNDWDCTATLTSHTSTVWGIDF 202
            |:|.|||..||||||.|.||||:|:|.|.||||:|..:.::  .:||..|..|..||:|||.:.|
pombe   413 FDCLAVLQEHTQDVKVVTWHPTEDLLVSGSYDNSICFWRDD--GDDWALTCQLQGHTNTVWALAF 475

  Fly   203 DADGERLVSCSDDTTIKIWRAYHPG------NTAGVATPDQQTVWKCVCTVSGQHSRAIYDVSWC 261
            ..:|..|.|..:|..:.:|......      ::..:..|..|..||...::...|..|:|.:||.
pombe   476 SPNGNTLASADNDGNVFLWIKISSNEDVATIDSTNILRPALQEEWKQQTSLPHIHKGAVYTISWM 540

  Fly   262 KLTGLIATACGDDGIRIFKESSDSKPDEPTFEQITAEEGAHD-QDVNSVQWNPVVAGQLISCSDD 325
            . ...:.:|.||..|.:::.   .|.||..:.....::.||. .::||:::  :...:|:|..||
pombe   541 N-DATLCSAGGDGKIVVYQR---EKHDEALWHVAYEQDHAHGVYEINSLEY--LRDDRLLSGGDD 599

  Fly   326 GTIKIW 331
            |..::|
pombe   600 GECRVW 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ciao1	NP_610996.1	WD40	6..332	CDD:238121	129/331 (39%)
		WD40	9..>333	CDD:225201	129/331 (39%)
		WD40 repeat	17..57	CDD:293791	13/39 (33%)
		WD40 repeat	63..101	CDD:293791	15/38 (39%)
		WD40 repeat	106..145	CDD:293791	26/38 (68%)
		WD40 repeat	152..191	CDD:293791	17/38 (45%)
		WD40 repeat	197..248	CDD:293791	12/56 (21%)
		WD40 repeat	255..299	CDD:293791	10/43 (23%)
		WD40 repeat	306..331	CDD:293791	7/24 (29%)
SPAC806.02c	NP_592852.1	ParA	3..269	CDD:287566
		COG1149	8..246	CDD:224071
		WD40	<283..608	CDD:225201	129/331 (39%)
		WD40	283..606	CDD:238121	129/331 (39%)
		WD40 repeat	293..330	CDD:293791	13/38 (34%)
		WD40 repeat	337..376	CDD:293791	15/38 (39%)
		WD40 repeat	381..420	CDD:293791	26/38 (68%)
		WD40 repeat	427..464	CDD:293791	17/38 (45%)
		WD40 repeat	470..507	CDD:293791	8/36 (22%)
		WD40 repeat	534..575	CDD:293791	10/44 (23%)
		WD40 repeat	582..605	CDD:293791	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	244	1.000	Inparanoid score	I808
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860