Protein Alignment SMC2 and SMC3

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001190492.1
• Gene: SMC3 / 834917
• AraportID: AT5G48600
• Length: 1244
• Species: Arabidopsis thaliana
• Alignment Length: 1295
• Identity: 300/1295 - (23%)
• Similarity: 549/1295 - (42%)
• Gaps: 243/1295 - (18%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            :|:|:||:..||||.....:..|...|:|:.|.|||||||::|::.||.| ...:.:|.:.:.:|
plant    24 LYIKELVMRNFKSYAGEQRVGPFHKSFSAVVGPNGSGKSNVIDAMLFVFG-KRAKQMRLNKVSEL 87

  Fly    66 VYKN-GQAGITKATVTIVFD----------NTNPAQCPQGYEKCREISVTRQVVVGGKNKFLING 119
            ::.: ....:..|.|::.|:          .|.|..         :..:||.......:|:.||.
plant    88 IHNSTNHQNLDSAGVSVQFEEIIDLENGLYETVPGS---------DFMITRVAFRDNSSKYYINE 143

  Fly   120 KLVQNKKVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKE-------VLSMVEEAAGTSQYKTK 177
            :.....:|........::::|..|||:||:::|:..||||.       .|..:|:..||::|..|
plant   144 RSSNFTEVTKKLKGKGVDLDNNRFLILQGEVEQISLMKPKAQGPHDEGFLEYLEDIIGTNKYVEK 208

  Fly   178 RD----ATKTLIEKKETKVRETKV----------LLDEE---VLPKLVKLR-QERSAYQEYQ--- 221
            .|    ..:||.|.:...|:..|:          |.||.   :|.:|..|: ||::....|:
plant   209 IDELNKQLETLNESRSGVVQMVKLAEKERDNLEGLKDEAETYMLKELSHLKWQEKATKMAYEDTV 273

  Fly   222 -KICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQ 285
             ||....|.|..:..|.|    .|.:|..|:||     .:...::.|.|:....|.::|.::..:
plant   274 AKITEQRDSLQNLENSLK----DERVKMDESNE-----ELKKFESVHEKHKKRQEVLDNELRACK 329

  Fly   286 QQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEA 350
            ::........:|:.|.....|:        .:|..:..:::|..||...:|..||....:.|.:.
plant   330 EKFKEFERQDVKHREDLKHVKQ--------KIKKLEDKLEKDSSKIGDMTKESEDSSNLIPKLQE 386

  Fly   351 DMAKVQ-------GEFESLKEADARDSKAYEDAQKKLEA----------VSQGLSTNENGEASTL 398
            ::.|:|       .:.|.:|.....:::.|.....|:.|          |.:|.....:.|:..|
plant   387 NIPKLQKVLLDEEKKLEEIKAIAKVETEGYRSELTKIRAELEPWEKDLIVHRGKLDVASSESELL 451

  Fly   399 QEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLH--DQLVVEIKNL 461
            .::...|.:.|::||..:  |:|..|      |:.:....|:..|.:|.||..  :...||.::|
plant   452 SKKHEAALKAFTDAQKQL--SDISTR------KKEKAAATTSWKADIKKKKQEAIEARKVEEESL 508

  Fly   462 ERQLQSLDYEGGHFEKLKQRRNDLHMRK--RDLKRELDRCNASRYDLQYQDPEPNFDRRKVRGLV 524
            :.|...:..|....||:.:.::.::..|  .::.:.:.|..               :..::.|:.
plant   509 KEQETLVPQEQAAREKVAELKSAMNSEKSQNEVLKAVLRAK---------------ENNQIEGIY 558

  Fly   525 GKLFQVK--DMQNSMALVQTAGGSLYSYVTDDDVTSK-----KILQRGNLQRRVTLIPINKIQSG 582
            |::..:.  |.:..:|:.....|..|..|   :.||.     ::|::|||.....:|
plant   559 GRMGDLGAIDAKYDVAISTACAGLDYIVV---ETTSSAQACVELLRKGNLGFATFMI-------- 612

