DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMC2 and smc2

DIOPT Version :9

Sequence 1:	NP_610995.1	Gene:	SMC2 / 36653	FlyBaseID:	FBgn0027783	Length:	1179	Species:	Drosophila melanogaster
Sequence 2:	NP_955836.2	Gene:	smc2 / 321452	ZFINID:	ZDB-GENE-030131-105	Length:	1199	Species:	Danio rerio

Alignment Length:	1207	Identity:	504/1207 - (41%)
Similarity:	787/1207 - (65%)	Gaps:	49/1207 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYVKKLVLDGFKSYGRRTEIEGFDPEFTAITGLNGSGKSNILDSICFVLGISNLQNVRASALQDL 65
            ||:|.:||:|||||..||||.||||.|.|||||||||||||||||||:||||||..|||:.||||
Zfish     1 MYIKSIVLEGFKSYAERTEINGFDPFFNAITGLNGSGKSNILDSICFLLGISNLSQVRATNLQDL 65

  Fly    66 VYKNGQAGITKATVTIVFDNTNPAQCPQGYEKCREISVTRQVVVGGKNKFLINGKLVQNKKVQDF 130
            |||||.||||||||:|.|||:|..|.|.|:|...||::|||||:||:||:||||....|.:|||.
Zfish    66 VYKNGLAGITKATVSITFDNSNKKQSPLGFETHDEITITRQVVIGGRNKYLINGVNANNLRVQDL 130

  Fly   131 FCSIQLNVNNPNFLIMQGKIQQVLNMKPKEVLSMVEEAAGTSQYKTKRDATKTLIEKKETKVRET 195
            |||:.||||||:||||||:|.:||||||.|:|:|:||||||..|:.|:.:.:..||||:.|::|.
Zfish   131 FCSVGLNVNNPHFLIMQGRITKVLNMKPPEILAMIEEAAGTRMYECKKISAQKTIEKKDAKLKEI 195

  Fly   196 KVLLDEEVLPKLVKLRQERSAYQEYQKICRDIDFLIRIHISAKYLKQCETLKTVEANE--HKIED 258
            :.:||||:.|.:.||::||::|.||||:.|:|:.|.|::::  ||..|.....:::||  .:::.
Zfish   196 QTILDEEITPAMEKLKEERASYLEYQKLMREIEHLSRLYVA--YLFVCAEETKLKSNEELQEMQS 258

  Fly   259 RIANCKATHAKNLAEVESIENSVKEMQQQIDAEMGGSIKNLETQLSAKRALEATATGSLKAAQGT 323
            .||..:....:|.|:|:.:...::|::::.|.|:||.::.||..||..:.::..|..:|...:..
Zfish   259 SIAKLQENMKQNEAKVKELSAEIQELERRRDKEVGGVLRTLEETLSEAQRVDTKAQSALDLKKQN 323

  Fly   324 IQQDEKKIRMASKNIEDDERALAKKEADMAKVQGEFESLKEADARDSKAYEDAQKKLEAVSQGLS 388
            ::.:.||.:...||:|:|::.::.|||::||.....:::||...:|::|.|.||:..:|||.|||
Zfish   324 LKDETKKRKELVKNMEEDKKVMSAKEAEVAKAVERLKAVKEEGQKDAEALEAAQQHFKAVSAGLS 388

  Fly   389 TNENGEASTLQEQLIVAKEQFSEAQTTIKTSEIELRHTRGVLKQREGETQTNDAAYVKDKKLHDQ 453
            .||:|..:||..|::..|...|:|:|..|.::::|:|.:..||.::.:.:..|:.|.||:...:.
Zfish   389 ANEDGAEATLSGQMMTCKNDISKAETEAKQAQMKLKHAQQELKTKQAQVKKMDSGYKKDQDTFEA 453

  Fly   454 LVVEIKNLERQLQSLDYEGGHFEKLKQRRNDLHMRKRDLKRELDRCNASRYDL---------QYQ 509
            :...|:.|:.:::.|:||.|..|.|.:       :||...||:.:...:...|         :|.
Zfish   454 VNKCIEKLQAEMKKLNYEDGREECLLE-------QKRQFSREVIQLREAYESLMGQFPNLRFEYT 511

  Fly   510 DPEPNFDRRKVRGLVGKLFQVKDMQNSMALVQTAGGSLYSYVTDDDVTSKKILQRGNLQRRVTLI 574
            |||.|::|.||:|||..||.|.|:.|:.||...|||.||:.|.|::||.||:|::|.|:||.|:|
Zfish   512 DPERNWERSKVKGLVANLFTVTDVSNATALEVVAGGRLYNVVVDNEVTGKKLLEKGELRRRYTII 576

  Fly   575 PINKIQSGSLNRNVVEYAQNKVGAENVQWAMSLIDYDRYYEPVMKFCFGGTLICKDLIVAKQISY 639
            |:|||.:.:||.|||..|:..||.:||..|:||:.|:......|::.||.||:|..|..||::::
Zfish   577 PLNKISARTLNDNVVRTAKKLVGPDNVHTALSLVGYESELRKAMEYVFGTTLVCDSLDNAKKVAF 641

