DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and ATSMC2

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_001325474.1	Gene:	ATSMC2 / 823900	AraportID:	AT3G47460	Length:	1174	Species:	Arabidopsis thaliana

Alignment Length:	1200	Identity:	459/1200 - (38%)
Similarity:	718/1200 - (59%)	Gaps:	52/1200 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            |::|::.|:|||||..||.:.||||.|.|||||||||||||||||||||||:|||.|||:.||:|
plant     1 MHIKEICLEGFKSYATRTVVPGFDPHFNAITGLNGSGKSNILDSICFVLGITNLQQVRAANLQEL 65

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDF 130
            |||.||||||:|||::.|||:...:.|.|:|...||:||||:|||||||:||||||.|..:||:.
plant    66 VYKQGQAGITRATVSVTFDNSERNRSPLGHEDHSEITVTRQIVVGGKNKYLINGKLAQPNQVQNL 130

  Fly   131 FCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRET 195
            |.|:|||||||:||||||:|.:||||||.|:|||:||||||..|:.|::|....:|||:|||.|.
plant   131 FHSVQLNVNNPHFLIMQGRITKVLNMKPMEILSMLEEAAGTRMYENKKEAALKTLEKKQTKVDEI 195

  Fly   196 KVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIED-- 258
            ..||::::||.|.|||:|:|.|.::.....::|.|.|..::.:|: |.|.::  :.:.|.:|:
plant   196 NKLLEKDILPALEKLRREKSQYMQWANGNAELDRLKRFCVAFEYV-QAEKIR--DNSIHVVEEMK 257

  Fly   259 -RIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQG 322
             ::........|...|:..:|..:|.:.|..:|.|||.:|.|..::.:...........|...:.
plant   258 IKMTGIDEQTDKTQGEISELEKQIKALTQAREASMGGEVKALSDKVDSLSNEVTRELSKLTNMED 322

  Fly   323 TIQQDEKKIRMASKNIED-----DERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEA 382
            |:|.:||.......||||     :|||.|..:.|    :|..| ||:.....|...|:.:::.:.
plant   323 TLQGEEKNAEKMVHNIEDLKKSVEERASALNKCD----EGAAE-LKQKFQEFSTTLEECEREHQG 382

  Fly   383 VSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQT-NDAAYVK 446
            :..|.|:.:  |...|::||..||.....|:|.:|....::.|....||:::.:..: .|.|...
plant   383 ILAGKSSGD--EEKCLEDQLRDAKISVGTAETELKQLNTKISHCEKELKEKKSQLMSKQDEAVAV 445

  Fly   447 DKKLHDQLVVEIKNLERQLQSLDYEGGHFEKL-KQRRNDLHMRKRDLKRELDRCNASRYDLQ--Y 508
            :.:| |....::::::|...||.|:.|..|.| |.|.::|.:..| ||.::...:|...::|  |
plant   446 ENEL-DARKNDVESVKRAFDSLPYKEGQMEALEKDRESELEIGHR-LKDKVHELSAQLANVQFTY 508

  Fly   509 QDPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRVTL 573
            :||..||||.||:|:|.||.:|.|..:..||..||||.|::.:.|.:.|.|::||:|:|:||||:
plant   509 RDPVKNFDRSKVKGVVAKLIKVNDRSSMTALEVTAGGKLFNVIVDTEDTGKQLLQKGDLRRRVTI 573

  Fly   574 IPINKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQIS 638
            ||:|||||..:...|.:.....||..|.:.|:||:.|....:..|::.||.|.:||....||:::
plant   574 IPLNKIQSHLVPPRVQQATVKLVGKGNAELALSLVGYSEELKNAMEYVFGSTFVCKTTDAAKEVA 638

  Fly   639 YDPRINCRSVTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASI 703
            ::..|...||||||||..|.|.::||:...|.::|.:||.:.:.|.::|.....::::|..|..:
plant   639 FNREIRTPSVTLEGDVFQPSGLLTGGSRKGGGDLLRQLHDLAEAETKFRAHQKSLSEIEANIKEL 703

  Fly   704 ENQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQ 768
            :.....|..||..|:|:.:::::...|..|....:....::::.|.|:.:..||.:.....|:..
plant   704 QPLQTKFTDMKAQLELKMYDMSLFLKRAEQNEHHKLGDAVKKLEEEVEEMRSQIKEKEGLYKSCA 768

  Fly   769 AKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIET 833
            ..:..:|..:.|....||..|......||..|.|.:.|..:.|..|...|.|.:|        :.
plant   769 DTVSTLEKSIKDHDKNREGRLKDLEKNIKTLKARIQASSKDLKGHENVRERLVME--------QE 825

  Fly   834 AKKQHQEMIDNLEKFKAELDALKVNSSSAASEV-----------TELEQAIKEQK---DKLRDQN 884
            |..|.|..:      |::|.:|:...|:.||:|           .:.:|::.|.|   .|:::.:
plant   826 AVTQEQSYL------KSQLTSLRTQISTLASDVGNQRAKVDAIQKDHDQSLSELKLIHAKMKECD 884

  Fly   885 KEMRNQLVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMK 949
            .::...:.::||.|::..:::|:.||.|||..::..:.|....:::.|..|:.||..||..||..
plant   885 TQISGSIAEQEKCLQKISDMKLDRKKLENEVTRMEMEHKNCSVKVDKLVEKHTWITSEKRLFGNG 949

  Fly   950 NTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIK 1014
            .|.||:...|||:|..:|.::|..:..:|:.:|.....:.::.|:.:.....::||:..||.|||
plant   950 GTDYDFESRDPHKAREELERLQTDQSSLEKRVNKKVTAMFEKAEDEYNALMTKKNIIETDKSKIK 1014

  Fly  1015 KIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKES 1079
            |:|.::||::::.|.....:||.:|..|||:||||..:||.|......|.|||::|.|..:||:|
plant  1015 KVIEELDEKKKETLKVTWVKVNQDFGSIFSTLLPGTMSKLEPPEGGTFLDGLEVRVAFGDVWKQS 1079

  Fly  1080 LGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLK 1144
            |.||||||:||:||||:||:|.|.|||:|||||||||||:|||||||.|:|.||.:|||::||||
plant  1080 LSELSGGQRSLLALSLILALLLFKPAPIYILDEVDAALDLSHTQNIGRMIKSHFPHSQFIVVSLK 1144

  Fly  1145 DGLFNHANVLFRTLFEEGVSTITRQVSRQA 1174
            :|:|::|:|||||.|.:||||:.|.|::|:
plant  1145 EGMFSNADVLFRTKFVDGVSTVQRTVTKQS 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	456/1192 (38%)
		ABC_SMC2_euk	1..>170	CDD:213240	116/168 (69%)
		SMC_hinge	520..637	CDD:214944	48/116 (41%)
		V_Alix_like	690..933	CDD:187408	53/256 (21%)
		P-loop_NTPase	<1073..1167	CDD:304359	65/93 (70%)
ATSMC2	NP_001325474.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	787	1.000	Domainoid score	I7
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4705
Inparanoid	1	1.050	811	1.000	Inparanoid score	I82
OMA	1	1.010	-	-		QHG54206
OrthoDB	1	1.010	-	-		D119789at2759
OrthoFinder	1	1.000	-	-		FOG0003760
OrthoInspector	1	1.000	-	-		otm2670
orthoMCL	1	0.900	-	-		OOG6_101492
Panther	1	1.100	-	-	O	PTHR43941
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3124
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840