DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and si:dkey-119f1.1

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_001121806.1	Gene:	si:dkey-119f1.1 / 557127	ZFINID:	ZDB-GENE-070705-287	Length:	1090	Species:	Danio rerio

Alignment Length:	1203	Identity:	245/1203 - (20%)
Similarity:	476/1203 - (39%)	Gaps:	270/1203 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 FDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDLVYKNGQAGITKATVTIVFDNT- 86
            |.|....:.|.||||||.:|.::...||...|...|.|:|:..| |.|:   :.|.|:|...|.
Zfish    71 FGPNVNFVVGNNGSGKSAVLTALIVALGGKALTTNRGSSLKGFV-KEGE---SSADVSITLRNRG 131

  Fly    87 NPAQCPQGYEKCREISVTRQVVVGGKNKFLI---NGKLVQNKK-----VQDFFCSIQLNVNNPNF 143
            ..|..|:.:.  :.|.|..::...|...:.:   .|:||..||     :.|.|   .:.|:||..
Zfish   132 RDAYKPEKFG--QSIVVDLRISSEGIRTYKLKSHTGQLVSAKKEELVSILDHF---NIQVDNPVS 191

  Fly   144 LIMQGKIQQVLN-----------MKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETKV 197
            ::.|...:..|:           ||..::..|.|:.:    |..|   ||||.:....|.|||.:
Zfish   192 ILTQEMSKHFLHSKGEGDKYKFFMKATQLDQMKEDYS----YIMK---TKTLTQNTVEKHRETLL 249

  Fly   198 LLDEEVLPKLVKLRQERSAYQ------EYQKICRDIDFLIRIHISAKYLKQCETLK-TVEANEH- 254
            .|.:       |.|.:...|:      |.|:...::...:...:.|:..::.:.:| .:.|.|.
Zfish   250 ELKQ-------KFRDKEERYKSLASLDEMQQKLNELKNQMAWALVAEMEQEMKPMKEQITAEERS 307

  Fly   255 --KIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSL 317
              |.:.::...|       .:|:......|::|.|::: :...::.|:.:.|..::........|
Zfish   308 TVKYDQKVEEWK-------GKVDEANKISKQLQDQLES-VSERMQQLQPECSELKSRVQERNREL 364

  Fly   318 KAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEA 382
            |.|:..:.:....:|    ::|.|:..|.|:..::.      .|:.:.::.|::|..:....::|
Zfish   365 KTAEAALHRKRTNLR----DLEKDKDQLNKRIKELK------HSISQMNSADTQARVEKMNHIQA 419

  Fly   383 VSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKD 447
            ..:.||..:    |||.:|:    :||.:|..:.|.     ||.| :.::|:      |.....|
Zfish   420 ELEELSFRD----STLAQQI----DQFKQACESAKE-----RHAR-MSRERQ------DLQRAID 464

  Fly   448 KKLHDQLVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPE 512
            .|..|...:| .:...||:..   |.|...|.:..::.|.|.:
Zfish   465 SKQRDLAAME-SSRNNQLRRF---GEHIPALMEAIDEAHHRGK---------------------- 503

  Fly   513 PNFDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKI-------LQRGNLQRR 570
               .|.|..|.:|...:::|...::|:.......:.::..|:....:::       .|||   ||
Zfish   504 ---FRMKPVGPLGFCIRLRDQDLALAVECCLKALMLAFCCDNHADERELERIMGRFYQRG---RR 562

  Fly   571 VTLIPINKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYE------PVMKFC------FG 623
            ..:|.       |...|::....|:        |:|..||....:      ||:..|      ..
Zfish   563 PQIIV-------SRFTNMLYNVGNR--------AVSHPDYPTVLQALDIENPVVANCLIDMRGIE 612

  Fly   624 GTLICKDLIVAKQISYD-----PRINCR-SVTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQI 682
            ..|:.||...|:::...     || ||| :.|.:||.|..:...|           .|.|..:.:
Zfish   613 TILLIKDNRDARRVMQSKGGQAPR-NCREAFTRDGDQVYTNRYYS-----------SEQHRAQYL 665

  Fly   683 EKEYREIDSEIAQVEKQIASIENQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMR 747
            .::          ||::|..:::   |....:..||                .|||:..::.|..
Zfish   666 SRD----------VEEEIRHLQS---ALQTQRAQLD----------------RFQQDMQQVGEEE 701

  Fly   748 ERVKTLEQQIIDSREKQKTSQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKK 812
            .:.:||.::..|.|:|.:....|   ::|:|.:.:...|.:    :.::|..::..|:.......
Zfish   702 RQNQTLLRRAYDDRKKVQERSRK---LQAELTELQNVEEPQ----SEDLKPLEEELEELSGRISV 759

  Fly   813 REQEFETLQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQK 877
            ..:|||.|:.:....:|..|.|:|..::..:.:.....|::.:|...:::..||...:...|..:
Zfish   760 CGEEFEALRRQTQTCKKEYEEAEKVFRQKKEAVNSIVEEVEPIKERLNNSDQEVERSKHHRKHYE 824

  Fly   878 DKLRDQNKEMRNQLVKKEKMLKENQEIELEVKKKEN---EQKKISSDAKEAKKRMEALEAKYPWI 939
            :| |..:.:|...|  |..:.::.||::..:.|...   |:..:...||.....:..|::|   |
Zfish   825 EK-RKTHLQMIETL--KTSLNQKEQELQAAIAKASEICPERSDVRRTAKSLDSEINRLKSK---I 883

  Fly   940 PEEKNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLN-MNAIMVLDREEENFKETERRR 1003
            ..:::..|.::|    ...:.|||..|..|:..:...::..:: ::.||.            .|.
Zfish   884 NTQQDQQGHRDT----IVREYHEAREKFGKISRQVKGLDAFIHQLSKIMT------------TRH 932

  Fly  1004 NIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEI 1068
            |:.|                  :.....:.....||..:.|.  .|.:.|:...|.|..|: :.:
Zfish   933 NVYA------------------EMRMYLSVRCKYNFHSMLSQ--RGYKGKMIFDHKNEILS-ISV 976

  Fly  1069 KVGFNGIWKESLGE---LSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQ-NIGSML 1129
            :.|..|  |..|.:   ||||::|...:..||::.:.:..|...|||.|..:||.:.: ::..||
Zfish   977 QPGEGG--KADLSDMRSLSGGERSFSTVCFVLSLWEIAEVPFRALDEFDVYMDMVNRRISMDMML 1039

  Fly  1130 K----QHFTNSQFLIVSLKDGLFNHANVLFRTL 1158
            |    |.:  .||:.::.::......|.|.|.|
Zfish  1040 KIAASQRY--RQFIFLTPQNMSSLPINSLIRVL 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	245/1203 (20%)
		ABC_SMC2_euk	1..>170	CDD:213240	44/166 (27%)
		SMC_hinge	520..637	CDD:214944	25/135 (19%)
		V_Alix_like	690..933	CDD:187408	45/245 (18%)
		P-loop_NTPase	<1073..1167	CDD:304359	27/94 (29%)
si:dkey-119f1.1	NP_001121806.1	Smc	52..1074	CDD:224117	245/1203 (20%)
		ABC_SMC6_euk	52..>208	CDD:213243	40/145 (28%)
		TBPIP	<241..319	CDD:284512	15/84 (18%)
		Laminin_II	319..>396	CDD:283628	15/88 (17%)
		ABC_SMC6_euk	<982..1077	CDD:213243	27/93 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810