DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and Smc4

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_598547.1	Gene:	Smc4 / 70099	MGIID:	1917349	Length:	1286	Species:	Mus musculus

Alignment Length:	1294	Identity:	285/1294 - (22%)
Similarity:	538/1294 - (41%)	Gaps:	265/1294 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            :.:..:|...||||.....:..|...|:.|.|.|||||||::||:.||.|. ..|.:|:..|..|
Mouse    80 LMITHIVNQNFKSYAGEKVLGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGY-RAQKIRSKKLSVL 143

  Fly    66 VYKNGQ-AGITKATVTIVFDNTNPAQCPQGYEKC--REISVTRQVVVGGKNKFLINGKLVQNKKV 127
            ::.:.: ..|...||.:.|......: ...||..  ....|:|.......:.:.|:||....|.|
Mouse   144 IHNSDEHKDIQSCTVEVHFQKIIDKE-GDDYEVLPNSNFYVSRTAYRDSTSVYHISGKKKTFKDV 207

  Fly   128 QDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKV 192
            .:...|..:::::..|||:||:::|:..||||   ...|...|..:|.........|.|..:...
Mouse   208 GNLLRSHGIDLDHNRFLILQGEVEQIAMMKPK---GQTEHDEGMLEYLEDIIGCGRLNEPIKVLC 269

  Fly   193 RETKVLLDE--EVLPKLVKLRQERSAYQEYQKICRDIDFLI--------RIHISAKYLKQCET-L 246
            |..::|.:.  |.|.::..:.:|:.|.:..:.|.  |:||.        :.||...|:...:. :
Mouse   270 RRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIA--IEFLTLENEMFKKKNHICQYYIYDLQNRI 332

  Fly   247 KTVEANEHKI-EDR---------IANCKATHAKNLA--EVESIENSV-------KEMQQQIDAE- 291
            ..:...:.|| ||.         ::|  ...|||.|  :||...|.|       ||...|:|.|
Mouse   333 AEITTQKEKIHEDTKEITEKSNVLSN--EMKAKNSAVKDVEKKLNKVTKFIEQNKEKFTQLDLED 395

  Fly   292 ---------MGGSIKNLETQL---------------SAKRALEATAT--GSLKAAQGTIQQDEKK 330
                     .....|.||.||               .:|..:..|.|  .||:..:   :::|||
Mouse   396 VQVREKLKHATSKAKKLEKQLQKDKEKVEELKSVPAKSKTVINETTTRNNSLEKER---EKEEKK 457

  Fly   331 IRMASKNIEDDERALAK-KEADMAKVQGEFESLKEADARDSKAYEDAQKKLE--------AVSQG 386
            ::....:::.:.:.|.| ||....::.|..:|:.||.::    .|.||.:|:        ||||
Mouse   458 LKEVMDSLKQETQGLQKEKEIQEKELMGFNKSVNEARSK----MEVAQSELDIYLSRHNTAVSQ- 517

  Fly   387 LSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLH 451
                    .|..:|.||.|.|...|.:..||....:|..|:..||::|.|.|          ||
Mouse   518 --------LSKAKEALITASETLKERKAAIKDINTKLPQTQQELKEKEKELQ----------KL- 563

  Fly   452 DQLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFD 516
            .|..:.:|:|...|         |:|:::.::.|.|         :|......|...|:.:..
Mouse   564 TQEEINLKSLVHDL---------FQKVEEAKSSLAM---------NRSRGKVLDAIIQEKKSG-- 608

  Fly   517 RRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKK----ILQRGNLQRRVTLIPIN 577
              ::.|:.|:|..:..:.....:..::......|:..|.:.:.:    .|::.|: ...|.|.::
Mouse   609 --RIPGIYGRLGDLGAIDEKYDIAISSCCHALDYIVVDSIDTAQECVNFLKKHNI-GIATFIGLD 670

