DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SMC2 and EMC10

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_730662.2	Gene:	EMC10 / 40396	FlyBaseID:	FBgn0052441	Length:	227	Species:	Drosophila melanogaster

Alignment Length:	196	Identity:	38/196 - (19%)
Similarity:	80/196 - (40%)	Gaps:	40/196 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 ICFVLGISNLQNVRAS------------ALQDLVYKNGQAGITKATVTIVFDNTNPAQCPQGYEK 97
            :.||||:     |.:|            .||..:..|.::...:..|||...|:..|...|....
  Fly     9 LIFVLGL-----VSSSWGFLEHDSWITVELQHSLAANSESFSFRGNVTIPSLNSGLANVEQPDLS 68

  Fly    98 CREISVTRQVVVGGKNKFL-INGKLVQNKKVQDFFCSIQLNVNNPNFLIMQGKIQQVL--NMKPK 159
            ..::.:.:::.:|  |:|. :...:|.:...:     .|...:|....::|.::..||  :::|.
  Fly    69 TADLDLLKKLALG--NEFYRLKATVVYSNGAK-----AQFITSNKACRLLQAQLNDVLWVSLEPS 126

  Fly   160 EV---LSMVEEAAGTSQYKTKRDATKTLIEKKETKVRETKVLLDEEVLPK------LVKLRQERS 215
            ..   :::.::.|..:...|:.|..|.|    ||:.....::...|:.|.      :.|:.:||.
  Fly   127 GYVTGITVSQDTAPATIECTQEDVNKLL----ETQFSTDVLIRHAELAPVPDTAGFIQKVERERE 187

  Fly   216 A 216
            |
  Fly   188 A 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	38/196 (19%)
		ABC_SMC2_euk	1..>170	CDD:213240	25/142 (18%)
		SMC_hinge	520..637	CDD:214944
		V_Alix_like	690..933	CDD:187408
		P-loop_NTPase	<1073..1167	CDD:304359
EMC10	NP_730662.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900