Protein Alignment SMC2 and SMC1

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_116647.1
• Gene: SMC1 / 850540
• SGDID: S000001886
• Length: 1225
• Species: Saccharomyces cerevisiae
• Alignment Length: 1343
• Identity: 294/1343 - (21%)
• Similarity: 572/1343 - (42%)
• Gaps: 299/1343 - (22%)

  Fly     6 LVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNG 70
            |.|..||||...|::...:..||:|.|.|||||||::|:|.||||:.: .::|::.|:||:|:
Yeast     7 LELSNFKSYRGVTKVGFGESNFTSIIGPNGSGKSNMMDAISFVLGVRS-NHLRSNILKDLIYR-- 68

  Fly    71 QAGITKATVTIVFDNTNPAQC-PQG------YEKCRE-ISVTRQVVVGGKNKFLINGKLVQNKKV 127
              |:.....:..:||...|.. ||.      |:|..: :.:.|.:...|...:.|:||.|..|..
Yeast    69 --GVLNDENSDDYDNEGAASSNPQSAYVKAFYQKGNKLVELMRIISRNGDTSYKIDGKTVSYKDY 131

  Fly   128 QDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKV 192
            ..|..:..:.:...|||:.||.::|:....|.|:..|.||.:|:.|||.:.:..|..|||.....
Yeast   132 SIFLENENILIKAKNFLVFQGDVEQIAAQSPVELSRMFEEVSGSIQYKKEYEELKEKIEKLSKSA 196

  Fly   193 RETKVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCE------------T 245
            .|:        :....::..|...|:|            .|:.:.:|.||.:            .
Yeast   197 TES--------IKNRRRIHGELKTYKE------------GINKNEEYRKQLDKKNELQKFQALWQ 241

  Fly   246 LKTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALE 310
            |..:|..:.::.|:::      |.| :|:.|::..:....:.:.......:|            |
Yeast   242 LYHLEQQKEELTDKLS------ALN-SEISSLKGKINNEMKSLQRSKSSFVK------------E 287

  Fly   311 ATATGSLKAAQGTIQQDEKKI-----------RMASKNIEDDERALAKKEADMAKVQ---GEFES 361
            :......|:....|.:|::|:           :.|.|.|...|:.:...:.|:.:.:   ..||:
Yeast   288 SAVISKQKSKLDYIFKDKEKLVSDLRLIKVPQQAAGKRISHIEKRIESLQKDLQRQKTYVERFET 352

  Fly   362 LKEADARDSKAYEDAQKKLEAVSQGLSTNENG--------------EASTLQEQLIVAKEQFSEA 412
            ..:...|..:|:|:..|:..........|||.              ..|.|:|::.|......|.
Yeast   353 QLKVVTRSKEAFEEEIKQSARNYDKFKLNENDLKTYNCLHEKYLTEGGSILEEKIAVLNNDKREI 417

  Fly   413 QTTIKTSEIELRHTRGVLKQRE--------GE---TQTNDAAYVKDKK--LHDQLVVEIKNLERQ 464
            |     .|:|..:.|..:.:|.        ||   ||.||.....::|  ||.:.:.|:|.|:..
Yeast   418 Q-----EELERFNKRADISKRRITEELSITGEKLDTQLNDLRVSLNEKNALHTERLHELKKLQSD 477

  Fly   465 LQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNAS-RYDLQYQDPEPNFDRRK-----VRGL 523
            ::|.:          .:..||:.:.|:...::|..:|: |..::.:....|....|     |:||
Yeast   478 IESAN----------NQEYDLNFKLRETLVKIDDLSANQRETMKERKLRENIAMLKRFFPGVKGL 532

  Fly   524 VGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRVT--LIPINKIQSGSLNR 586
            |..|...|..:..:|:....|.:..|.:.::...:::.:.....||..|  .||::.|::.....
Yeast   533 VHDLCHPKKEKYGLAVSTILGKNFDSVIVENLTVAQECIAFLKKQRAGTASFIPLDTIETELPTL 597

