Protein Alignment SMC2 and rad50

DIOPT Version :9

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_005167995.1
• Gene: rad50 / 553029
• ZFINID: ZDB-GENE-050506-110
• Length: 1312
• Species: Danio rerio
• Alignment Length: 1440
• Identity: 278/1440 - (19%)
• Similarity: 523/1440 - (36%)
• Gaps: 441/1440 - (30%)

  Fly     3 VKKLVLDGFKSYG---RRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQD 64
            ::|:.:.|.:|:|   :..::..|....|.:.|.||:||:.|::.:.::....
Zfish     4 IEKMSILGVRSFGVEDKDKQVISFFSPLTVLVGPNGAGKTTIIECLKYITSGD------------ 56

  Fly    65 LVYKNGQAGIT-------------KATVTIVFDNTN--------PAQCPQG-------------- 94
              :..|..|.|             :|.:.:.|.:.|        ..||.|.
Zfish    57 --FPPGSKGNTFVHDPKDAHETDVRAQIRLQFRDVNGDAVAVQRSMQCTQKGKKTEFKTLEGVIT 119

  Fly    95 ----------YEKCREISVTRQVVVG-GKNKFLINGKLVQNKKVQDFFCSIQLNVNNPNFLIMQG 148
                      ..||.||.  |:::.. |.::.::|..:         ||    :....|:.:.:|
Zfish   120 RIKHGEKVSLSSKCAEID--REMISSLGVSRAVLNHVI---------FC----HQEESNWPLSEG 169

  Fly   149 KIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETKVLLDEEVLPKLVKLRQE 213
            |   .|..|..|:.|                ||:.:      ||.||           |..|||:
Zfish   170 K---ALKQKFDEIFS----------------ATRYI------KVLET-----------LRTLRQK 198

  Fly   214 RSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHKIEDRIANCKATHAKNLAEVESIE 278
            ::   ...|.|:         :..|||||         |:.|.:: |....:|....||   |.:
Zfish   199 QT---NTVKSCQ---------MELKYLKQ---------NKDKAQE-IRELLSTKETQLA---SSK 238

  Fly   279 NSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGTIQQDEKKIRMASKNIEDDER 343
            .||..::.|||.        ||.:|:   .:|::....:|     :..|.|.:....|.:|||.|
Zfish   239 ESVNRIEGQIDP--------LERRLN---DIESSLGKVMK-----LDNDIKALDSRKKQMEDDNR 287

  Fly   344 ALAKKEADMAKV-QGEFESLKEADARDSKAYEDAQKKLEAVSQGL--STNENGEASTLQEQLIVA 405
            .|.:|   |.:| ||..:.|::......:..::.:|:|....:.|  :..|....:.::.:|:|.
Zfish   288 ELEEK---MEQVFQGSDDQLQDMYQNHQRTVKEKEKRLVECQRELERAGRECQRMNRIKSELLVE 349

  Fly   406 K-----------EQFSEAQTTIKT----SEIE-----------------------------LRHT 426
            :           :...:..|.:||    .|:|                             |..|
Zfish   350 QGRLQLEADRHTQNIKKRDTQVKTLASFLELEGYDRTPLSERQLQSFYRQIKERLDQDSEALNQT 414

  Fly   427 RGVLKQREGETQTN--DAAYVKDKK------------LHDQLVVEIKNLERQLQSLDYEGGHFEK 477
            ...::|:|.:.|.|  |   ::|||            |..:...|:||::..||.|:   |...:
Zfish   415 MHDMQQKETQKQHNIDD---LRDKKTGLERTIELKKDLQAKKQQELKNIKSDLQKLE---GSSNR 473

  Fly   478 LKQRRNDLHMRKRDLKRELDRCNASRYDLQYQDPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQT 542
            |::...:|...:|:|...:..|...  .|:.:..|...::.::.....||.|..:|.|:....:.
Zfish   474 LQELDTELQKAERELDNAVQACTVD--SLKVEVTELLKEKAQLDQAQRKLDQEMEMLNTHTTARA 536

  Fly   543 AGGSLYSYVTDDDVTSKKILQRGNLQ---------------------------RRVTLIPINK-I 579
            ....:.....|.:...:||..|.|.:                           .|..:..:|| :
Zfish   537 QMDMMKKTKMDKEEQVRKIKSRHNEELVSLLGHFPNKKELEDWIYSKSREIKSTREQITKMNKEL 601

  Fly   580 QSGSLNRN------------VVEYAQ---NKVGAENVQWAMSLIDYDRYYEPVMKFC-------F 622
            .||...::            :.:|.:   |..|:::.|..:|.:      |..::.|       .
Zfish   602 ASGEQKKSHYTAEIKRKEEQLAKYEERLFNVCGSQDFQSDLSKL------EDELEKCSKQRAMLA 660

