DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and Rad50

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_071582.2	Gene:	Rad50 / 64012	RGDID:	621542	Length:	1312	Species:	Rattus norvegicus

Alignment Length:	1427	Identity:	277/1427 - (19%)
Similarity:	518/1427 - (36%)	Gaps:	449/1427 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VKKLVLDGFKSYG---RRTEIEGFDPEFTAITGLNGSGKSNILDSICFVL--------------- 49
            ::|:.:.|.:|:|   :..:|..|....|.:.|.||:||:.|::.:.::.
  Rat     4 IEKMSILGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTKGNTFVH 68

  Fly    50 --GISNLQNVRASALQDLVYKNGQAGITK--------------ATVTIVFDNTNPAQCPQGYEKC 98
              .::...:|||.........||:..:.:              .|:..|.......:......||
  Rat    69 DPKVAQETDVRAQIRLQFRDVNGEMVLVQRSMLCSQKSKKTEFKTLEGVITRIKHGEKVSLSSKC 133

  Fly    99 REISVTRQVV-VGGKNKFLINGKLVQNKKVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVL 162
            .||.  |::: ..|.:|.::|..:         ||    :..:.|:.:.:||   .|..|..|:.
  Rat   134 AEID--REMISCLGVSKSVLNNVI---------FC----HQEDSNWPLSEGK---ALKQKFDEIF 180

  Fly   163 SMVEEAAGTSQYKTKRDATKTLIEKKETKVRETKVLLDEEVLPKLVKLRQERSAYQEYQKICRDI 227
            |       .::|....|..:.:.:.:..||:|.:.        :|..|||.:      :|.|.
  Rat   181 S-------ATRYIKALDTLRQVRQTQGQKVKECQT--------ELKYLRQNK------EKACE-- 222

  Fly   228 DFLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKATHAKNLAEVESIENSVKEM---QQQID 289
               ||..|::|..:...:.:.|:|.|:::|. :.|.......||:::..::|.:|.:   ::|::
  Rat   223 ---IRDQITSKEAQLASSREIVKAYENELEP-LKNRLKEIEHNLSKIMRLDNEIKALDSRKKQME 283

  Fly   290 AEMGGSIKNLETQLSAKRALEAT---ATGSLKAAQGTIQQDEKKIRMASKNIE---DDERALAKK 348
            .:      |.|.:...::..:.|   ........|.|:::.|:::....:.:|   .:.|.|.::
  Rat   284 KD------NSELEQKMEKVFQGTDEQLNDLYHNHQRTVREKERRLVDCQRELEKLSKEARLLNQE 342

  Fly   349 EADMAKVQGEFESLKEAD-------ARDS------------------------KAY-----EDAQ 377
            .|::...||..:  .:||       ||||                        |.:     |..:
  Rat   343 RAELLVEQGRLQ--LQADRHQEHIRARDSLIQSLAAHLELDGFERGPFSERQIKNFHELVRERQE 405

  Fly   378 KKLEAVSQGLSTNENGEASTLQEQLIVAKEQFS------EAQTTIKT-SEIELRHTRGVLKQREG 435
            ::.:..||.||...:.|| ..|.|:...:::.|      |.:|.|.| .:.|||:.|..|:|.||
  Rat   406 REAKTASQLLSDLTDKEA-LKQRQMDEMRDKKSGLGRMIELKTEILTKKQTELRNVRNELQQLEG 469

  Fly   436 ETQTNDAAYVKDKKLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCN 500
            .:         |:.|  :|..|:...||:|...: :....|.||....:|...|.||.|.|
  Rat   470 SS---------DRIL--ELDQELTKAERELSKAE-KNSSIETLKAEILNLQSEKADLDRNL---- 518

  Fly   501 ASRYDLQYQDPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRG 565
                                    .||.|..:..|.....:|....|....||.|...:||..|.
  Rat   519 ------------------------RKLDQEMEQLNHHTTTRTQMEMLTKDKTDKDEQIRKIKSRH 559

  Fly   566 N---------------------------LQRRVTLIPINK-IQSGSLNRNVVEYAQNKVGAENVQ 602
            :                           .|.|..|..:|| :.|...|:|.:.....|...:...
  Rat   560 SDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASAEQNKNHINNELKKKEEQLSS 624