  Fly   587 NVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLE 651
            ::.:       :::...:::.|||:..||..|::..|.::||..|.:||.:.:...|..:.||:|
Yeast   598 SLPD-------SQDYILSINAIDYEPEYEKAMQYVCGDSIICNTLNIAKDLKWKKGIRGKLVTIE 655

  Fly   652 GDVVDPHGTVSGGAAPKGAN-----VLEELHAIK-----QIEK----------EYREIDSEIAQV 696
            |.::...|.::||.:....|     ..:.|.::|     ||::          ..||:::.::.:
Yeast   656 GALIHKAGLMTGGISGDANNRWDKEEYQSLMSLKDKLLIQIDELSNGQRSNSIRAREVENSVSLL 720

  Fly   697 EKQIASIENQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSR 761
            ...||::..|.   .:.|.:||         ||||             |::.....:|::|
Yeast   721 NSDIANLRTQV---TQQKRSLD---------ENRL-------------EIKYHNDLIEKEI---- 756

  Fly   762 EKQKTSQAKIVDIEAKLADAKGYRE---RELNAATNEI------KV---TKQRAEKSRANWKKRE 814
                  |.||.:::.||.|.:..::   :|..|..|.|      |:   .|:....|....:::.
Yeast   757 ------QPKITELKKKLDDLENTKDNLVKEKEALQNNIFKEFTSKIGFTIKEYENHSGELMRQQS 815

  Fly   815 QEFETLQLEITELQKSIE-------TAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQA 872
            :|.:.||.:|..::..::       |.::::::...:||..:.|:.:|:....:...::..:|..
Yeast   816 KELQQLQKQILTVENKLQFETDRLSTTQRRYEKAQKDLENAQVEMKSLEEQEYAIEMKIGSIESK 880

  Fly   873 IKEQKDKLRDQNKEMRNQLVKKEKMLKENQEI------ELEVKKKENEQKK-------------- 917
            ::|.|:.|    .|::.:.|.|:..|..:::|      .|:|.|:|.:..|
Yeast   881 LEEHKNHL----DELQKKFVTKQSELNSSEDILEDMNSNLQVLKRERDGIKEDIEKFDLERVTAL 941

  Fly   918 ----------------------ISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDP 960
                                  |||...||.....:::..|..:|:          :|   ||:.
Yeast   942 KNCKISNINIPISSETTIDDLPISSTDNEAITISNSIDINYKGLPK----------KY---KENN 993

  Fly   961 HEAGNKLAKMQEKKDKMERTLN---MNAIMVLDREEENFKETERRRNIVAMDKEKI----KKII- 1017
            .::..|  ::::|..::|..||   .||     |..|.:.|.|.|..::..:.|::    |||:
Yeast   994 TDSARK--ELEQKIHEVEEILNELQPNA-----RALERYDEAEGRFEVINNETEQLKAEEKKILN 1051

  Fly  1018 --VKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWK--- 1077
              :|:.::.::...|....|:.:...|:..|.....:.:.....|..||..:....||...|
Yeast  1052 QFLKIKKKRKELFEKTFDYVSDHLDAIYRELTKNPNSNVELAGGNASLTIEDEDEPFNAGIKYHA 1116

  Fly  1078 -------ESLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFT- 1134
                   :.:..||||:|::.||:|:.|:..:.|:|.::|||||||||:::.|.|.:.:::|..
Yeast  1117 TPPLKRFKDMEYLSGGEKTVAALALLFAINSYQPSPFFVLDEVDAALDITNVQRIAAYIRRHRNP 1181

  Fly  1135 NSQFLIVSLKDGLFNHANVL---FRTLFEEGVSTITRQVSRQA 1174
            :.||:::|||:.:|..::.|   :|...|.....||..:|..|
Yeast  1182 DLQFIVISLKNTMFEKSDALVGVYRQQQENSSKIITLDLSNYA 1224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	290/1329 (22%)
SMC1	NP_116647.1	SMC_N	4..1209	CDD:426784	289/1326 (22%)