Protein Alignment SMC2 and LOC3291777

DIOPT Version :10

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: XP_557814.3
• Gene: LOC3291777 / 3291777
• VectorBaseID: AGAMI1_014685
• Length: 1213
• Species: Anopheles gambiae
• Alignment Length: 1335
• Identity: 314/1335 - (23%)
• Similarity: 581/1335 - (43%)
• Gaps: 294/1335 - (22%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            ||:|:::::|||||..:|.:|..||:...:.|.|||||||...:|.|||. ....|:|.:....|
Mosquito     1 MYLKEIIINGFKSYKLQTVVERLDPKHNVVVGRNGSGKSNFFSAIEFVLS-DEYNNLRPAQRVGL 64

  Fly    66 VYKNGQAGITK-----ATVTIVFDNTNPAQ-CPQGYEKCREISVTRQVVVGGKNKFLINGKLVQN 124
            :.|    |.:|     |.|.||||:::.:| .|....:.|    .|:.:...|:::.:||:....
Mosquito    65 INK----GTSKNRSDSAYVEIVFDHSSASQTTPSPGTETR----IRRTISATKDQYTVNGRNATR 121

  Fly   125 KKVQDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTK--------RDAT 181
            |::.:...::.|:..||.:::.|||:.|:...:|:::|.::.:..|...|..|        :||.
Mosquito   122 KEIDELLDTLGLSSCNPYYIVKQGKVSQLTTARPRQLLQLLYDIGGIRVYDEKLKEILKLWQDAD 186

  Fly   182 KTL--IEKKETKVRETKVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCE 244
            |.|  |..:.|.:.....||..:        ::|:.|:::.:|..|.:..::   :..|  :||
Mosquito   187 KGLQQIHAERTALANRLELLSSQ--------QREQRAFEQLEKKHRVLQSVV---LDKK--QQC- 237

  Fly   245 TLKTVEAN-----EHKIEDRIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLS 304
            .|..:||:     |.|.:.|....:.|.|.|.::|      :|:.|           |:.|::|:
Mosquito   238 VLAALEAHGQAGQEWKEKQRALLEQKTEAVNRSKV------LKQAQ-----------KDNESELA 285

  Fly   305 AKRALEA-TATGSLKAAQGTIQQD------EKKIR--MASKNIEDDERALAKKEADMAKVQGEFE 360
            :..||:| .||.:|:..:...:.|      :|::|  :..:|.|.::  |.|...::|::|.:.:
Mosquito   286 SAEALKADQATEALRLDRHKTRVDLKMDDLQKELRRLLGLQNSEQEQ--LEKDNEEIAELQAKLQ 348

  Fly   361 SLKE--ADARDSKAYED----AQKKLEAVSQGLSTNENGEASTLQEQLIVAKEQFSEAQTTIKTS 419
            :|..  |..::.:|..|    .:|:|.  |:.|:....||....:|:    :::|.:.:......
Mosquito   349 TLSREWAKVQEQRAALDFDVLMKKQLR--SERLNKLRRGEQFATREE----RDRFLQQEIAYAGK 407

  Fly   420 EIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQLVVEIKNLERQLQSLDYEGGHF--------E 476
            :||.........:|..||...:.|  .:|..|::...|::.|..|.|       |:        |
Mosquito   408 QIESDSKALAEAKRARETLAKELA--SEKASHERDEAELRELTEQEQ-------HYASQLAQISE 463

  Fly   477 KLKQRR-----------------ND----LHMRKRDLKREL-----DRCNASRYDLQYQDPEPNF 515
            :|::.:                 ||    :..:::.|:::|     ..|.:.|..|:....:.|.
Mosquito   464 RLREAKGVLDDLLANEAAQTLELNDCKALIARQEQMLRKKLGPATYQGCKSVRTVLEALCAQGND 528

  Fly   516 DRRK--VRGLVGKLFQVKDMQNSM--ALVQTAGGSLYSYVTDDDVTSKKIL---QRGNLQRRVTL 573
            |.|.  .:|..|::..:.....::  |:...||..|:.:|.:.|..:.:|:   .|..|......
Mosquito   529 DGRAEVAQGYCGRVLDLFHCDKTIYQAVETVAGNKLFYHVVESDRIASEIIALCTRHKLPGEYNF 593