  Fly   603 WAMSLI----------DYDRYYEPVMK------FCFGGTLICKDLIVAKQISYDPRINC----RS 647
            :...|.          |.||..|.:.|      ...|.|.:....|.  |::.:.:..|    |.
  Rat   625 YEDKLFDVCGSQDFESDLDRLKEDIEKSSKQRAMLAGATAVYSQFIT--QLTDENQSCCPVCQRV 687

  Fly   648 VTLEGDVVDPHGTVSG--GAAPKGANVLEELHAIKQIEKEYREIDSEIAQV----------EKQI 700
            ...|.::.:....:..  ..||......|     .:::|:.|..|..:..|          ||:|
  Rat   688 FQTEAELQEVISDLQSKLRLAPDKLKSTE-----SELKKKERRRDEMLGLVPMRQSIIDLKEKEI 747

  Fly   701 ASIENQALAFNKMKENL--DLRQHE----LTMCENRLAQ------TTFQQNQAEIEEMRERV--- 750
            ..:.|:..:.|:..:.|  |:.:.|    ..|.|...|:      |..::.|.|::::..::
  Rat   748 PELRNRLQSVNRDIQRLKNDIEEQETLLGTVMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQ 812

  Fly   751 ----------KTLEQQIIDSREKQ---KTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQR 802
                      :|::|...:.:|||   .|..:|| ::..||...:..:.:.|.:.|||:|..|.:
  Rat   813 AAKLQGVDLDRTVQQVNQEKQEKQHKLDTVSSKI-ELNRKLIQDQQEQIQHLKSKTNELKSEKLQ 876

  Fly   803 AEKSRANWKKREQ-EFETLQL--EITELQKSIETAKKQHQEMIDNLEKFKAELDAL--KVNSSSA 862
            .   ..|.::|:| |.:|::|  |:..|.:.|:.||:|...:...|||.:.|.:.|  :.|:|:.
  Rat   877 I---ATNLQRRQQMEEQTVELSTEVQSLNREIKDAKEQINPLEIALEKLQQEKEELIHRKNTSNK 938

  Fly   863 ASE----------------VTELEQAIKEQKDKLRDQNKEMRNQLV--------KKEKMLKE--- 900
            .::                :.::|..|::.||..:.|.:...|::|        .|||:.||
  Rat   939 MAQDKINDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNEVVIQLNECDKHKEKINKEMGT 1003

  Fly   901 -NQEIE------------LEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTR 952
             .|:|:            |.::|:..|.|::..:.|:..|.|..::.           ..|||
  Rat  1004 MRQDIDTQKIQERWLQDNLTLRKRREELKEVEEERKQHLKEMGQMQV-----------LQMKN-- 1055

  Fly   953 YDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDRE---------------EENFKETE-- 1000
                   .|:      |::|..|    |:..|..:.|.|:               |..|::.|
  Rat  1056 -------EHQ------KLEENID----TIKRNHSLALGRQKGYEEEILHFKKELREPQFRDAEEK 1103

  Fly  1001 -RRRNIVAMDKEKIKK-----------IIVKMDEEEQDQLNKAATEV------------------ 1035
             |...||....|.:.|           .|:|....:.:::||...::
  Rat  1104 YREMMIVMRTTELVNKDLDIYYKTLDHAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSD 1168

  Fly  1036 ------------NTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGELSGGQK 1088
                        |.|:..:   :|.|.             |.|:::           |..|.|||
  Rat  1169 ADENVSASDKRRNYNYRVV---MLKGD-------------TALDMR-----------GRCSAGQK 1206

  Fly  1089 SLVALSLVLAMLK--FSPAPLYILDEVDAALDMSHTQNIGSML------KQHFTNSQFLIVS 1142
            .|.:|.:.||:.:  .....:..|||....||..:.:::...|      :....|.|.|:::
  Rat  1207 VLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVIT 1268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	277/1427 (19%)
		ABC_SMC2_euk	1..>170	CDD:213240	37/201 (18%)
		SMC_hinge	520..637	CDD:214944	30/160 (19%)
		V_Alix_like	690..933	CDD:187408	72/325 (22%)
		P-loop_NTPase	<1073..1167	CDD:304359	18/78 (23%)
Rad50	NP_071582.2	rad50	2..1312	CDD:129694	277/1427 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910