Protein Alignment SMC2 and SMC4

DIOPT Version :9

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_013187.1
• Gene: SMC4 / 850775
• SGDID: S000004076
• Length: 1418
• Species: Saccharomyces cerevisiae
• Alignment Length: 1370
• Identity: 291/1370 - (21%)
• Similarity: 592/1370 - (43%)
• Gaps: 305/1370 - (22%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            :::.:|||:.||||..:..:..|...|:|:.|.|||||||::||:.||.|. ....:|...|.||
Yeast   154 LFINELVLENFKSYAGKQVVGPFHTSFSAVVGPNGSGKSNVIDSMLFVFGF-RANKMRQDRLSDL 217

  Fly    66 VYKNG--------------QAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFL 116
            ::|:.              |..|.:::.|...|...|.           :.:||:......:|:.
Yeast   218 IHKSEAFPSLQSCSVAVHFQYVIDESSGTSRIDEEKPG-----------LIITRKAFKNNSSKYY 271

  Fly   117 INGKLVQNKKVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKE-------VLSMVEEAAGTSQY 174
            ||.|.....:|.....:..:::::..|||:||:::.:..||||.       :|..:|:..||:.|
Yeast   272 INEKESSYTEVTKLLKNEGIDLDHKRFLILQGEVENIAQMKPKAEKESDDGLLEYLEDIIGTANY 336

  Fly   175 KTKRDATKTLIEKKETKVRE-TKVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDF--------- 229
                   |.|||::..::.. .:|.|::|...::|.  :|:::.:..::..  ::|
Yeast   337 -------KPLIEERMGQIENLNEVCLEKENRFEIVD--REKNSLESGKETA--LEFLEKEKQLTL 390

  Fly   230 ----LIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDA 290
                |.:..:.....|...||:.:.::...:||.    |....::|.:|:.|:...||::.:|.:
Yeast   391 LRSKLFQFKLLQSNSKLASTLEKISSSNKDLEDE----KMKFQESLKKVDEIKAQRKEIKDRISS 451

  Fly   291 EMGGSIKNLETQLSAKRALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKV 355
               .|.|. :|.:..:|.||.|.....:..:..:.:.||    |.|.::..:.::::.|..:.::
Yeast   452 ---CSSKE-KTLVLERRELEGTRVSLEERTKNLVSKMEK----AEKTLKSTKHSISEAENMLEEL 508

  Fly   356 QGEFESLKEADARD-SKAYEDAQKKLEAVSQGL---STNENGEASTLQEQLIVAKEQFSEAQTTI 416
            :|: ::..|.:.:| ::..|..:..|:.:...|   :.|.:.|....:::|.....|..|.::.|
Yeast   509 RGQ-QTEHETEIKDLTQLLEKERSILDDIKLSLKDKTKNISAEIIRHEKELEPWDLQLQEKESQI 572

  Fly   417 KTSEIELRHTRGVLKQREGETQTNDAAY---VKDKKLHDQLVVE-IKNLERQLQSLDYEGGHFEK 477
            :.:|.||    .:|::.:.:.:.|....   :..||.|.|.:.: |.:|:::|.||..|....||
Yeast   573 QLAESEL----SLLEETQAKLKKNVETLEEKILAKKTHKQELQDLILDLKKKLNSLKDERSQGEK 633

  Fly   478 LKQRRNDLHMRKRDLKRELD----RCNASRYDLQYQDPEPNF--------DRRKVRGLVGKLFQV 530
               .....|::.:::::.|:    |...:|..|.....:...        ...::.|..|:|..:
Yeast   634 ---NFTSAHLKLKEMQKVLNAHRQRAMEARSSLSKAQNKSKVLTALSRLQKSGRINGFHGRLGDL 695

  Fly   531 KDMQNSM-ALVQTAGGSLYSYVTD---------DDVTSKKI----------LQRGNLQRRVTLIP 575
            ..:.:|. ..:.||...|...|.|         |.:...|:          |::.|||      |
Yeast   696 GVIDDSFDVAISTACPRLDDVVVDTVECAQHCIDYLRKNKLGYARFILLDRLRQFNLQ------P 754

  Fly   576 INKIQSGSLNRNVVEYAQNKVGAENVQWAMSLI-----DYDRYYEPVMKFCFGGTLICKDLIVAK 635
            |:.                   .|||.....|:     .:...:..|::    .||:.::|..|.
Yeast   755 IST-------------------PENVPRLFDLVKPKNPKFSNAFYSVLR----DTLVAQNLKQAN 796

