Protein Alignment SMC2 and SMC3

DIOPT Version :9

• Sequence 1: NP_610995.1
• Gene: SMC2 / 36653
• FlyBaseID: FBgn0027783
• Length: 1179
• Species: Drosophila melanogaster
• Sequence 2: NP_523374.2
• Gene: SMC3 / 32627
• FlyBaseID: FBgn0015615
• Length: 1200
• Species: Drosophila melanogaster
• Alignment Length: 1294
• Identity: 299/1294 - (23%)
• Similarity: 584/1294 - (45%)
• Gaps: 226/1294 - (17%)

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            |::|::::.|||||..:|.:|.||.....:.|.|||||||...:|.|||. ....::|....|.|
  Fly     1 MHIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLS-DEFTHLRPEQRQSL 64

  Fly    66 VYKNGQAGITKATVTIVFDNTN---PAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKV 127
            :::...|.:..|.|.|:|||::   |..        :|....|:|:...|:::.:|.|:|...:|
  Fly    65 LHEGTGARVISAYVEIIFDNSDNRVPID--------KEEIFLRRVIGAKKDQYFLNKKVVPRNEV 121

  Fly   128 QDFFCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKV 192
            .:...|...:.:||.:::.||||.|:........|.::.|.|||..|..:::.:..|:.:.::||
  Fly   122 VNLLESAGFSSSNPYYIVKQGKINQMATAADSYRLKLLREVAGTRVYDERKEESLNLLRETDSKV 186

  Fly   193 RETKVLLD--EEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANEHK 255
            .:....|.  |:.|..|.:.::|...||::.|..|.::: ||.....|..|:......::.....
  Fly   187 EKISEYLKTIEDRLQTLEEEKEELKEYQKWDKTRRTLEY-IRYETELKDTKKALDELQLQRKSSS 250

  Fly   256 IEDRIANCKATHAKNLAEVESIENSVKEMQQQIDA-EMGGSIKNLETQ--LSAKRALEATATGSL 317
            .:.:|.|.:...|:.  :::.::.::||.::::.: :...|:...|.|  |..|..|:.|.....
  Fly   251 DKKKIYNIEIQKAQE--KIKDVQKNLKEAKKKVQSTKEERSVLMTEQQQLLREKTKLDLTIVDLN 313

  Fly   318 KAAQGTIQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEA 382
            ...||    |.|....|.:.:::.:..:|::|.::..|:.::|::|..:       ||..::|:.
  Fly   314 DEVQG----DNKSKERADQELKNLKVTIAEREKELDDVKPKYEAMKRKE-------EDCSRELQL 367

  Fly   383 VSQGLSTNENGEASTLQEQLIVAKE----QFSEAQTTIK--TSEIELRHTRGVLKQREGETQTND 441
            ..|             :.:.:.||:    |||..:...|  |:|:     :.:.||
  Fly   368 KEQ-------------KRKELYAKQGRGSQFSSREDRDKWITNEL-----KSISKQ--------- 405

  Fly   442 AAYVKDKKLHD-QLVVEIK---NLERQL-QSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNA 501
               .:||..|. :||.::|   ..|:.| |.::......|:|:.:.::.:.:..:||:..|:..:
  Fly   406 ---TRDKIAHHAKLVEDLKKDATSEKDLGQKIEEHSSELEQLRLQIDEHNKKYYELKKTKDQHQS 467

  Fly   502 SRYDL---------QYQDPEPNFDR--RKVRGLVGKLF-----QVKDMQNSM------------- 537
            .|.:|         |.|..:....|  :.:|.:.||..     .|:.:.:|.
  Fly   468 MRNELWRKETQMTQQLQTHKEELSRADQALRSMAGKPILNGCDSVRKVLDSFVERGGQSAEIARA 532

  Fly   538 -----------------ALVQTAGGSLYSYVTDDDVTSKKILQRGN---LQRRVTLIPINKIQSG 582
                             |:..||...|:.::.:.:....:||:..|   |...||.:|:|::|.
  Fly   533 YYGPVIENFSCDKTIYTAVEVTAANRLFHHIVESEYEGTQILKEMNKLKLPGEVTFMPLNRLQV- 596

  Fly   583 SLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISYDPRINCRS 647
                .:.:|..:......:    |.:.||..::..:::.||.||||::|..|.:::....::|
  Fly   597 ----KIHDYPDDPDSIPMI----SKLKYDEQHDKALRYIFGKTLICRNLERATELAKSTGLDC-- 651

