Protein Alignment SMC2 and SMC6A

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_196383.1
• Gene: SMC6A / 830659
• AraportID: AT5G07660
• Length: 1058
• Species: Arabidopsis thaliana
• Alignment Length: 1264
• Identity: 258/1264 - (20%)
• Similarity: 476/1264 - (37%)
• Gaps: 369/1264 - (29%)

  Fly     3 VKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVY 67
            :.::.|:.|..:. ..||| |......|||.||||||.||.::|...|.......||:.|:|.:
plant    23 ILRIRLENFMCHS-NLEIE-FGDWVNFITGQNGSGKSAILTALCVAFGCRARGTQRAATLKDFI- 84

  Fly    68 KNGQAGITKATVTIVFDNT-NPAQCPQGYEKC----REISVTRQVVVGGKNKFLINGKLVQNKK- 126
               :.|.:.|.|.:...|. ..|..|:.|...    |.||.:..:.|...::    |:.:.::|
plant    85 ---KTGCSYALVYVELKNQGEDAFKPEIYGDTLIIERRISDSTSLTVLKDHQ----GRKISSRKE 142

  Fly   127 -VQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKE- 189
             :::......::|.||..::.|.|.::.|:             :|..:.|.|.....||:::.:
plant   143 ELRELVEHYNIDVENPCVIMSQDKSREFLH-------------SGNDKDKFKFFYKATLLQQVDD 194

  Fly   190 ------TKVRETKVLLDEEVLPKLVK-LRQERSAYQEYQKICRDIDFLIR--IHISAKYL----- 240
                  ||:.....||||  :.|.:| :.:|.:...|..|....::.:.:  :|:..|..
plant   195 ILQSIGTKLNSANALLDE--MEKTIKPIEKEINELLEKIKNMEHVEEITQQVLHLKKKLAWSWVY 257

  Fly   241 ---KQCETLKTVEANEH--KIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLE 300
               :|.:     |.||.  |.::|:..|:....:.|.||||:..|:.|.:.|:..       .::
plant   258 DVDRQLK-----EQNEKIVKFKERVPTCQNKIDRKLGEVESLRVSLTEKKAQVAC-------LID 310

  Fly   301 TQLSAKRALEATATGSLKAAQ-------------GTIQQDEKKIRMASKNIED-DERALAKKEAD 351
            ...:.||.||.......|||:             ..||:.:.::|...:.||| :|..:...:.:
plant   311 ESTAMKRELECLRQSMKKAAREKIALEEEYHHKCSNIQKIKDRVRRLERQIEDINEMTIRSTQVE 375

  Fly   352 MAKVQGEFESL----KEADARDSKAYEDAQKKLEAVSQGLSTNENGEASTLQEQLIVAKEQFSEA 412
            .::::|:...|    ::|::..|...|:....:|..|.|                  .||:
plant   376 QSEIEGKLNQLTVEVEKAESLVSSLKEEENMVMEKASAG------------------GKEK---- 418

  Fly   413 QTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLH----------DQLVVEIKNLER---- 463
                       .|...:::..| :.|.|..|::.|.|.|          |:::..::.:||
plant   419 -----------EHIEEMIRDHE-KKQRNMNAHINDLKKHQTNKVTAFGGDKVINLLRAIERHHRR 471

  Fly   464 -QLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKVRGLVGKL 527
             ::..:...|.|...:                     |.:|:            ...|...:|.|
plant   472 FKMPPIGPIGAHVTLI---------------------NGNRW------------ASAVEQALGNL 503

  Fly   528 ---FQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKIL----QRGNLQRRVTLIPINKIQSGSLN 585
               |.|.|.::.:||......:.|:        :.||:    .|..|.     ||
plant   504 LNAFIVTDHKDLVALRDCGKEAKYN--------NLKIIIYDFSRPRLD-----IP---------- 545

  Fly   586 RNVVEYAQNK-----VGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRI-N 644
            |:::...::.     :.:||......|:|..         |....::.::..|.|.|:::.|: :
plant   546 RHMIPQTEHPTILSVLHSENTTVLNVLVDVS---------CVERHVLAENYEVGKIIAFERRLSH 601

  Fly   645 CRSV-TLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQAL 708
            .:.| |::|..:...|.|.....|:.                 |......|..:.||..:|.:|
plant   602 LKDVFTIDGYRMFSRGPVQTTLPPRP-----------------RRPTRLCASFDDQIKDLEIEA- 648

  Fly   709 AFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVD 773
                     ...|.|:..|..:..:.  :.|...:|....|:|           ||:|...|  |
plant   649 ---------SREQSEIQECRGQKREA--EMNLEGLESTMRRLK-----------KQRTQLEK--D 689

  Fly   774 IEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQH 838
            :..|        |.|:....|.:....:.:..|..|         .|.|||.:.||.||..:...
plant   690 LTRK--------ELEMQDLKNSVASETKASPTSSVN---------ELHLEIMKFQKEIEEKESLL 737

  Fly   839 QEMIDNLEKFKAELDALKVNSS------SAASEVTELEQA---IKEQKDKLRDQNKEMRN-QLVK 893
            :::.|:|:  :|||.|.::.:|      ||..|:..||:|   :||::|:|.....|..: :.:.
plant   738 EKLQDSLK--EAELKANELKASYENLYESAKGEIEALEKAEDELKEKEDELHSAETEKNHYEDIM 800

  Fly   894 KEKMLKENQEI-----ELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRY 953
            |:|:|.|.::.     |||:|::|: .||.|....|::     ::|..||
plant   801 KDKVLPEIKQAETIYKELEMKRQES-NKKASIICPESE-----IKALGPW--------------- 844

  Fly   954 DYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKET---------------ERRR 1003
              ....|.:...::.|:..:               |.||.||:.|:               .::|
plant   845 --DGPTPLQLSAQINKINHR---------------LKRENENYSESIDDLRIMHGEKEQKIGKKR 892

  Fly  1004 NIVAMDKEKIKKIIVKMD------EEEQDQLNKAAT-EVNTNF--SGIFSSLLPGAEAKLNPVHT 1059
            ......:||:|.....:|      :..:|.|.:..| :.|.:.  .||..::....|.|
plant   893 KTYKSCREKLKVCKDAVDSRWNKLQRNKDLLKRELTWQFNHHLGKKGISGNIRVSYEDK------ 951

  Fly  1060 NGCLTGLEIKV---GFNGIWKESLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALD--- 1118
               ...:|:|:   ..|...:::.| ||||::|...|...||:...:.||:..:||.|..:|
plant   952 ---TLSIEVKMPQDATNSAVRDTRG-LSGGERSFSTLCFTLALQNMTEAPIRAMDEFDVFMDAVS 1012

  Fly  1119 --MSHTQNIGSMLKQHFTNSQFLIVSLKD 1145
              :|....|...|||   .||::.::..|
plant  1013 RKISLDTLIDFALKQ---GSQWMFITPHD 1038

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	258/1264 (20%)
SMC6A	NP_196383.1	P-loop containing Nucleoside Triphosphate Hydrolases	23..>177	CDD:476819	43/176 (24%)
		SMC_prok_B	<196..928	CDD:274008	179/943 (19%)
		P-loop containing Nucleoside Triphosphate Hydrolases	<962..1058	CDD:476819	24/81 (30%)