Protein Alignment SMC2 and smc5

DIOPT Version :9

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_001180470.1
• Gene: smc5 / 566749
• ZFINID: ZDB-GENE-061013-288
• Length: 1073
• Species: Danio rerio
• Alignment Length: 1223
• Identity: 239/1223 - (19%)
• Similarity: 455/1223 - (37%)
• Gaps: 315/1223 - (25%)

  Fly     3 VKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVY 67
            :.::.:..|.:|.......|  |:...|.|.||:|||:|:.:||  ||::...:|....  |.|.
Zfish    42 IVRITMHNFLTYDHSEVFPG--PKLNMIVGANGTGKSSIVCAIC--LGLAGKTSVLGRG--DKVG 100

  Fly    68 KNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQV-VVGGKNKFLINGKLVQNKKVQDFF 131
            ...:.|..:.:|.|           :.|.....:.|||:: |...::.:::|.|....|.|::..
Zfish   101 LYVKRGCQRGSVEI-----------ELYRTRGNLIVTREIQVENNQSTWMLNKKHASQKAVEEAV 154

  Fly   132 CSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETK 196
            ..:.:.|.|....:.|.|:.:...|...|:|...|::.|..:........||.    .||.|:.:
Zfish   155 RELHIQVGNLCQFLPQEKVGEFAKMSNSELLEATEKSVGPPEMYEFHCELKTF----RTKERDLE 215

  Fly   197 VLLDEE--VLPKLVKLRQERSA--YQEYQKICRDIDFLIRIHISAK------YLKQCETLKTVEA 251
            .:..|:  .|.| .:.|.||:.  .:.|....|.:|   ||.:..|      |....:.|:.|:.
Zfish   216 NVCKEKGNFLEK-ARQRNERNKLDVERYYMKKRHLD---RIQMLEKKKPWVEYETARKELEGVKK 276

  Fly   252 NEHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGS 316
            ...:::.::...|......|.::.|:|:.::.::||: .||                     |..
Zfish   277 ERDEMKRKLRFLKEAQEPLLRKIRSVESELQPIEQQM-KEM---------------------TNR 319

  Fly   317 LKAAQGTIQQDEKKIRMASKNIEDDERALAKK---EADMAKVQGEFESL---KEADARDSKAYED 375
            :|.|....:|...::.:.:|.::|.::.::.|   |||..|..|..:.:   .:.:.::....||
Zfish   320 IKEATQKCKQKHDQLELKNKEVDDIKQDMSLKQTEEADRQKRIGHTQLMIRDLQKELQNMGTIED 384

  Fly   376 AQKKLEAVSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTN 440
            ...::||:        |.|...:||:           :..:::..::||
Zfish   385 VTPQIEAI--------NAELRNIQEE-----------RARLESESLDLR---------------- 414

  Fly   441 DAAYVKDKKLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELD--RCNASR 503
                 :||   |::..|...|:.:|:|||      :.:|.:...|..|.||....|:  |.|..|
Zfish   415 -----RDK---DEITGEFARLQNRLRSLD------DMMKIKEEKLRSRFRDTYTALEWLRKNRDR 465

  Fly   504 YDLQYQDP----------------EPNFDRRKVRGLVGKLFQVKD----MQNSMALVQTAGGSLY 548
            |:....:|                |.:.....:|..|   ||.:|    ..|.|...|..  .:.
Zfish   466 YEGVVHEPMMLVINVRDARHAKYIETHISVNDLRAFV---FQRQDDNDKFMNEMRDTQRL--RVN 525

  Fly   549 SYVTDDDVTSKKILQRGNLQRRVTLIPINKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRY 613
            |.:...:..||:...|          ||..::.    ...:.|.:....|.
Zfish   526 SIIAPTESCSKRPPSR----------PIETLKP----YGFISYLREMFDAP-------------- 562

  Fly   614 YEPVMKF-CFG--------GT--------LICKDLIVAKQISYDPRINCRSVTLEGDVVDPHGTV 661
             |.||.: |..        ||        .:.|||.:....:.:.|.|.:......:|      |
Zfish   563 -EEVMSYLCHQYRVNDVPIGTEKTKGMIESVIKDLQLRTIYTAEERYNVKKSAYSNNV------V 620

  Fly   662 SGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNKMKENLDLRQHELTM 726
            |..:|.:....|.....:    :|.|:::.::...|:|..||:.:..|..:.:.|||.|.:||
Zfish   621 SSNSALRPPQFLTTTIDV----EERRQLEEQLRAAERQKQSIDQRMAAIREQQANLDRRDNEL-- 679

  Fly   727 CENRLAQTTFQQNQAEIEEMRERVKTLEQQII---DSREKQKTSQAKIVDIEAKLADAKGYRERE 788
                      :.|:.::.:::.:.:.|||:|.   ||..:.:.::..:|.||.: |:||
Zfish   680 ----------RANKKKLSDLKSKKRQLEQKISTKQDSLRQMEQNEINLVAIEEE-ANAK------ 727

  Fly   789 LNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELD 853
             .||.|..|||......|....|.|.                             |:||.
Zfish   728 -IAAVNNKKVTIMGEYLSHLQSKARL-----------------------------NMEKV----- 757

  Fly   854 ALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQLVKKEKMLKENQEIELEVKKKENEQKKI 918
            .|.:.|:..::|.|:||..::|...:|:                     ..|::..|.:..:..:
Zfish   758 YLALQSAGLSAEKTKLETDVRESSAELK---------------------RAEVDYTKLDKIKTNL 801

  Fly   919 SSDAKEAKKRMEALEAKYPW---IPEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKM--- 977
            ....|...||...:....|.   :|||.                 |.|.:.|.:..::.|.|
Zfish   802 LMTCKTLMKRASEICNMTPGETAVPEEL-----------------HAAFSLLPETLDEIDAMLNE 849

  Fly   978 ERT-------LNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEV 1035
            |||       |:...:...:|.|:..|..|:..:....:....::.|.:..|...:.|.|....:
Zfish   850 ERTRAECFTGLSDAVVDEYNRREQEIKNLEKELDDKTNELTTYRRNIAEAKERWLNPLKKLVELI 914

  Fly  1036 NTNFSGIFSSLLPGAEAKLNPVHTNGC-LTGLEIKVGFNGIWKESLGEL-----SGGQKSLVALS 1094
            |..||..|.|:....|..|:..:.... ..|:.|:|.|..  ...:.||     |||::|:..:.
Zfish   915 NVRFSDFFQSMQCAGEVDLHSENEEEYDKYGIRIQVQFRR--NTRMHELTPHHQSGGERSVTTML 977

  Fly  1095 LVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQ---HFTNSQFLIVSLK 1144
            .::::.:.:..|..::||::..:|..:.:.:..::.:   ....||:..::.|
Zfish   978 YLMSLQELNRCPFRVVDEINQGMDPVNERRVFDIVVRAACGVNTSQYFFITPK 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	239/1223 (20%)
		ABC_SMC2_euk	1..>170	CDD:213240	39/167 (23%)
		SMC_hinge	520..637	CDD:214944	25/137 (18%)
		V_Alix_like	690..933	CDD:187408	49/245 (20%)
		P-loop_NTPase	<1073..1167	CDD:304359	13/80 (16%)
smc5	NP_001180470.1	ABC_SMC5_euk	40..>185	CDD:213244	37/159 (23%)
		Smc	42..1030	CDD:224117	238/1221 (19%)
		ABC_SMC5_euk	<950..1052	CDD:213244	15/83 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810