  Fly   583 SLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCF----GGTLICKDLIVAKQISY-DPR 642
             |.:......:.|...:..:....|.|..|..:..||..|    |.|::.|||..|.:|:| ..|
plant   613 -LEKQTDHIHKLKEKVKTPEDVPRLFDLVRVKDERMKLAFYAALGNTVVAKDLDQATRIAYGGNR 676

  Fly   643 INCRSVTLEGDVVDPHGTVSGGAA-PKG-----------------ANVLEELHAIKQI-----EK 684
            ...|.|.|:|.:.:..||:|||.. .:|                 ||...||..|..:     ||
plant   677 EFRRVVALDGALFEKSGTMSGGGGKARGGRMGTSIRATGVSGEAVANAENELSKIVDMLNNIREK 741

  Fly   685 ------EYREIDSEIAQVEKQIASIENQALAFNKMKENLDLRQHELTMCENRLA--QTTFQQNQA 741
                  :||..::|::.:|.::|..:.:..:.|.          |....|.:||  :...|....
plant   742 VGNAVRQYRAAENEVSGLEMELAKSQREIESLNS----------EHNYLEKQLASLEAASQPKTD 796

  Fly   742 EIEEMRERVKTL--EQQIIDSREK-QKTSQAKIVDIEAKLADAKGYRERELNAATNEIK--VTKQ 801
            ||:.::|..|.:  |::.|::.|| .|..:.|.::::..:.:|.|.:.:...|...:|:  :.|.
plant   797 EIDRLKELKKIISKEEKEIENLEKGSKQLKDKALELQTNIENAGGEKLKGQKAKVEKIQTDIDKN 861

  Fly   802 RAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEV 866
            ..|.:|.|     .:.||.|..|.:|.|.||.|.::.    :.||..|..|.....:.:..|.|:
plant   862 NTEINRCN-----VQIETNQKLIKKLTKGIEEATREK----ERLEGEKENLHVTFKDITQKAFEI 917

  Fly   867 TE----LEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIELEV---KKKENEQKKISSDAKE 924
            .|    .:|.|.|.||.|.....:..|.....:::.....:.|.:|   |||.||   :....|.
plant   918 QETYKKTQQLIDEHKDVLTGAKSDYENLKKSVDELKASRVDAEFKVQDMKKKYNE---LEMREKG 979

  Fly   925 AKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVL 989
            .||::..|:..:     .|:   |:..:.|....|..:|......:.|..| ::|.|.|.|::
plant   980 YKKKLNDLQIAF-----TKH---MEQIQKDLVDPDKLQATLMDNNLNEACD-LKRALEMVALL-- 1033

  Fly   990 DREEENFKETERRRNIVAMDKEKIKKIIVKMDE-----EEQDQLNKAATE--------------- 1034
               |...||.....:.:|..:.|::....::||     :|:|...|...|
plant  1034 ---EAQLKELNPNLDSIAEYRSKVELYNGRVDELNSVTQERDDTRKQYDELRKRRLDEFMAGFNT 1095

  Fly  1035 VNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFN-----GIWKESLGELSGGQKSLVALS 1094
            ::.....::..:..|.:|:|..|.:   |......|.|:     ..|| ::..||||:|:|.:|:
plant  1096 ISLKLKEMYQMITLGGDAELELVDS---LDPFSEGVVFSVRPPKKSWK-NIANLSGGEKTLSSLA 1156

  Fly  1095 LVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVL 1154
            ||.|:..:.|.|||::||:|||||..:...:|..:|....::||:|:||::.:|..|:.|
plant  1157 LVFALHHYKPTPLYVMDEIDAALDFKNVSIVGHYVKDRTKDAQFIIISLRNNMFELADRL 1216

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	300/1294 (23%)
SMC3	NP_001190492.1	SMC_N	25..1228	CDD:426784	300/1294 (23%)