  Fly   574 IPINKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQIS 638
            :|:|:     |:.:..:|..:   :.:|:..:||:.||..||||.:..||.||:|::|..|.:::
Mosquito   594 MPLNR-----LHASKQKYPPD---SASVRPLISLLTYDGCYEPVFRHIFGKTLLCEELETAARVA 650

  Fly   639 YDPRINCRSVTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQI-AS 702
            ....:.|  ||.|||.|.| |.:|||.....|:.:       |......::|.:::|:|..: .:
Mosquito   651 QQYGLCC--VTHEGDTVRP-GVLSGGYRSPTASTI-------QARLLLSDLDDKMSQLEDSLKTT 705

  Fly   703 IENQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTS 767
            :|:...|...:|.:      ||   |:.......::.:..:|.:|||::...:
Mosquito   706 VESIPPAARLIKGS------EL---EHTNEARKLERAKQHVESVRERIRAFPE------------ 749

  Fly   768 QAKIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLE-----ITEL 827
              :...:||||::|..    ::.|...|:::.:.:.:..|..:..:   |:.:..|     |.:|
Mosquito   750 --RCRKLEAKLSEAGS----KIRALETELQLVRAKVDGLRREFATK---FDCVLSEEDVRVIEQL 805

  Fly   828 QKSI-ETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRNQL 891
            ..:| |..:::|       |.|.|:|.|               |||..:.:::|.......|:.|
Mosquito   806 DAAIREIERRKH-------EAFNAQLQA---------------EQAKAKIENRLNTVLLPRRDAL 848

  Fly   892 VK----------KEKMLKENQEIELEVKKKENEQKKISSDAK---EAKKRMEALEAKYP-WIPEE 942
            |.          ||.:|:..:|.:....|.:|.|||:..:.:   :|.:|...|.|:.. |  .|
Mosquito   849 VASGGGARCRELKELILQCKREQDAFTLKIDNLQKKMKENEQLILKATERRNKLAAELDRW--SE 911

  Fly   943 KNCFGMKNTRYDYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVL---DREEEN------FKE 998
            |    :|.|....|..||.:..::..|...:.:..:....:.|:.||   ||..:.      .||
Mosquito   912 K----LKTTEEALSIGDPQQMRHEARKRDLENEARQYAEQIGALGVLPAIDRAYQRMELPTLMKE 972

  Fly   999 TERRR---------NIVAMDK-----EKIKKIIVKMDEEEQ-----------------DQLNKAA 1032
            .:|..         |..|.|:     :::..|..|:.:.||                 |.|.:..
Mosquito   973 LDRTSKQLKKFGSVNQAATDESTRLSQELSSIDRKLQQLEQSRALHDASIQQLRAQRTDSLERTF 1037

  Fly  1033 TEVNTNFSGIFSSLLP---------------GAEAKLNPV-HTNG-----CLTGLEIKVGF--NG 1074
            ..|..||..|||.|:|               .||..:... |.:|     ...||.::|.|  ||
Mosquito  1038 DSVRRNFGEIFSKLVPAGCGQLSLQTADLDEAAEGAIERTDHPDGGEPVDRYVGLRLEVSFRGNG 1102

  Fly  1075 IWKESLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFL 1139
            .....:..||||||:|||::|:.|:.:..|||.|:.||:|.|||..|.:.|...:.....:|||:
Mosquito  1103 ELMREMNALSGGQKTLVAIALIFAIQRNKPAPFYLFDEIDQALDAQHRKVIAGEIAALSASSQFI 1167

  Fly  1140 IVSLKDGLFNHANVLFRTLFEEGVSTITRQVSRQA 1174
            .::.:..|..||...|...:...:|.|.....:||
Mosquito  1168 TITFRRELLEHAAKYFGVRYRNNMSFIDPVTKQQA 1202

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	SMC_N	2..1162	CDD:481474	309/1320 (23%)
LOC3291777	XP_557814.3	None