  Fly   640 DPRINCRSVTLEGDVVDPHGTVSGGAAPKGANVLEELHAIKQIEKEYREIDSEIAQVEKQIASIE 704
            |..::.::|||.|||.||.||::|||..:.|:||.:|..:|.|:...|..::|::.||.:::.::
Zfish   642 DKGVSTKTVTLGGDVFDPQGTLTGGARAQTASVLSKLAEVKDIQDSLRNKEAELSAVESELSGLK 706

  Fly   705 NQALAFNKMKENLDLRQHELTMCENRLAQTTFQQNQAEIEEMRERVKTLEQQIIDSREKQKTSQA 769
            ..|..:.::|:.|||:..|..:.|.:|.|::|.:.|.|:|.:|:.::..|..:..::|.||.::.
Zfish   707 GTAEKYRQLKQQLDLKTEEARILETKLQQSSFHKQQEELENLRKTIEECEDTLQKTKEVQKKAEE 771

  Fly   770 KIVDIEAKLADAKGYRERELNAATNEIKVTKQRAEKSRANWKKREQEFETLQLEITELQK----- 829
            |...:|.|:.:|...||:||.||..::...|.:|:......|:::||.:.:.||:.||::
Zfish   772 KYNVLENKMKNAAAEREKELKAAQQKLNQAKSKADAFSKRLKEKQQEADAVALELEELKREQAGY 836

  Fly   830 -----SIETAKKQHQEMIDNL-EKFKAELDALKVNSSSAASEVTELEQAIKEQKDKLRDQNKEMR 888
                 :::.|.|..||.|||: .:..|..:|::|           .::.:.:||:.:..|.:|::
Zfish   837 EQQIQAVDEALKAVQEQIDNMTTEVSANKEAVRV-----------AQEKLSQQKEVIMGQEREIK 890

  Fly   889 NQLVKKEKMLKENQEIELEVKKKENEQKKISSDAKEAKKRMEALEAKYPWIPEEKNCFGMKNTRY 953
            .:..:..::.::|.:.:|::|:.|:...|...|:.:|..::..:.|:..||..||:.||..||.|
Zfish   891 GKSGEANRLREQNNDAQLKIKELEHNISKHKKDSADATAKVARMLAENDWISSEKHLFGQPNTAY 955

  Fly   954 DYSKEDPHEAGNKLAKMQEKKDKMERTLNMNAIMVLDREEENFKETERRRNIVAMDKEKIKKIIV 1018
            |:...:|.|||.:|.:::|.|||:||.:|..|:.:|...||.:.:.::::.||..||.||.:.|.
Zfish   956 DFKTNNPKEAGQRLKRLEETKDKLERNVNRRAMNMLSEAEERYNDLKKKKRIVENDKAKILETIE 1020

  Fly  1019 KMDEEEQDQLNKAATEVNTNFSGIFSSLLPGAEAKLNPVHTNGCLTGLEIKVGFNGIWKESLGEL 1083
            ::|:::.:.||.|..:||.:|..|||:|||||.|:|.|....|.|.|||.||.....|||:|.||
Zfish  1021 ELDQKKNEALNVAWQKVNKDFGSIFSTLLPGANARLAPPEGCGVLDGLEFKVALGNTWKENLTEL 1085

  Fly  1084 SGGQKSLVALSLVLAMLKFSPAPLYILDEVDAALDMSHTQNIGSMLKQHFTNSQFLIVSLKDGLF 1148
            ||||:|||||||:||||.|.|||:|||||||||||:|||||||.||:.|||:|||::||||||:|
Zfish  1086 SGGQRSLVALSLILAMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFVVVSLKDGMF 1150

  Fly  1149 NHANVLFRTLFEEGVSTITR-------QVSRQATTNK 1178
            .:|||||:|.|.:|:||:||       :|..|.|..|
Zfish  1151 TNANVLFKTKFVDGISTVTRTAQTHEGKVLAQRTQEK 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMC2	NP_610995.1	Smc	1..1168	CDD:224117	498/1188 (42%)
		ABC_SMC2_euk	1..>170	CDD:213240	120/168 (71%)
		SMC_hinge	520..637	CDD:214944	56/116 (48%)
		V_Alix_like	690..933	CDD:187408	61/253 (24%)
		P-loop_NTPase	<1073..1167	CDD:304359	68/93 (73%)
smc2	NP_955836.2	Smc	1..1170	CDD:224117	498/1188 (42%)
		ABC_SMC2_euk	1..>156	CDD:213240	110/154 (71%)
		L_lactis_ph-MCP	252..>465	CDD:115336	61/212 (29%)
		SMC_hinge	522..639	CDD:214944	56/116 (48%)
		DUF4200	740..841	CDD:290574	27/100 (27%)
		P-loop_NTPase	<1074..1169	CDD:304359	68/94 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573351
Domainoid	1	1.000	947	1.000	Domainoid score	I36
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4705
Inparanoid	1	1.050	972	1.000	Inparanoid score	I300
OMA	1	1.010	-	-		QHG54206
OrthoDB	1	1.010	-	-		D119789at2759
OrthoFinder	1	1.000	-	-		FOG0003760
OrthoInspector	1	1.000	-	-		oto40768
orthoMCL	1	0.900	-	-		OOG6_101492
Panther	1	1.100	-	-	LDO	PTHR43941
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1352
SonicParanoid	1	1.000	-	-		X3124
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940