  Fly   648 VTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIENQALAFNK 712
            |||:||.|...|:::||......:.||       ::|:..|..|:||:.||:::.:.|:   ...
  Fly   652 VTLDGDQVSSKGSLTGGYFNTSRSRLE-------MQKKRTEYTSQIAEFEKKLSKLRNE---LKS 706

  Fly   713 MKENLDLRQHELTMCENRLAQT--TFQQNQAEIEEMRERVKTLEQ----------QIIDSREKQK 765
            .:.|::....|:...|.:..::  .|::.|.||..|:|.:..:||          |...|.|..
  Fly   707 TENNINSIVSEMQKTETKQGKSKDVFEKVQGEIRLMKEELVRIEQYRAPKERSLAQCKASLESM- 770

  Fly   766 TSQAKIVDIEAK---LADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITEL 827
            ||....::.|.|   ::......:||::...::|:         |.|.:.:|...:.:|.|:.:.
  Fly   771 TSTKSSLEAELKQELMSTLSSQDQREIDQLNDDIR---------RLNQENKEAFTQRMQFEVRKN 826

  Fly   828 QKS---IETAKKQHQEMIDNLEKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMRN 889
            :..   |....::..|:|..|::...|....|:|:..     |||..|.|..| |:....:|:..
  Fly   827 KLDNLLINNLFRRRDELIQALQEISVEDRKRKLNNCK-----TELVSAEKRIK-KVNSDLEEIEK 885

  Fly   890 QLVKKEKMLKE-NQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRY 953
            ::::..::.|| .||:|..|:|::..::.::.|:|:.:|          |..:|    .|.|.:.
  Fly   886 RVMEAVQLQKELQQELETHVRKEKEAEENLNKDSKQLEK----------WSTKE----NMLNEKI 936

  Fly   954 DYSKE-----------DPHEAGNKLAKMQEKKDKMERTL------NMNAIMVLDREEENFKETER 1001
            |...|           ||......|..:.::.:|..:.|      |..|:.......|..::..|
  Fly   937 DECTEKIASLGAVPLVDPSYTRMSLKNIFKELEKANQHLKKYNHVNKKALDQFLSFSEQKEKLYR 1001

  Fly  1002 RRNIVAMDKEKIKKIIVKMDEEEQDQLNKAATEVNTNFSGIFSSLLP-GA-----EAKLN----- 1055
            |:..:.:..:||..:|..::.::.:.:.....:|..||:.:|..|:| ||     :.|.|
  Fly  1002 RKEELDIGDQKIHMLIQSLEMQKVEAIQFTFRQVAQNFTKVFKKLVPMGAGFLILKTKDNEGDEM 1066

  Fly  1056 --PVHTNGCLTGLEIKVGFNGIWKE--SLGELSGGQKSLVALSLVLAMLKFSPAPLYILDEVDAA 1116
              .|..:...||:.|:|.|.|:..|  .:.:|||||||||||:|:.::.|..|||.|:.||:|.|
  Fly  1067 EKEVENSDAFTGIGIRVSFTGVEAEMREMNQLSGGQKSLVALALIFSIQKCDPAPFYLFDEIDQA 1131

  Fly  1117 LDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLFNHANVLFRTLFEEGVS---TITRQVSR 1172
            ||..|.:.:.:|:.:....:||:..:.:..|..:|:..:...|...||   .:||:.::
  Fly  1132 LDAMHRKAVANMIHELSDTAQFITTTFRPELLENAHKFYGVRFRNKVSHIDCVTREEAK 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	297/1288 (23%)
		ABC_SMC2_euk	1..>170	CDD:213240	52/171 (30%)
		SMC_hinge	520..637	CDD:214944	30/154 (19%)
		V_Alix_like	690..933	CDD:187408	57/261 (22%)
		P-loop_NTPase	<1073..1167	CDD:304359	34/98 (35%)
SMC3	NP_523374.2	SMC_N	2..1180	CDD:280601	295/1281 (23%)
		ABC_SMC3_euk	3..>159	CDD:213239	50/164 (30%)
		SMC_hinge	533..643	CDD:214944	25/118 (21%)
		TMPIT	678..>760	CDD:285135	20/91 (22%)
		CHD5	<780..>822	CDD:282299	9/50 (18%)
		P-loop_NTPase	<1088..1182	CDD:304359	33/93 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464472
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1196
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I342
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11228at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.800