Protein Alignment SMC2 and SMC5

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_014608.1
• Gene: SMC5 / 854123
• SGDID: S000005394
• Length: 1093
• Species: Saccharomyces cerevisiae
• Alignment Length: 1230
• Identity: 237/1230 - (19%)
• Similarity: 490/1230 - (39%)
• Gaps: 299/1230 - (24%)

  Fly     5 KLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNV--RASALQDLVY 67
            |:.|..|.:| ..||. ...|....|.|.||||||..:.::|  ||::.....  |:..::|.:
Yeast    44 KIRLQDFVTY-TLTEF-NLSPSLNMIIGPNGSGKSTFVCAVC--LGLAGKPEYIGRSKKVEDFI- 103

  Fly    68 KNGQAGITKATVTIVFDNTNPAQCPQGYEKCRE--ISVTRQVVVGGKNK--FLINGKLVQNKKVQ 128
            |||| .::|..:|:   ..:|......|...|:  |.:|| ::...|.:  :|||...|....|:
Yeast   104 KNGQ-DVSKIEITL---KNSPNVTDIEYIDARDETIKITR-IITRSKRRSDYLINDYQVSESVVK 163

  Fly   129 DFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVR 193
            .....:.:.::|....:.|.::::...:|                      :.|.|:|    .:|
Yeast   164 TLVAQLNIQLDNLCQFLSQERVEEFARLK----------------------SVKLLVE----TIR 202

  Fly   194 ETKVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIR--IHI---SAKYLKQCETLKTVEANE 253
            .    :|..:|..|.:||:.:...|..||   |:||...  :|:   |.|..|..|:|:..:..:
Yeast   203 S----IDASLLDVLDELRELQGNEQSLQK---DLDFKKAKIVHLRQESDKLRKSVESLRDFQNKK 260

  Fly   254 HKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLK 318
            .:||        .|::.|..|:                    :|:.:.:|:..:.....|..:|:
Yeast   261 GEIE--------LHSQLLPYVK--------------------VKDHKEKLNIYKEEYERAKANLR 297

  Fly   319 AAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAV 383
            |    |.:|:|......|.:|:                 :.|.|.|..:..:..:..|::|:..:
Yeast   298 A----ILKDKKPFANTKKTLEN-----------------QVEELTEKCSLKTDEFLKAKEKINEI 341

  Fly   384 SQGLST---------NEN----GEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREG 435
            .:.|:|         |:|    |....||..:|..||.|                    |:.:|.
Yeast   342 FEKLNTIRDEVIKKKNQNEYYRGRTKKLQATIISTKEDF--------------------LRSQEI 386

  Fly   436 ETQTNDAAYVKDKKLHDQLVV---EIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELD 497
            ..||    ::.:|.:.:.:.:   ||.|.|.:::.|      ..::..:.|.::...|.::|:.:
Yeast   387 LAQT----HLPEKSVFEDIDIKRKEIINKEGEIRDL------ISEIDAKANAINHEMRSIQRQAE 441

  Fly   498 RCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKIL 562
            ....|   |...|        |: |::.:...:|::::::.:|:           :......|||
Yeast   442 SKTKS---LTTTD--------KI-GILNQDQDLKEVRDAVLMVR-----------EHPEMKDKIL 483

  Fly   563 QRGNLQRRVTLIPINKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLI 627
            :.          ||..:  .::|.....|....|. .|...|::::|.|.|.      .|...::
Yeast   484 EP----------PIMTV--SAINAQFAAYLAQCVD-YNTSKALTVVDSDSYK------LFANPIL 529

  Fly   628 CKDLIVAKQISYD------PRINCRSVTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEY 686
            .|..:..:::|..      |....|.:..||.:.|   .::|.  .:...:|.:...|..|....
Yeast   530 DKFKVNLRELSSADTTPPVPAETVRDLGFEGYLSD---FITGD--KRVMKMLCQTSKIHTIPVSR 589

  Fly   687 REIDSEIAQVEKQIASIENQALAFNKM---KENLDLRQ-----HELTMCENRLAQTTFQQNQAEI 743
            ||:..  ||::|.|....|..:.|.::   ...:|::|     .::...:..:.||.|.|.....
Yeast   590 RELTP--AQIKKLITPRPNGKILFKRIIHGNRLVDIKQSAYGSKQVFPTDVSIKQTNFYQGSIMS 652

  Fly   744 EEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKGYRER--ELNAATNEIKVTKQRAEKS 806
            .|.:.|:   |.:||:.:.:....::   .::|......|||..  ||.:..::|.....:..:.
Yeast   653 NEQKIRI---ENEIINLKNEYNDRKS---TLDALSNQKSGYRHELSELASKNDDINREAHQLNEI 711

  Fly   807 RANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQ 871
            |..:..|:...|||:.::.:|::.   |:|...:.|.:::                    .:::|
Yeast   712 RKKYTMRKSTIETLREKLDQLKRE---ARKDVSQKIKDID--------------------DQIQQ 753

  Fly   872 AIKEQK---DKLRDQNKEMRN---QLVKKEKMLKENQEIELEV-------KKKENEQKKISSDAK 923
            .:.:|:   .|:....|.::|   :|:..:.:..|.|.:::.:       .::|.:.|....|.|
Yeast   754 LLLKQRHLLSKMASSMKSLKNCQKELISTQILQFEAQNMDVSMNDVIGFFNEREADLKSQYEDKK 818

  Fly   924 EAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKK------------DK 976
            :..|.|........|:.|.::        ||   :|..|..||:|:..|::            ||
Yeast   819 KFVKEMRDTPEFQSWMREIRS--------YD---QDTKEKLNKVAEKYEEEGNFNLSFVQDVLDK 872

  Fly   977 MERTLNM-----NAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEE---QDQLNKAAT 1033
            :|..:.|     :|:.:||:.....:|.|   :.|....:.::.|..|:.|:.   :.:|:...:
Yeast   873 LESEIAMVNHDESAVTILDQVTAELRELE---HTVPQQSKDLETIKAKLKEDHAVLEPKLDDIVS 934

  Fly  1034 EVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNG---IWKESLGELSGGQKSLVALSL 1095
            :::..|:.:|:::......:|.. ..:.....:||.|.|..   :.|......|||::::..:..
Yeast   935 KISARFARLFNNVGSAGAVRLEK-PKDYAEWKIEIMVKFRDNAPLKKLDSHTQSGGERAVSTVLY 998

  Fly  1096 VLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHF----TNSQFLIV-SLKDGLFNH 1150
            ::|:.:|:.||..::||::..:|..:.:.:...:.::.    |:..|||. .|..||..|
Yeast   999 MIALQEFTSAPFRVVDEINQGMDSRNERIVHKAMVENACAENTSQYFLITPKLLTGLHYH 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	237/1230 (19%)
SMC5	NP_014608.1	P-loop containing Nucleoside Triphosphate Hydrolases	40..>198	CDD:476819	42/185 (23%)
		SMC_N	42..1048	CDD:481474	232/1218 (19%)
		Smc5_CC_C	739..811	CDD:467855	10/91 (11%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<956..1072	CDD:476819	23/104 (22%)