  Fly   623 GGTLICKDLIVAKQISYDPRINCRSVTLEGDVVDPHGTVSGGAAPKGA---NVLEEL-------- 676
            |.|.:....|             ..:|.|||...|   |.....|..|   :|:.::
Zfish   661 GATAVYSQFI-------------SQLTEEGDPCCP---VCQRVFPSEAELQDVINDMQSKLRLVP 709

  Fly   677 -------HAIKQIEKEYREI-------DSEIAQVEKQIASIENQALAFNKMKENL--DLRQHELT 725
                   |.:|:.|:...|:       .|.:...||::..:.||....|:..|.|  |:.:.|..
Zfish   710 DKLKNTEHDLKRKERRRDEMMTLKPIRQSLVELQEKELPELRNQLQRVNRDIEKLKGDIEEQETL 774

  Fly   726 MC----ENRLAQTTFQ------QNQAEIEEMRERV-------------KTLEQQIIDSREKQKT- 766
            :|    |...|:...|      :.|.:::::..::             :|::|.   |:|||:|
Zfish   775 LCTLVSEEETAKACLQDISLMDRFQLDLKDVERKIAQHAAKLQGVDLSRTMQQV---SQEKQETQ 836

  Fly   767 ----SQAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSR--ANWKKREQ------EFET 819
                :.:..::::.||...:..:.:.|.::.|||     |.||.:  :|.:||:|      ||.|
Zfish   837 HRLDTTSSKIELKRKLIQDQQEQIQALRSSVNEI-----RGEKLQISSNMQKRQQLEEQCVEFST 896

  Fly   820 LQLEITELQKSIETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQN 884
               ||..|.:.|..||:|...:...|||.:.|...|.........|..|...||||:...:....
Zfish   897 ---EIQTLHRDIRDAKEQASPLAATLEKLQQEKQDLVERRRKKQEEGQEKINAIKEKMKNITLFE 958

  Fly   885 KEMRNQLVKKEKMLKENQEIELEVKKK-----ENEQKKISSDAKEAKKRMEALEAKYPWIPEEKN 944
            ||:...:.:.:...||.:|.||:...|     |.:::|.:.|....::.::..:.:..|:.:...
Zfish   959 KEITKYIEEGKDSYKEQKETELQEMDKQLHEAEKQREKTNKDMGNIRQDIDTQKVQERWLQDNLT 1023

  Fly   945 CFGMKNTRYDYSKEDPH-------EAGN-KLAKMQEKKDKMER---TLNMNAIMVLDR----EEE 994
            .    ..|.:..||...       |.|| ::.:::.::.::||   .|..|..:.|.|    |:|
Zfish  1024 L----RKRVEELKEVSRKREALIKEMGNMQVLQLRNERREVERKLEDLKKNRSVALGRQKGYEDE 1084

  Fly   995 NF---KETERRRNIVAMDKEKIKKIIVKMDE---EEQDQLNKA------------ATEVNTNFSG 1041
            ..   ||....:...|.|..:.|.|:::..|   ::.|...||            ..|:|.....
Zfish  1085 ILRFRKELNEDQYCRAEDLYRDKMIVMRTTELANKDLDIYYKALDQTIMRFHSMKMEEINKIIRD 1149

  Fly  1042 IFSSLLPGAEAKLNPVHTN---GCLTGLEIKVGFN--------GIWKESLGELSGGQKSLVALSL 1095
            ::.|...|.:.:...:.::   ....|::.:. :|        ....:..|..|.|||.|.:|.:
Zfish  1150 LWRSTYRGQDIEYVEIRSDVDENASAGVKRRT-YNYRVVMVKGDAALDMRGRCSAGQKVLASLII 1213

  Fly  1096 VLAMLK--FSPAPLYILDEVDAALDMSHTQNIGSML------KQHFTNSQFLIVSLKD------G 1146
            .||:.:  .....:..|||....||..:.:::...|      :....|.|.|:::..:      |
Zfish  1214 RLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSRQRNFQLLVITHDEDFVELLG 1278

  Fly  1147 LFNHANVLFR 1156
            ..|:....:|
Zfish  1279 RSNYVEHFYR 1288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	278/1440 (19%)
		ABC_SMC2_euk	1..>170	CDD:213240	37/215 (17%)
		SMC_hinge	520..637	CDD:214944	25/166 (15%)
		V_Alix_like	690..933	CDD:187408	67/285 (24%)
		P-loop_NTPase	<1073..1167	CDD:304359	22/106 (21%)
rad50	XP_005167995.1	rad50	2..1312	CDD:129694	278/1440 (19%)
		ABC_Rad50	4..>166	CDD:213207	31/190 (16%)
		Rad50_zn_hook	659..709	CDD:282302	12/65 (18%)
		Orbi_VP5	708..>877	CDD:279272	35/176 (20%)
		ABC_Rad50	<1195..1297	CDD:213207	21/94 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910