  Fly   636 QISYDPRINCRSVTLEGDVVDPHGTVSGGAAPKGANVLEELHAI--KQIEKEYREIDSEIAQVEK 698
            .::|..: ..|.||::|.::|..||:|||    |.:|.:.|..:  .|.:|.......|:.::|:
Yeast   797 NVAYGKK-RFRVVTVDGKLIDISGTMSGG----GNHVAKGLMKLGTNQSDKVDDYTPEEVDKIER 856

  Fly   699 QIASIENQ----ALAFNKMKENL-DLRQH--------------------ELTMCENRLAQT---- 734
            :::..||.    :...::|:|.| .||.|                    |||:.|.::.:.
Yeast   857 ELSERENNFRVASDTVHEMEEELKKLRDHEPDLESQISKAEMEADSLASELTLAEQQVKEAEMAY 921

  Fly   735 ----------------------TFQQNQAEIEEMRERVKTLEQQIID--------SREKQKTSQA 769
                                  .:...|:|.:..:|::|.|:.:|:.        ...|.::...
Yeast   922 VKAVSDKAQLNVVMKNLERLRGEYNDLQSETKTKKEKIKGLQDEIMKIGGIKLQMQNSKVESVCQ 986

  Fly   770 KIVDIEAKLADAKG-----------------YRERELNAATNEIKVTKQRAEKSRANWKKREQEF 817
            |:..:.|||...|.                 ..||::..:::|:||.:::.:.::....:.:...
Yeast   987 KLDILVAKLKKVKSASKKSGGDVVKFQKLLQNSERDVELSSDELKVIEEQLKHTKLALAENDTNM 1051

  Fly   818 -ETLQLEITELQKSIETAKKQHQEMIDNLEKFKA-------ELDALKVNSSSAASEVTELEQAIK 874
             |||.|:: ||::..|..|:|.::|.:::.:||:       :|:.|....:...||:|:.|:.:.
Yeast  1052 NETLNLKV-ELKEQSEQLKEQMEDMEESINEFKSIEIEMKNKLEKLNSLLTYIKSEITQQEKGLN 1115

  Fly   875 EQKDKLRDQNKEM----RNQLVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAK 935
            |.  .:||....:    .|::...::.:|.|||::.|.:..|.:.:   |:.|:|
Yeast  1116 EL--SIRDVTHTLGMLDDNKMDSVKEDVKNNQELDQEYRSCETQDE---SEIKDA---------- 1165

  Fly   936 YPWIPEEKNC-----FGMKNTRYDYSKEDPHEAGNKL---------AKMQEKKDKMERTLNMNAI 986
                  |.:|     ..:..|..:.|:..|..:.::|         :|:.|....:|.| |:: |
Yeast  1166 ------ETSCDNYHPMNIDETSDEVSRGIPRLSEDELRELDVELIESKINELSYYVEET-NVD-I 1222

  Fly   987 MVLDREEENFKETERRR---NIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLP 1048
            .||:.......|.:||:   |.....::::|:.:..:.::..|:.......::.....::..:..
Yeast  1223 GVLEEYARRLAEFKRRKLDLNNAVQKRDEVKEQLGILKKKRFDEFMAGFNIISMTLKEMYQMITM 1287

  Fly  1049 GAEAKLNPVHTNGCLTGLEIKVGFNGI-----WKESLGELSGGQKSLVALSLVLAMLKFSPAPLY 1108
            |..|:|..|.:   |......|.|:.:     |: ::..||||:|:|.:|:||.|:.|:.|.|||
Yeast  1288 GGNAELELVDS---LDPFSEGVTFSVMPPKKSWR-NITNLSGGEKTLSSLALVFALHKYKPTPLY 1348

  Fly  1109 ILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVLFRTLFEEGVSTITRQVSRQ 1173
            ::||:|||||..:...:.:.:|:...|:||:::||::.:|..|..|        |....|....:
Yeast  1349 VMDEIDAALDFRNVSIVANYIKERTKNAQFIVISLRNNMFELAQQL--------VGVYKRDNRTK 1405

  Fly  1174 ATTNK 1178
            :||.|
Yeast  1406 STTIK 1410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	287/1358 (21%)
		ABC_SMC2_euk	1..>170	CDD:213240	51/189 (27%)
		SMC_hinge	520..637	CDD:214944	26/141 (18%)
		V_Alix_like	690..933	CDD:187408	62/330 (19%)
		P-loop_NTPase	<1073..1167	CDD:304359	33/98 (34%)
SMC4	NP_013187.1	Smc	154..1418	CDD:224117	291/1370 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810