DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and smc1b

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	XP_009296271.1	Gene:	smc1b / 797354	ZFINID:	ZDB-GENE-091217-1	Length:	1235	Species:	Danio rerio

Alignment Length:	1328	Identity:	307/1328 - (23%)
Similarity:	560/1328 - (42%)	Gaps:	291/1328 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLV 66
            ::|:|.::.|||:..:..|..| ..|..|.|.|||||||::|::.||:| ....|:|....:||:
Zfish     3 FLKQLDVENFKSWRGKQTIGPF-KRFNCIIGTNGSGKSNVMDALGFVMG-ERAANLRVKHTRDLI 65

  Fly    67 Y--KNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQD 129
            :  ..|....|.|:||:::...|.          .|::.:|: :.|..:::|:|||.|...|...
Zfish    66 HGAHIGNPVSTFASVTMIYCGDND----------EEMTFSRR-ISGESSEYLVNGKHVTLAKYTG 119

  Fly   130 FFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTS----QYKTK-------RDATKT 183
            ....|.:.|...|.|:.||.::.:..|..||...|.|..:|:.    :|.||       ::.|:.
Zfish   120 ELQKIGIVVKAKNCLVYQGAVESIAMMNAKERTKMFERISGSGDLNIEYFTKLAVLQKAKEDTQF 184

  Fly   184 LIEKKETKVRETKVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCE---T 245
            ...:|:....|.|            ::.::::..|.||.:..|             |::|:   |
Zfish   185 HFNRKKAATAEKK------------QVFKDKTEAQRYQSLVDD-------------LRECKLQLT 224

  Fly   246 LKTVEANEHKIEDR---IANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQL-SAK 306
            |..:..||..|:.:   :.:.:|..|:....:::.|.:|| .|::....:...::.||.:: |.:
Zfish   225 LFQLFHNEKSIDAQSASLGDMQAAAAQQKISLDAWEQTVK-TQKKEHGRLNRELQQLEKEIRSQE 288

  Fly   307 RALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESL--------- 362
            :.|.......:||...| ...|:|::.|.::::.::...|||..::.:::.|...|
Zfish   289 QILNQQRPQYIKAKVNT-SHHEQKVQEAHRSLQKNQNLQAKKGQELEELKRELTELERAWKTSER 352

  Fly   363 --KEADARDSKAYEDAQKKLE--------AVSQGLSTNENGEASTLQEQLIVAKEQF-----SEA 412
              :|.:||.....:..:.:||        |...|...|::.|....:.:....|.||     ||.
Zfish   353 QMEEEEARRGAGVQLQESQLERYKELKELARRNGAILNQSAEKLHWEVKADREKLQFDLRRKSEI 417

  Fly   413 QTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQLVVEI-KNLERQLQSLDYEGGH-F 475
            |..||.|:..|.......::.|....|......:.::..:||..|: |.|.| ::.::.|... .
Zfish   418 QGNIKHSQTHLEDISRRAEKLEEYVNTTTQTLEEQRQQEEQLSEELAKGLVR-MEEVNVELAQVL 481

  Fly   476 EKLKQRRNDLHMRKRDLKRE--LDRCNASRYDLQYQDPEPNFDR---------RKVRGLVGKLFQ 529
            .||:..|.|....:|..||:  |:       .|:...|:..:.|         :|.:..|.|:|.
Zfish   482 TKLQNARLDSQENRRQQKRDEVLE-------SLRRLYPDTVYGRLVELCQPIHKKYQLAVTKVFG 539

  Fly   530 VKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRV---TLIPINKIQSGSLNRNVVEY 591
                :|..|:|.|:     :||..|.:...|       :.|.   |.:||:.|....||..:.|.
Zfish   540 ----KNMNAIVVTS-----AYVAHDCIRYLK-------EERAEPETFLPIDYIDVPILNERLREV 588

  Fly   592 AQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRSVTLEGDVVD 656
            ...|:..:.||.:.:.....|    |:::..|.:|:|:.|..|::|::|.....::|.|:|.:..
Zfish   589 QGAKMVVDVVQCSQNAPQLKR----VIQYVCGNSLVCETLKDARRIAFDGPERLQTVALDGTLFR 649

