DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and TTN8

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_001319748.1	Gene:	TTN8 / 824632	AraportID:	AT3G54670	Length:	1218	Species:	Arabidopsis thaliana

Alignment Length:	1299	Identity:	287/1299 - (22%)
Similarity:	543/1299 - (41%)	Gaps:	263/1299 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVY 67
            :.:|.::.|||| :..::.|...:||||.|.|||||||::|:|.||||:...| :|.|.|:||:|
plant    11 ILQLEMENFKSY-KGHQLVGPFKDFTAIIGPNGSGKSNLMDAISFVLGVRTGQ-LRGSQLKDLIY 73

  Fly    68 -----KNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKV 127
                 ...|.| .||.|.:|:      |...|.    |:..||.:...|.:::.|:.::|...:.
plant    74 AFDDRDKEQRG-RKAFVRLVY------QMDDGV----ELRFTRSITSAGGSEYRIDNRVVNLDEY 127

  Fly   128 QDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKV 192
            .....|:.:.|...|||:.||.::.:.:..|||:..::||.:|:.:.|.:.:.    :|:|:...
plant   128 NGKLRSLGILVKARNFLVFQGDVESIASKNPKELTGLLEEISGSEELKKEYEG----LEEKKASA 188

  Fly   193 RETKVLL--------DEEVLPKLVK---------------LRQERSAYQEY------QKICRDID 228
            .|...|:        :|:.|.|..|               |::||..:|.|      :|...|:|
plant   189 EEKAALIYQKKKTIGNEKKLKKAQKEEAEKHLRLQEELKALKRERFLWQLYNIENDIEKANEDVD 253

  Fly   229 FLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQID---- 289
                        .:....|.|.....|.|......|...||.|.|:...|..:.|...::.
plant   254 ------------SEKSNRKDVMRELEKFEREAGKRKVEQAKYLKEIAQREKKIAEKSSKLGKIQP 306

  Fly   290 ---------AEMGGSIKNLETQLSAKRALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDERAL 345
                     |.:...|:.....:..::..:...:..::..|.:|::..||:.:.:|..:|....|
plant   307 ELLRFKEEIARIKAKIETNRKDVDKRKKEKGKHSKEIEQMQKSIKELNKKMELFNKKRQDSSGKL 371

  Fly   346 ------------AKKEADM--AKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLSTNENGEAS 396
                        .|:||.|  .|::.|.|.|:    |..:...:|.:.||...|.|...:|
plant   372 PMLDSQLQDYFRLKEEAGMKTIKLRDEHEVLE----RQRRTDLEALRNLEENYQQLINRKN---- 428

  Fly   397 TLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQLVVEIKNL 461
            .|.||:    ::|.:.|..|:||..:.::....||.   |.:.....:|..::...:|...|..|
plant   429 DLDEQI----KRFKDRQGEIETSSSKYKNETTSLKT---ELRALQEKHVNAREASAKLKTRIAEL 486

  Fly   462 ERQLQSLD---YEGGH-------FEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFD 516
            |.||..|.   ||...       .|.||:....:|.|..||.|.    |..:|:|
plant   487 EDQLSDLTAERYENERDSRLTQAVESLKRLFQGVHGRMTDLCRP----NRKKYNL---------- 537

  Fly   517 RRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQR--RVTLIPINKI 579
                                 |:....|..:.:.|.:|:.|.|..::....||  .:|.||:..:
plant   538 ---------------------AVTVAMGRFMDAVVVEDENTGKDCIKYLKEQRLPPMTFIPLQSV 581

  Fly   580 QSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRIN 644
            :.    :.|.|..:|..|...:  ...:|.:|...|..:.:..|.||:|.:|..||.:|:... .
plant   582 RV----KQVFERLRNLGGTAKL--VFDVIQFDPELEKAVLYAVGNTLVCDELEEAKVLSWSGE-R 639

  Fly   645 CRSVTLEGDVVDPHGTVSGGAAP--------------KG--------ANVLEELHAIKQIEKEYR 687
            .:.||::|.::...||::||.:.              :|        ...||.:.:|::::.:..
plant   640 FKVVTVDGILLTKAGTMTGGTSGGMEAKSNKWDDKKIEGLKKNKEDFEQQLENIGSIREMQMKES 704

  Fly   688 EIDSEIAQVEKQI--ASIENQALAFNKMKENL-DLRQHELTMCE--NRL------AQTTFQQNQA 741
            ||..:|:.:||:|  |.||.:::     |:.| .|.|.|..:.|  :|:      |:|...:.:.
plant   705 EISGKISGLEKKIQYAEIEKKSI-----KDKLPQLEQEERNIIEEIDRIKPELSKARTEVDKRKT 764

  Fly   742 EIEEMRERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNE----IKVTKQR 802
            |:.::.:|:    .:|:|...|..:....:.:|..       |.|.:|..|..|    ::::.|.
plant   765 EMNKLEKRM----NEIVDRIYKDFSQSVGVPNIRV-------YEETQLKTAEKEAEERLELSNQL 818

  Fly   803 A--------EKSR---ANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALK 856
            |        |::|   :..:|.|....:|:.::..:||::...|:...::.:.:..:|.|::..|
plant   819 AKLKYQLEYEQNRDVGSRIRKIESSISSLETDLEGIQKTMSERKETAVKITNEINNWKKEMEECK 883

  Fly   857 VNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIELEVKKKENEQKKISSD 921
            ..|.....|:.:.::...:....:...|:::.::..:.|:::.:.||| .|..:.|:....:.||
plant   884 QKSEEYEKEILDWKKQASQATTSITKLNRQIHSKETQIEQLISQKQEI-TEKCELEHITLPVLSD 947

  Fly   922 AKEAKKRMEALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGNKL-----AKMQEKKDKMERTL 981
            |      ||..::..|.       |........|.:|....|..|:     .|::.|..::|||.
plant   948 A------MEEDDSDGPQ-------FDFSELGRAYLQERRPSAREKVEAEFRQKIESKTSEIERTA 999

  Fly   982 -NMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSS 1045
             |:.|:...:..:|..|:..:.......:::::......:.::..:...:|...:.:|...|:..
plant  1000 PNLRALDQYEAIQEKEKQVSQEFEAARKEEKQVADAFNTVKQKRYELFMEAFNHIASNIDKIYKQ 1064

  Fly  1046 LLP------GAEAKLNPVHTNG-CLTGLEIKVGFNGIWKESLGELSGGQKSLVALSLVLAMLKFS 1103
            |..      |..|.||..:.:. .|.|::............:.:||||:|::.||:|:.::..:.
plant  1065 LTKSNTHPLGGTAYLNLENEDDPFLHGIKYTTMPPTKRFRDMEQLSGGEKTVAALALLFSIHSYR 1129

  Fly  1104 PAPLYILDEVDAALDMSHTQNIGSMLKQHFTNS-------------QFLIVSLKDGLFNHANVL 1154
            |:|.:||||||||||..:...:...::.....:             |.:::||||..::.|..|
plant  1130 PSPFFILDEVDAALDNLNVAKVAKFIRSKSCQAARDNQDAEDGNGFQSIVISLKDSFYDKAEAL 1193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	287/1299 (22%)
		ABC_SMC2_euk	1..>170	CDD:213240	57/171 (33%)
		SMC_hinge	520..637	CDD:214944	25/118 (21%)
		V_Alix_like	690..933	CDD:187408	54/268 (20%)
		P-loop_NTPase	<1073..1167	CDD:304359	27/95 (28%)
TTN8	NP_001319748.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810