  Fly   578 KIQSGSLNRNVVEYAQN--------KVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVA 634
            |:...:...:.::..:|        ||..|.::.|        :|     |....||:..:|..|
Mouse   671 KMTVWAKKMSKIQTPENTPRLFDLVKVKNEEIRQA--------FY-----FALRDTLVANNLDQA 722

  Fly   635 KQISYDPRINCRSVTLEGDVVDPHGTVSGGAAP-----KGANVLEELHAIKQIEKEYREIDSEIA 694
            .:::|......|.|||:|.:::..||:|||.:.     .|::|::|: :::::.|    ::|::.
Mouse   723 TRVAYQRDRRWRVVTLQGQIIEQSGTMSGGGSKVMRGRMGSSVIDEI-SVEEVNK----MESQLE 782

  Fly   695 QVEKQIASIENQALAFNKMKENLDLRQHELTMCENRLAQ----TTFQQNQAEIEEMRE------- 748
            :..||...|:.|.:            |||..:.:.|.::    .|.::..|.|:.:.|
Mouse   783 RHSKQAMQIQEQKV------------QHEEAVVKLRHSERDMRNTLEKFAASIQGLSEQEEYLCV 835

  Fly   749 RVKTLEQQIIDS---REKQKTSQAKIVDIEAK---LADAKGYRERELNAATNEIKVTKQRAEKSR 807
            ::|.||..::.:   |::||..:..:...:.:   :|:..|..|.|:....|.|.....|..|::
Mouse   836 QIKELEANVLTTAPDRKQQKLLEENVSVFKKEYDAVAEKAGKVEAEIKRLHNTIIDINNRKLKAQ 900

  Fly   808 ANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQA 872
                                |..::|..||..|....:.|.:..:.....|...|...|...|:.
Mouse   901 --------------------QNKLDTINKQLDECASAITKAQVAIKTADRNLKKAQDSVCRTEKE 945

  Fly   873 IKEQKDKLRDQNKEMRNQLVKKEKML--------------KENQEIELEVKKKENEQKKISSDAK 923
            ||:.:.::.|...|::|...|.|:::              ||::.:..|:|..:..:..:..||.
Mouse   946 IKDTEKEINDLKTELKNIEDKAEEVINNTKTAETSLPEIQKEHRNLLQELKVIQENEHALQKDAL 1010

  Fly   924 EAKKRMEALEA---------KYPW---------IPEEKNCFGMKNTRYDYSKED------PHEAG 964
            ..|.::|.::.         || |         .|.|.|   ...|....|:|:      |....
Mouse  1011 SIKLKLEQIDGHISEHNSKIKY-WQKEISKIKLHPVEDN---PVETVAVLSQEELEAIKNPESIT 1071

  Fly   965 NKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLN 1029
            |::|.::.:..:|:.  |:.||....::|:.:.:.....:.:..:::..::....:.::..::..
Mouse  1072 NEIALLEAQCREMKP--NLGAIAEYKKKEDLYLQRVAELDKITSERDNFRQAYEDLRKQRLNEFM 1134

  Fly  1030 KAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFN-----GIWKESLGELSGGQKS 1089
            .....:.......:..|..|.:|:|..|.:   |......:.|:     ..||: :..||||:|:
Mouse  1135 AGFYVITNKLKENYQMLTLGGDAELELVDS---LDPFSEGIMFSVRPPKKSWKK-IFNLSGGEKT 1195

  Fly  1090 LVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLF 1148
            |.:|:||.|:..:.|.|||.:||:|||||..:...:...:.:...|:||:|:||::.:|
Mouse  1196 LSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMF 1254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	285/1294 (22%)
		ABC_SMC2_euk	1..>170	CDD:213240	50/171 (29%)
		SMC_hinge	520..637	CDD:214944	21/128 (16%)
		V_Alix_like	690..933	CDD:187408	52/273 (19%)
		P-loop_NTPase	<1073..1167	CDD:304359	30/81 (37%)
Smc4	NP_598547.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
Smc4	NP_598547.1	SMC_N	81..1272	CDD:308206	285/1293 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810