  Fly   657 PHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNKMKENLDLRQ 721
            ..|.:|||::.           :.:..:.:.|.|....:.||...|.|.:||...|.|| :||:|
Zfish   650 KSGVISGGSSD-----------LSKKARRWEEKDMNKLKEEKDKLSSEMRALMKLKRKE-VDLKQ 702

  Fly   722 HELTMCENR------------LAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQAKIVDI 774
            .......|:            :.:.:....|.||.::|..:..||.||     :.:|...::.|.
Zfish   703 IRAQSQGNQTRLKYANTELDSIRKKSIPAAQIEISKLRSELSNLEAQI-----EIQTGNLELKDS 762

  Fly   775 EAKLADAKGYRERELNAA--TNEIKVT------------KQRAEKSRANWKKREQ------EFET 819
            |.|....|.::..:|..|  ..||.|.            :|..||.|..::.::.      |:|.
Zfish   763 EMKAVKDKIHQMEDLVFADFCAEIGVANIREYEQDYLRLQQELEKKRLQFESQQTRLSTQLEYEQ 827

  Fly   820 LQLE-ITELQKSIETAKKQHQEMI-------DNL----EKFKAELDALKVNSSSAASEVTELEQA 872
            .||| :.:|.|.||...::.:.:|       ||:    |:.::.|  ||:|:..  ||.|.|...
Zfish   828 AQLEKLVKLMKKIEETIEKEKNIIISLKEGEDNILIAVEQTQSNL--LKLNNQH--SEKTHLVNN 888

  Fly   873 IKEQKDK----LRDQNK---EMRNQLVKKE------KMLKEN-------------------QEIE 905
            .|.:.||    |:::||   :::.|.:..:      ::.|.|                   .:|.
Zfish   889 AKTELDKALTGLQERNKVLMKLQKQTISTDAALEHLRLTKHNLLLTCKIDGLPLTLISGALDDIS 953

  Fly   906 LEVKKKENEQKKISS-DAKEAKKRM----EALEAKYPWIPEEKNCFGMKNTRYDYSKEDPHEAGN 965
             |::.:..|.:.:|: |..|.:.:|    .||:.....:.||.....|
Zfish   954 -EIQVQTEESQSVSTLDIFEREAQMVFDFSALDNSLKMLTEESEVEAM----------------- 1000

  Fly   966 KLAKMQEKKDKME------RTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEE 1024
             |.|::|....:|      |..|:.|:..:...:::::|        .:|...|..|..|...:|
Zfish  1001 -LEKLKEGVSSLESMIMMSRAPNLKALEKIREVKDSYRE--------VLDAFDISTITTKKRNQE 1056

  Fly  1025 QDQL--------NKAATEVNTNFSGIFSSLLPGAEAKL-----NPVHTNGCLTGLEIKVGFNGIW 1076
            .:|:        ::....|:.....|:..|...|.|:.     ||  ....|.|:.......|..
Zfish  1057 FEQVKAKRFHLFSQCFEHVSVVIDQIYKKLCRNASAQAILSAENP--NEPYLDGINYNCVAPGKR 1119

  Fly  1077 KESLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGS------MLKQHFTN 1135
            ..::..||||:|::.||:||.|:..|.|||.::|||||||||   ..|||.      |:.:.  :
Zfish  1120 FMAMDNLSGGEKAIAALALVFAIHSFRPAPFFVLDEVDAALD---NTNIGKVTGFFRMMSRE--S 1179

  Fly  1136 SQFLIVSLKDGLFNHANVLF--RTLFEE 1161
            .|.:::|||:..::.|:.|.  .::|:|
Zfish  1180 CQIIVISLKEEFYSRADALLGVYSMFDE 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	307/1328 (23%)
		ABC_SMC2_euk	1..>170	CDD:213240	51/169 (30%)
		SMC_hinge	520..637	CDD:214944	29/119 (24%)
		V_Alix_like	690..933	CDD:187408	74/323 (23%)
		P-loop_NTPase	<1073..1167	CDD:304359	36/97 (37%)
smc1b	XP_009296271.1	Smc	3..1221	CDD:224117	307/1328 (23%)
		ABC_SMC1_euk	4..>148	CDD:213242	47/156 (30%)
		SMC_hinge	515..630	CDD:214944	31/134 (23%)
		P-loop_NTPase	<1115..1218	CDD:304359	36/98 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910